We are analyzing https://link.springer.com/article/10.1007/s00412-007-0113-9.

Title:
TFIIB and the regulation of transcription by RNA polymerase II | Chromosoma
Description:
Accurate transcription of a gene by RNA polymerase II requires the assembly of a group of general transcription factors at the promoter. The general transcription factor TFIIB plays a central role in preinitiation complex assembly, providing a bridge between promoter-bound TFIID and RNA polymerase II. TFIIB makes extensive contact with the core promoter via two independent DNA-recognition modules. In addition to interacting with other general transcription factors, TFIIB directly modulates the catalytic center of RNA polymerase II in the transcription complex. Moreover, TFIIB has been proposed as a target of transcriptional activator proteins that act to stimulate preinitiation complex assembly. In this review, we will discuss our current understanding of these activities of TFIIB.
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Keywords {🔍}

google, scholar, pubmed, cas, article, transcription, tfiib, rna, factor, polymerase, cell, biol, mol, promoter, human, roberts, complex, transcriptional, activation, domain, interaction, factors, core, protein, general, sci, iib, chem, proc, natl, acad, initiation, yeast, nature, gene, binding, sge, role, site, assembly, genes, dev, reinberg, dna, hampsey, roeder, preinitiation, green, chen, vivo,

Topics {✒️}

tfiib–tbp–tata–element ternary complex tata-binding protein–tfiib–dna complexes tata-binding protein-independent initiation site-specific protein–dna photocrosslinking human tfiid–iia–iib complex month download article/chapter independent dna-recognition modules core promoter elements d1/e1 core helices protein–protein cross-linking gene-specific transcription factor c-terminal core domain early transcriptional regulators tata-box binding protein tata box-binding protein probing zinc-binding effects promoter-specific transcription initiation blocks tfiib-rap30 binding sequence-specific dna binding vitamin d-mediated transcription tbp/tfb/promoter complex core promoter element tfg1/tfg2 dimer interface sequence-specific dna contacts activator-induced conformational change article chromosoma aims rna polymerase ii rna polymerase ii full article pdf pappas dl jr tata-binding protein tata binding protein conserved n-terminal region activator-mediated tfiib recruitment human gene encoding dna binding complex class ii promoter basal transcription factors acidic activating region rna polymerae ii transcription preinitiation complex contacts promoter dna general transcription factors privacy choices/manage cookies transcription activation domain start site selection article deng preinitiation complex assembly transcription start site n-terminal domain

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