We are analyzing https://link.springer.com/article/10.1007/s00403-015-1546-2.

Title:
The divergent roles of growth differentiation factor-15 (GDF-15) in benign and malignant skin pathologies | Archives of Dermatological Research
Description:
GDF-15 (Growth Differentiation Factor-15) is a member of the transforming growth factor β (TGF-β) superfamily. GDF-15 is not only involved in cancer development, progression, angiogenesis and metastasis, but also controls stress responses, bone formation, hematopoietic development, adipose tissue function and cardiovascular diseases. GDF-15, which is regulated by p53, has shown antitumorigenic and proapoptotic activities in vivo and in vitro. Also, GDF-15 is involved in skin biology and histamine-induced melanogenesis; it is overexpressed in melanoma cells and is associated with depth of tumor invasion and metastasis. GDF-15 level is increased in patients with systemic sclerosis and is related with the degree of skin sclerosis and intensity of pulmonary fibrosis. In the future, GDF-15 may be a potential target for therapy in benign disorders with skin fibrosis and malignant lesions of the skin.
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Keywords {🔍}

pubmed, google, scholar, article, cas, cancer, growth, res, melanoma, factor, cytokine, inhibitory, gdf, macrophage, lee, cells, cell, breit, kim, dermatol, biol, expression, differentiation, skin, tgfbeta, brown, transforming, fibrosis, central, malignant, development, bone, mic, human, clin, bauskin, research, superfamily, patients, systemic, sclerosis, gene, arch, privacy, cookies, content, member, access, lung, chem,

Topics {✒️}

growth/differentiation factor-15/macrophage-inhibiting cytokine-1 month download article/chapter anti-senescence factor tbx2 tgf-beta2 inhibits growth growth differentiation factor-15 tgf-beta1 polymorphism determines tgf-beta superfamily cytokine nested case-control study bleomycin-induced pulmonary fibrosis cellular signalling network tgf-beta superfamily member cumhur i̇brahim başsorgun growth inhibitory effect ayşe akman karakaş uv-induced skin damage macrophage inhibitory cytokine-1 macrophage inhibitory cytokine tgf-beta superfamily full article pdf histamine-induced melanogenesis uv-mediated regulation tgf-beta signaling tgf-beta pathway nsaid activated gene human dermal fibroblasts tyrosinase-related protein-1 privacy choices/manage cookies bone morphogenetic proteins paralkar vm systemic protumorigenic effects dermatology author correspondence transient gene transfer gene expression contribute bone morphogenic proteins dermatological research aims propeptide mediates formation systemic sclerosis normal human melanocytes central regulator mic-1 serum level retinoid-related molecules check access instant access fibroblast-derived gdf15 tgf-β cutaneous melanoma incidence baek sj glioblastoma cells independently article ünal

Questions {❓}

Sherr CJ, DePinho RA (2000) Cellular senescence: mitotic clock or culture shock?

Schema {🗺️}

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