We are analyzing https://link.springer.com/article/10.1007/s00401-017-1746-2.

Title:
α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading | Acta Neuropathologica
Description:
Recent evidence suggests that disease progression in Parkinson’s disease (PD) could occur by the spreading of α-synuclein (α-syn) aggregates between neurons. Here we studied the role of astrocytes in the intercellular transfer and fate of α-syn fibrils, using in vitro and ex vivo models. α-Syn fibrils can be transferred to neighboring cells; however, the transfer efficiency changes depending on the cell types. We found that α-syn is efficiently transferred from astrocytes to astrocytes and from neurons to astrocytes, but less efficiently from astrocytes to neurons. Interestingly, α-syn puncta are mainly found inside the lysosomal compartments of the recipient cells. However, differently from neurons, astrocytes are able to efficiently degrade fibrillar α-syn, suggesting an active role for these cells in clearing α-syn deposits. Astrocytes co-cultured with organotypic brain slices are able to take up α-syn fibrils from the slices. Altogether our data support a role for astrocytes in trapping and clearing α-syn pathological deposits in PD.
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pubmed, article, google, scholar, cas, alphasynuclein, central, astrocytes, disease, neurons, cell, parkinsons, supplementary, material, pdf, αsyn, cells, bousset, aggregates, human, acta, αsynuclein, transfer, melki, fibrils, access, france, spreading, loria, lysosomal, transmission, neurosci, recherche, privacy, cookies, content, role, zurzolo, astrocyte, protein, plos, doijournalpone, nat, neurobiol, biol, lewy, lee, institut, fondation, data,

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month download article/chapter clearing α-syn deposits neuronal-glial cultures van der perren région ile-de-france marie skłodowska-curie fellowship extracellular alpha-synuclein species astrocyte-neuron metabolic cooperation jpnd-neutargets-anr-14-jpcd-0002-02 alpha-synuclein locus triplication neuron-specific protein localized extracellular alpha-synuclein aggregates alpha-synuclein lewy neurite alpha-synuclein amyloid aggregates vitro alpha-synuclein neurotoxicity alpha-synuclein immunoreactive astrocytes full article pdf endo-lysosomal system α-synuclein transfer di monte da ec joint programme fondation de france organotypic brain slices α-synuclein spread privacy choices/manage cookies α-syn fibrils α-syn puncta manning-bog ab alpha-synuclein spreading alpha-synuclein transfers institut de france article loria neuronal cell death rey nl robust rat model alpha-synuclein fibrils alpha-synuclein strains alpha-synuclein assembly alpha-synuclein propagates lee hj astrocyte activation fondation bettencourt-schueller human neuroblastoma cells chiara zurzolo alpha-synuclein aggregates disease suggest host lysosomal storage disorder france parkinson grant cultured human cells alpha-synuclein mice

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α-Synuclein and Glia in Parkinson’s Disease: A Beneficial or a Detrimental Duet for the Endo-Lysosomal System?

Schema {🗺️}

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