We are analyzing https://link.springer.com/article/10.1007/s004180050387.

Title:
Robert Feulgen Lecture 1998 | Histochemistry and Cell Biology
Description:
Attachment of leukocytes to the blood vessel wall initiates leukocyte extravasation. This enables leukocytes to migrate to and accumulate at sites of tissue injury or infection where they execute host-defense mechanisms. A series of vascular cell adhesion molecules on leukocytes and on endothelial cells mediate leukocyte attachment to the endothelium in a stepwise process. A large panel of about 40 known human chemokines is able to specifically activate certain leukocytes and attract them to migrate across the endothelial barrier and within tissue. The specific combination of molecular signals provided by the diversity of cytokines, adhesion molecules, and chemokines regulates the specificity and selectivity of the recruitment of certain subpopulations of leukocytes in vivo. This review will focus on selectins and chemokines which initiate the cell contact and regulate activation and chemoattraction of leukocytes.
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Keywords {🔍}

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Topics {✒️}

execute host-defense mechanisms month download article/chapter cell biology aims control leukocyte extravasation tissue injury cell biology adhesion molecules molecular signals provided privacy choices/manage cookies full article pdf cell contact related subjects european economic area von-esmarch-strasse 56 germany e-mail conditions privacy policy accepting optional cookies check access vivo perfusion system endothelial control instant access main content log endothelial barrier journal finder publish article ebnet article histochemistry article log privacy policy personal data books a tissue article cite optional cookies manage preferences data protection enables leukocytes leukocytes cross essential cookies cookies skip subscription content similar content information de tel institution subscribe journal publish usage analysis social media varying standards july 1999 volume 112 stepwise process

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         description:Attachment of leukocytes to the blood vessel wall initiates leukocyte extravasation. This enables leukocytes to migrate to and accumulate at sites of tissue injury or infection where they execute host-defense mechanisms. A series of vascular cell adhesion molecules on leukocytes and on endothelial cells mediate leukocyte attachment to the endothelium in a stepwise process. A large panel of about 40 known human chemokines is able to specifically activate certain leukocytes and attract them to migrate across the endothelial barrier and within tissue. The specific combination of molecular signals provided by the diversity of cytokines, adhesion molecules, and chemokines regulates the specificity and selectivity of the recruitment of certain subpopulations of leukocytes in vivo. This review will focus on selectins and chemokines which initiate the cell contact and regulate activation and chemoattraction of leukocytes.
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         Biochemistry
         Developmental Biology
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