We are analyzing https://link.springer.com/article/10.1007/s00418-003-0585-5.

Title:
Expression of stabilin-2, a novel fasciclin-like hyaluronan receptor protein, in murine sinusoidal endothelia, avascular tissues, and at solid/liquid interfaces | Histochemistry and Cell Biology
Description:
Stabilin-2, the hepatic hyaluronan receptor, has recently been cloned by us. Together with stabilin-1, stabilin-2 constitutes a novel family of fasciclin-like hyaluronan receptor homologues. Here, we analyzed expression of stabilin-2 (mStab-2) in a broad array of C57BL/6 mouse organs and tissues. While northern blot analysis showed positive expression of mStab-2 mRNA confined to liver and spleen, immunohistochemistry demonstrated mStab-2 protein expression in the endothelial sinuses of liver, lymph nodes, spleen, and bone marrow, and in specialized structures of eye, heart, brain, and kidney. Expression of mStab-2 was detected in corneal and lens epithelium, in mesenchymal cells of the heart valves, in the ependymal cells lining the ventricles in the brain, and in the prismatic epithelial cells covering the renal papillae. In pathological conditions, such as tumor growth or wound healing processes, mStab-2 was not expressed in the newly formed vasculature or other tissue components. Based on these results, we suggest that mStab-2 might be involved in the clearance of hyaluronan from the lymph or the blood circulation via the network of endothelial sinuses. At the other mStab-2-positive tissues sites that are either avascular and/or demarcate a solid/liquid interface, mStab-2 may serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan.
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Keywords {🔍}

google, scholar, pubmed, cas, hyaluronan, article, cells, laurent, endothelial, biol, fraser, cell, expression, stabilin, receptor, liver, mstab, kidney, tissue, access, morphogenesis, res, content, mouse, renal, development, human, smedsrød, hyaluronic, acid, biochem, privacy, cookies, protein, sinusoidal, tissues, schledzewski, goerdt, eye, rat, exp, pertoft, degradation, publish, search, fasciclinlike, hansen, lens, wound, circulation,

Topics {✒️}

ms-1 high-molecular-weight protein month download article/chapter berit hansen & sergij goerdt versican-rich pericellular matrix high-molecular-weight hyaluronan early-response gene signalling udp-glucose dehydrogenase required related subjects mstab-2-positive tissues sites solid/liquid interfaces full article pdf privacy choices/manage cookies hepatic hyaluronan receptor solid/liquid interface rat renomedullary interstitium lens epithelial cells sinusoidal endothelial cells wound healing processes dendritic cells/macrophages ureteric bud cells check access instant access murine sinusoidal endothelia cardiac valve formation ruprecht-karls-university liver endothelial cells article histochemistry c57bl/6 mouse organs ependymal cells lining cell biology aims epithelial-mesenchymal transition article falkowski hyaluronan receptor protein hyaluronan promotes lens vesicle morphogenesis european economic area newly formed vasculature distinct microvascular compartments primary biliary cirrhosis mechano-osmotic transducer mccourt pa theodor-kutzer-ufer 1-3 body autoradiographic study rejected human kidneys ductal branching morphogenesis renal water handling developing mouse heart maintain tissue integrity conditions privacy policy hyaluronan-mediated transformation

Questions {❓}

Petrides PE, Dittmann KH (1990) How do normal and leukemic white blood cells egress from the bone marrow?

Schema {🗺️}

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         description:Stabilin-2, the hepatic hyaluronan receptor, has recently been cloned by us. Together with stabilin-1, stabilin-2 constitutes a novel family of fasciclin-like hyaluronan receptor homologues. Here, we analyzed expression of stabilin-2 (mStab-2) in a broad array of C57BL/6 mouse organs and tissues. While northern blot analysis showed positive expression of mStab-2 mRNA confined to liver and spleen, immunohistochemistry demonstrated mStab-2 protein expression in the endothelial sinuses of liver, lymph nodes, spleen, and bone marrow, and in specialized structures of eye, heart, brain, and kidney. Expression of mStab-2 was detected in corneal and lens epithelium, in mesenchymal cells of the heart valves, in the ependymal cells lining the ventricles in the brain, and in the prismatic epithelial cells covering the renal papillae. In pathological conditions, such as tumor growth or wound healing processes, mStab-2 was not expressed in the newly formed vasculature or other tissue components. Based on these results, we suggest that mStab-2 might be involved in the clearance of hyaluronan from the lymph or the blood circulation via the network of endothelial sinuses. At the other mStab-2-positive tissues sites that are either avascular and/or demarcate a solid/liquid interface, mStab-2 may serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan.
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      description:Stabilin-2, the hepatic hyaluronan receptor, has recently been cloned by us. Together with stabilin-1, stabilin-2 constitutes a novel family of fasciclin-like hyaluronan receptor homologues. Here, we analyzed expression of stabilin-2 (mStab-2) in a broad array of C57BL/6 mouse organs and tissues. While northern blot analysis showed positive expression of mStab-2 mRNA confined to liver and spleen, immunohistochemistry demonstrated mStab-2 protein expression in the endothelial sinuses of liver, lymph nodes, spleen, and bone marrow, and in specialized structures of eye, heart, brain, and kidney. Expression of mStab-2 was detected in corneal and lens epithelium, in mesenchymal cells of the heart valves, in the ependymal cells lining the ventricles in the brain, and in the prismatic epithelial cells covering the renal papillae. In pathological conditions, such as tumor growth or wound healing processes, mStab-2 was not expressed in the newly formed vasculature or other tissue components. Based on these results, we suggest that mStab-2 might be involved in the clearance of hyaluronan from the lymph or the blood circulation via the network of endothelial sinuses. At the other mStab-2-positive tissues sites that are either avascular and/or demarcate a solid/liquid interface, mStab-2 may serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan.
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