We are analyzing https://link.springer.com/article/10.1007/s00418-014-1277-z.

Title:
Yip1B isoform is localized at ER–Golgi intermediate and cis-Golgi compartments and is not required for maintenance of the Golgi structure in skeletal muscle | Histochemistry and Cell Biology
Description:
The mechanism of endoplasmic reticulum (ER)–Golgi complex (GC) traffic is conserved from yeast to higher animals, but the architectures and the dynamics of vesicles’ traffic between ER and GC vary across cell types and species. Skeletal muscle is a unique tissue in which ER and GC undergo a structural reorganization during differentiation that completely remodels the secretory pathway. In mature skeletal muscle, the ER is turned into sarcoplasmic reticulum, which is composed of junctional and longitudinal regions specialized, respectively, in calcium release and uptake during contraction. During skeletal muscle differentiation, GC acquires a particular fragmented organization as it appears as spots both at the nuclear poles and along the fibers. The ubiquitary-expressed Yip1A isoform has been proposed to be involved in anterograde trafficking from the ER exit sites to the cis-side of the GC and in ER and GC architecture organization. We investigated the role of Yip1 in skeletal muscle. Here we report that, following skeletal muscle development, the expression of the Yip1A decreases and is replaced by the muscle-specific Yip1B isoform. Confocal microscope analysis revealed that in adult skeletal muscle the Yip1B isoform is localized in the ER–Golgi intermediate and cis-Golgi compartments. Finally, skeletal muscle knockdown experiments in vitro and in vivo suggested that Yip1B is not involved in GC structure maintenance.
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Keywords {🔍}

article, pubmed, google, scholar, cas, golgi, muscle, skeletal, cell, reticulum, complex, endoplasmic, biol, central, intermediate, access, protein, privacy, cookies, content, yipb, isoform, cisgolgi, structure, barone, sorrentino, sarcoplasmic, yipa, sites, ralston, information, publish, search, ergolgi, maintenance, september, mazzoli, vincenzo, involved, exit, membrane, apparatus, author, data, log, journal, research, localized, compartments, required,

Topics {✒️}

serena tronnolone & vincenzo sorrentino month download article/chapter pre-golgi intermediate compartment copi-independent retrograde transport endoplasmic reticulum-derived vesicles golgi membrane protein cis-golgi matrix proteins membrane protein enriched vincenzo sorrentino muscle-specific yip1b isoform related subjects ubiquitary-expressed yip1a isoform full article pdf mature skeletal muscle skeletal muscle development adult skeletal muscle privacy choices/manage cookies author information authors mammalian endoplasmic reticulum skeletal muscle differentiation skeletal muscle fibers endoplasmic reticulum structure dr jaakko saraste check access instant access cis-golgi compartments pre-golgi vacuoles er–golgi intermediate golgi complex reorganization cell biology aims transport gtpases ypt1p er exit sites article histochemistry sarcoplasmic reticulum skeletal muscle european economic area γ-sarcoglycan interactors fiber type-dependent microtubule organizing centers normal microtubule tracks telethon grant ggp13213 anti-p58 antibody article barone golgi apparatus remains conditions privacy policy yip1p–yif1p complex longitudinal regions specialized author correspondence article log endoplasmic reticulum

Questions {❓}

Zaal KJ, Reid E, Mousavi K, Zhang T, Mehta A, Bugnard E, Sartorelli V, Ralston E (2011) Who needs microtubules?

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         headline:Yip1B isoform is localized at ER–Golgi intermediate and cis-Golgi compartments and is not required for maintenance of the Golgi structure in skeletal muscle
         description:The mechanism of endoplasmic reticulum (ER)–Golgi complex (GC) traffic is conserved from yeast to higher animals, but the architectures and the dynamics of vesicles’ traffic between ER and GC vary across cell types and species. Skeletal muscle is a unique tissue in which ER and GC undergo a structural reorganization during differentiation that completely remodels the secretory pathway. In mature skeletal muscle, the ER is turned into sarcoplasmic reticulum, which is composed of junctional and longitudinal regions specialized, respectively, in calcium release and uptake during contraction. During skeletal muscle differentiation, GC acquires a particular fragmented organization as it appears as spots both at the nuclear poles and along the fibers. The ubiquitary-expressed Yip1A isoform has been proposed to be involved in anterograde trafficking from the ER exit sites to the cis-side of the GC and in ER and GC architecture organization. We investigated the role of Yip1 in skeletal muscle. Here we report that, following skeletal muscle development, the expression of the Yip1A decreases and is replaced by the muscle-specific Yip1B isoform. Confocal microscope analysis revealed that in adult skeletal muscle the Yip1B isoform is localized in the ER–Golgi intermediate and cis-Golgi compartments. Finally, skeletal muscle knockdown experiments in vitro and in vivo suggested that Yip1B is not involved in GC structure maintenance.
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            Sarcoplasmic reticulum
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      headline:Yip1B isoform is localized at ER–Golgi intermediate and cis-Golgi compartments and is not required for maintenance of the Golgi structure in skeletal muscle
      description:The mechanism of endoplasmic reticulum (ER)–Golgi complex (GC) traffic is conserved from yeast to higher animals, but the architectures and the dynamics of vesicles’ traffic between ER and GC vary across cell types and species. Skeletal muscle is a unique tissue in which ER and GC undergo a structural reorganization during differentiation that completely remodels the secretory pathway. In mature skeletal muscle, the ER is turned into sarcoplasmic reticulum, which is composed of junctional and longitudinal regions specialized, respectively, in calcium release and uptake during contraction. During skeletal muscle differentiation, GC acquires a particular fragmented organization as it appears as spots both at the nuclear poles and along the fibers. The ubiquitary-expressed Yip1A isoform has been proposed to be involved in anterograde trafficking from the ER exit sites to the cis-side of the GC and in ER and GC architecture organization. We investigated the role of Yip1 in skeletal muscle. Here we report that, following skeletal muscle development, the expression of the Yip1A decreases and is replaced by the muscle-specific Yip1B isoform. Confocal microscope analysis revealed that in adult skeletal muscle the Yip1B isoform is localized in the ER–Golgi intermediate and cis-Golgi compartments. Finally, skeletal muscle knockdown experiments in vitro and in vivo suggested that Yip1B is not involved in GC structure maintenance.
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      dateModified:2014-09-11T00:00:00Z
      pageStart:235
      pageEnd:243
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         Finger protein
         Yip
         Sarcoplasmic reticulum
         Skeletal muscle
         Golgi complex
         Biomedicine
         general
         Cell Biology
         Biochemistry
         Developmental Biology
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