We are analyzing https://link.springer.com/article/10.1007/s004010050726.

Title:
Low prevalence of apolipoprotein E ε4 allele in the neurofibrillary tangle predominant form of senile dementia | Acta Neuropathologica
Description:
Apolipoprotein E (apoE) genotypes were analyzed in a subset of demented very old patients who share a uniform neuropathological picture consisting of various numbers of neurofibrillary tangles (NFT) in allocortical areas of the inferomedial temporal lobe without significant numbers of either diffuse amyloid or neuritic plaques. Among 18 patients with this condition referred to as NFT-predominant senile dementia (average age at death 87 ± 4.7 years), we found allele frequencies of 0.11 ɛ2, 0.86 ɛ3 and 0.03 ɛ4, which are significantly different from allele frequencies reported in Alzheimer’s disease (0.04 ɛ2, 0.59 ɛ3 and 0.38 ɛ4). The low prevalence of the apoE ɛ4 allele in this subset of patients is striking and suggests that NFT-predominant senile dementia is a dementing neurodegenerative disease in which the deposition of Aβ-amyloid did not occur, possibly due to protective effects of ɛ2 and/or ɛ3 alleles or lack of a promoting effect of apoE ɛ4 on amyloidogenesis. We propose that NFT-predominant dementia is a variant of Alzheimer’s disease occurring in the very old.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

article, dementia, disease, access, alzheimers, privacy, cookies, content, allele, senile, neuropathology, information, publish, search, low, apolipoprotein, neurofibrillary, apoe, open, institute, data, log, journal, research, acta, prevalence, bancher, egensperger, kösel, patients, nftpredominant, discover, germany, springer, optional, personal, parties, policy, find, track, neuropathologica, tangle, predominant, form, cite, jellinger, graeber, explore, subset, neuropathological,

Topics {✒️}

month download article/chapter nft-predominant senile dementia related subjects dementing neurodegenerative disease full article pdf privacy choices/manage cookies nft-predominant dementia low prevalence european economic area scope submit manuscript inferomedial temporal lobe conditions privacy policy found allele frequencies allele frequencies reported accepting optional cookies hannover medical school check access instant access journal finder publish article log senile dementia acta neuropathol 94 article cite apoe ɛ4 allele article bancher neurofibrillary tangles privacy policy personal data disease occurring optional cookies manage preferences neuritic plaques a-1130 vienna books a subscription content similar content data protection diffuse amyloid aβ-amyloid essential cookies cookies skip ε4 allele institution subscribe journal publish usage analysis social media varying standards october 1997 volume 94 allocortical areas condition referred

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         headline:Low prevalence of apolipoprotein E ε4 allele in the neurofibrillary tangle predominant form of senile dementia
         description: Apolipoprotein E (apoE) genotypes were analyzed in a subset of demented very old patients who share a uniform neuropathological picture consisting of various numbers of neurofibrillary tangles (NFT) in allocortical areas of the inferomedial temporal lobe without significant numbers of either diffuse amyloid or neuritic plaques. Among 18 patients with this condition referred to as NFT-predominant senile dementia (average age at death 87 ± 4.7 years), we found allele frequencies of 0.11 ɛ2, 0.86 ɛ3 and 0.03 ɛ4, which are significantly different from allele frequencies reported in Alzheimer’s disease (0.04 ɛ2, 0.59 ɛ3 and 0.38 ɛ4). The low prevalence of the apoE ɛ4 allele in this subset of patients is striking and suggests that NFT-predominant senile dementia is a dementing neurodegenerative disease in which the deposition of Aβ-amyloid did not occur, possibly due to protective effects of ɛ2 and/or ɛ3 alleles or lack of a promoting effect of apoE ɛ4 on amyloidogenesis. We propose that NFT-predominant dementia is a variant of Alzheimer’s disease occurring in the very old.
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      headline:Low prevalence of apolipoprotein E ε4 allele in the neurofibrillary tangle predominant form of senile dementia
      description: Apolipoprotein E (apoE) genotypes were analyzed in a subset of demented very old patients who share a uniform neuropathological picture consisting of various numbers of neurofibrillary tangles (NFT) in allocortical areas of the inferomedial temporal lobe without significant numbers of either diffuse amyloid or neuritic plaques. Among 18 patients with this condition referred to as NFT-predominant senile dementia (average age at death 87 ± 4.7 years), we found allele frequencies of 0.11 ɛ2, 0.86 ɛ3 and 0.03 ɛ4, which are significantly different from allele frequencies reported in Alzheimer’s disease (0.04 ɛ2, 0.59 ɛ3 and 0.38 ɛ4). The low prevalence of the apoE ɛ4 allele in this subset of patients is striking and suggests that NFT-predominant senile dementia is a dementing neurodegenerative disease in which the deposition of Aβ-amyloid did not occur, possibly due to protective effects of ɛ2 and/or ɛ3 alleles or lack of a promoting effect of apoE ɛ4 on amyloidogenesis. We propose that NFT-predominant dementia is a variant of Alzheimer’s disease occurring in the very old.
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      dateModified:
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      pageEnd:409
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         tangle-predominant dementia
         Apolipoprotein E
         Amyloid
         Senile plaques
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