We are analyzing https://link.springer.com/article/10.1007/s00404-014-3389-z.

Title:
Anti-tumour activity of phosphoinositide-3-kinase antagonist AEZS-126 in models of ovarian cancer | Archives of Gynecology and Obstetrics
Description:
Purpose Platinum resistance is the most crucial problem for treatment of ovarian cancer. There is a clinical need for new treatment strategies which overcome platinum resistance. Recently high level of AKT was shown to be involved in platinum resistance and furthermore in resistance against Natural-killer (NK)-cell mediated killing in ovarian cancer. Methods Here, we investigate the ability of the PI3K/AKT inhibitor AEZS-126 alone and in combination with rapamycin to selectively target ovarian cancer cell proliferation and survival in vitro by MTT-assays and FACS based analysis. Furthermore the mechanism of cytotoxicity is analysed by FACS based assays. The NK-killing efficiency of ovarian cancer cells with and without pre-treatment with AEZS-126 was analysed. Results AEZS-126 showed good anti-tumour activity in in vitro models of ovarian cancer. Main mechanism of cytotoxicity seems to be necroptosis which could be abrogated by co-incubation with necrostatin-1. Furthermore pre-treatment of platinum resistant cells with AEZS-126 resulted in an increased accessibility of these tumour cells for killing by NK-cells. Conclusion We demonstrated the highly efficient anti-tumour activity of AEZS-126 in in vitro models of ovarian cancer. Due to the good anti-tumour activity and the expected increase in NK-cell mediated killing even of platinum resistant tumour cells, AEZS-126 seems to be a promising candidate for clinical testing in ovarian cancer.
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article, pubmed, cancer, google, scholar, cas, ovarian, cell, breast, central, platinum, cells, aezs, immunol, res, human, hahne, resistance, access, clin, antitumour, activity, models, meyer, akt, carcinoma, natural, killer, privacy, cookies, content, data, vitro, tumor, mol, information, publish, search, gynecology, kurz, honig, treatment, methods, target, mechanism, resistant, open, chemotherapy, targeted, pathway,

Topics {✒️}

month download article/chapter good anti-tumour activity pi3k/pten/akt/mtor pathways targeted therapies potential therapeutic target human nk-cell receptors newly diagnosed african-american nk-cell mediated killing triple-negative breast cancer phosphoinositide-3-kinase antagonist aezs-126 ovarian tumours—current data single-institution compilation compared pi3k/akt inhibitor aezs-126 pi3k/akt/mtor pathway lanier ll anti-tumour activity mtor signaling pathways full article pdf platinum resistant cells nk cell proliferation resistant ovarian cancers ovarian cancer cells chain-related molecule overcome platinum resistance overcoming platinum resistance cell mediated killing human ovarian carcinoma privacy choices/manage cookies human ovarian cancers epithelial ovarian cancer natural killer cells nk cell recognition related subjects therapy—implications end results database triple-negative/basal human breast tumours adjunct chemotherapy treatment basal breast cancer akt/pkb pathway article archives nk-killing efficiency cancer drug discovery national cancer institute pi3k pathway alterations pi3k pathway play caspase-specific inhibitors breast carcinoma characteristics suppressing tumor development shaping tumor immunogenicity

Questions {❓}

Moulder SL (2010) Does the PI3K pathway play a role in basal breast cancer?
Vivier E, Raulet DH, Moretta A et al (2011) Innate or adaptive immunity?

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