We are analyzing https://link.springer.com/article/10.1007/s00424-003-1117-9.

Title:
Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family | Pflügers Archiv - European Journal of Physiology
Description:
The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family resemble the classically-described System A and System N transport activities in terms of their functional properties and patterns of regulation. Transport of small, aliphatic amino acids by System A subtypes (SNAT1, SNAT2, and SNAT4) is rheogenic and pH sensitive. The System N subtypes SNAT3 and SNAT5 also countertransport H+, which may be key to their operation in reverse, and have narrower substrate profiles than do the System A subtypes. Glutamine emerges as a favored substrate throughout the family, except for SNAT4. The SLC38 transporters undoubtedly play many physiological roles including the transfer of glutamine from astrocyte to neuron in the CNS, ammonia detoxification and gluconeogenesis in the liver, and the renal response to acidosis. Probing their regulation has revealed additional roles, and recent work has considered SLC38 transporters as therapeutic targets in neoplasia.
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Keywords {🔍}

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Topics {✒️}

anti-1-amino-3-[18f]fluoromethyl-cyclobutane-1-carboxylic acid 2-amino-3-[18f]fluoro-2-methylpropanoic acid month download article/chapter ammonia detoxification 6-diazo-5-oxo-l-norleucine position-specific gap penalties related subjects phosphoinositide 3-kinase-dependent signalling pi3-kinase signaling code substrate-induced adaptive regulation +-coupled glutamine transporter intracellular sodium ions amino acid transport neutral amino acids nfat5 transcription factor distinct mediating systems amino acid transporter closely related analogs l-glutamine transport bidirectional glutamine transporter amino acid analogs amino acid deprivation amino acid analogues amino acid transporters full article pdf l-proline privacy choices/manage cookies amino acid metabolism glutamine cycle vesicular gaba transporter 3-[18f]fluoro-2-methyl-2 aminoisobutyric acid uptake investigators consulted support check access instant access [11c]methylaminoisobutyric acid o'regan mh l-type glutaminase aliphatic amino acids cationic amino acids radiolabeled amino acids skeletal-muscle cells cerebral alanine transport preferentially released glutamate high-affinity glutamate multiple kinase pathways skeletal muscle investigated classic transport activities blood efflux transport cultured neural cells

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         description:The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family resemble the classically-described System A and System N transport activities in terms of their functional properties and patterns of regulation. Transport of small, aliphatic amino acids by System A subtypes (SNAT1, SNAT2, and SNAT4) is rheogenic and pH sensitive. The System N subtypes SNAT3 and SNAT5 also countertransport H+, which may be key to their operation in reverse, and have narrower substrate profiles than do the System A subtypes. Glutamine emerges as a favored substrate throughout the family, except for SNAT4. The SLC38 transporters undoubtedly play many physiological roles including the transfer of glutamine from astrocyte to neuron in the CNS, ammonia detoxification and gluconeogenesis in the liver, and the renal response to acidosis. Probing their regulation has revealed additional roles, and recent work has considered SLC38 transporters as therapeutic targets in neoplasia.
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            Human Physiology
            Molecular Medicine
            Neurosciences
            Cell Biology
            Receptors
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      headline:Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family
      description:The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family resemble the classically-described System A and System N transport activities in terms of their functional properties and patterns of regulation. Transport of small, aliphatic amino acids by System A subtypes (SNAT1, SNAT2, and SNAT4) is rheogenic and pH sensitive. The System N subtypes SNAT3 and SNAT5 also countertransport H+, which may be key to their operation in reverse, and have narrower substrate profiles than do the System A subtypes. Glutamine emerges as a favored substrate throughout the family, except for SNAT4. The SLC38 transporters undoubtedly play many physiological roles including the transfer of glutamine from astrocyte to neuron in the CNS, ammonia detoxification and gluconeogenesis in the liver, and the renal response to acidosis. Probing their regulation has revealed additional roles, and recent work has considered SLC38 transporters as therapeutic targets in neoplasia.
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         Receptors
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