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Title:
Two cases of benign neuromyelitis optica in patients with celiac disease | Journal of Neurology
Description:
Neuromyelitis optica (NMO) is an autoimmune inflammatory disorder of the central nervous system, which predominately affects optic nerves and spinal cord. Celiac disease (CD) or gluten sensitivity is an autoimmune enteropathy triggered by ingestion of wheat gliadin and related proteins in genetically susceptible individuals. Although NMO is associated with other autoimmune disorders in around 30% of cases, an association of NMO with CD has rarely been reported. We describe two Caucasian women who, nineteen and two years after diagnosis of CD, respectively, had recurrent episodes of myelitis and optic neuritis consistent with the diagnosis of NMO. Despite numerous relapses, NMO followed an unusually mild course with no persistent neurological deficit, indicating that recurrent NMO can follow a benign course with complete remission. We discuss in detail a possible link between NMO and pre-existing CD.
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article, google, scholar, pubmed, neuromyelitis, optica, disease, cas, neurology, jarius, nmo, celiac, bergamaschi, neurol, privacy, cookies, journal, research, gluten, content, data, information, publish, search, benign, autoimmune, sensitivity, neurological, access, log, cases, patients, august, robotti, optic, related, diagnosis, discover, multiple, sclerosis, antibodies, franciotta, download, author, springer, optional, personal, parties, european, policy,
Topics {✒️}
month download article/chapter optic neuritis consistent coeliac disease anti-gliadin antibodies bind multiple sclerosis celiac disease letter autoimmune inflammatory disorder autoimmune enteropathy triggered privacy choices/manage cookies gluten ataxia full article pdf central nervous system genetically susceptible individuals revised diagnostic criteria davies-jones ga immune cross-reactivity excellent technical assistance equally contributing authors celiac disease conditions privacy policy european economic area persistent neurological deficit accepting optional cookies scope submit manuscript journal finder publish autoimmune disorders author information authors pre-existing cd check access instant access article journal benign neuromyelitis optica article log article cite privacy policy related subjects neurology article personal data myelitis article bergamaschi books a disease pract neurol 8 optional cookies manage preferences wheat gliadin subscription content author correspondence gluten sensitivity journal publish
Questions {❓}
- Grossman G (2008) Neurological complications of coeliac disease: what is the evidence?
- Hadjivassiliou M, Gibson A, Davies-Jones GA et al (1996) Does cryptic gluten sensitivity play a part in neurological illness?
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headline:Two cases of benign neuromyelitis optica in patients with celiac disease
description:Neuromyelitis optica (NMO) is an autoimmune inflammatory disorder of the central nervous system, which predominately affects optic nerves and spinal cord. Celiac disease (CD) or gluten sensitivity is an autoimmune enteropathy triggered by ingestion of wheat gliadin and related proteins in genetically susceptible individuals. Although NMO is associated with other autoimmune disorders in around 30% of cases, an association of NMO with CD has rarely been reported. We describe two Caucasian women who, nineteen and two years after diagnosis of CD, respectively, had recurrent episodes of myelitis and optic neuritis consistent with the diagnosis of NMO. Despite numerous relapses, NMO followed an unusually mild course with no persistent neurological deficit, indicating that recurrent NMO can follow a benign course with complete remission. We discuss in detail a possible link between NMO and pre-existing CD.
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Mitoxantrone
Optic Neuritis
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headline:Two cases of benign neuromyelitis optica in patients with celiac disease
description:Neuromyelitis optica (NMO) is an autoimmune inflammatory disorder of the central nervous system, which predominately affects optic nerves and spinal cord. Celiac disease (CD) or gluten sensitivity is an autoimmune enteropathy triggered by ingestion of wheat gliadin and related proteins in genetically susceptible individuals. Although NMO is associated with other autoimmune disorders in around 30% of cases, an association of NMO with CD has rarely been reported. We describe two Caucasian women who, nineteen and two years after diagnosis of CD, respectively, had recurrent episodes of myelitis and optic neuritis consistent with the diagnosis of NMO. Despite numerous relapses, NMO followed an unusually mild course with no persistent neurological deficit, indicating that recurrent NMO can follow a benign course with complete remission. We discuss in detail a possible link between NMO and pre-existing CD.
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Mitoxantrone
Optic Neuritis
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Myelitis
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Neuroradiology
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