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We are analyzing https://link.springer.com/article/10.1007/s00401-015-1519-8.

Title:
Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets | Acta Neuropathologica
Description:
With the number of prognostic and predictive genetic markers in neuro-oncology steadily growing, the need for comprehensive molecular analysis of neuropathology samples has vastly increased. We therefore developed a customized enrichment/hybrid-capture-based next-generation sequencing (NGS) gene panel comprising the entire coding and selected intronic and promoter regions of 130 genes recurrently altered in brain tumors, allowing for the detection of single nucleotide variations, fusions, and copy number aberrations. Optimization of probe design, library generation and sequencing conditions on 150 samples resulted in a 5-workday routine workflow from the formalin-fixed paraffin-embedded sample to neuropathological report. This protocol was applied to 79 retrospective cases with established molecular aberrations for validation and 71 prospective cases for discovery of potential therapeutic targets. Concordance of NGS compared to established, single biomarker methods was 98.0 %, with discrepancies resulting from one case where a TERT promoter mutation was not called by NGS and three ATRX mutations not being detected by Sanger sequencing. Importantly, in samples with low tumor cell content, NGS was able to identify mutant alleles that were not detectable by traditional methods. Information derived from NGS data identified potential targets for experimental therapy in 37/47 (79 %) glioblastomas, 9/10 (90 %) pilocytic astrocytomas, and 5/14 (36 %) medulloblastomas in the prospective target discovery cohort. In conclusion, we present the settings for high-throughput, adaptive next-generation sequencing in routine neuropathology diagnostics. Such an approach will likely become highly valuable in the near future for treatment decision making, as more therapeutic targets emerge and genetic information enters the classification of brain tumors.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {๐Ÿ“š}

  • Education
  • Science
  • Health & Fitness

Content Management System {๐Ÿ“}

What CMS is link.springer.com built with?

Custom-built

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Traffic Estimate {๐Ÿ“ˆ}

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๐ŸŒ  Phenomenal Traffic: 5M - 10M visitors per month


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How Does Link.springer.com Make Money? {๐Ÿ’ธ}

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Keywords {๐Ÿ”}

article, pubmed, google, scholar, sequencing, cancer, cas, heidelberg, research, german, germany, center, nextgeneration, sahm, acta, capper, central, dkfz, analysis, brain, tumor, schrimpf, david, clinical, dna, jones, reuss, accessed, oct, neuropathol, content, data, information, routine, koelsche, neuropathology, access, pathol, idh, consortium, privacy, cookies, diagnostics, targets, kratz, christian, korshunov, wiestler, wick, witt,

Topics {โœ’๏ธ}

/content/dam/illumina-support/documents/documentation/software_documentation/bcl2fastq/bcl2fastq2-v216-software-guide-15051736 org/packages/release/bioc/html/conumee formalin-fixed paraffin-embedded sample formalin-fixed paraffin-embedded dna customized enrichment/hybrid-capture-based month download article/chapter andreas von deimling christel herold-mende accurate long-read alignment formalin-fixed tissues egfrviii-targeted vaccination therapy neuro-oncology steadily growing io/hts-specs/samv1 io/hts-specs/vcfv4 mutation-specific monoclonal antibody tumor rna-seq data neuropathology-haarlem consensus guidelines idh mutant diffuse copy number aberrations ruprecht-karls-university heidelberg identifies actionable targets high-throughput sequencing data routine neuropathology diagnostics melanie bewerunge-hudler von deimling de la orden clinical sequencing applications privacy choices/manage cookies full article pdf related subjects potential therapeutic targets andrey korshunov generation molecular genetics translational cancer research louis dn diffuse astrocytoma treatment decision making target capture experiments haplotype-based approaches identify mutant alleles 5-workday routine workflow reuss de therapeutic targets emerge german cancer aid pilocytic astrocytoma comprehensive molecular analysis combined molecular analysis melting curve analysis pediatric neurooncology dna sequencing genomics

Schema {๐Ÿ—บ๏ธ}

WebPage:
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         headline:Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets
         description:With the number of prognostic and predictive genetic markers in neuro-oncology steadily growing, the need for comprehensive molecular analysis of neuropathology samples has vastly increased. We therefore developed a customized enrichment/hybrid-capture-based next-generation sequencing (NGS) gene panel comprising the entire coding and selected intronic and promoter regions of 130 genes recurrently altered in brain tumors, allowing for the detection of single nucleotide variations, fusions, and copy number aberrations. Optimization of probe design, library generation and sequencing conditions on 150 samples resulted in a 5-workday routine workflow from the formalin-fixed paraffin-embedded sample to neuropathological report. This protocol was applied to 79 retrospective cases with established molecular aberrations for validation and 71 prospective cases for discovery of potential therapeutic targets. Concordance of NGS compared to established, single biomarker methods was 98.0ย %, with discrepancies resulting from one case where a TERT promoter mutation was not called by NGS and three ATRX mutations not being detected by Sanger sequencing. Importantly, in samples with low tumor cell content, NGS was able to identify mutant alleles that were not detectable by traditional methods. Information derived from NGS data identified potential targets for experimental therapy in 37/47 (79ย %) glioblastomas, 9/10 (90ย %) pilocytic astrocytomas, and 5/14 (36ย %) medulloblastomas in the prospective target discovery cohort. In conclusion, we present the settings for high-throughput, adaptive next-generation sequencing in routine neuropathology diagnostics. Such an approach will likely become highly valuable in the near future for treatment decision making, as more therapeutic targets emerge and genetic information enters the classification of brain tumors.
         datePublished:2015-12-15T00:00:00Z
         dateModified:2015-12-15T00:00:00Z
         pageStart:903
         pageEnd:910
         sameAs:https://doi.org/10.1007/s00401-015-1519-8
         keywords:
            Medulloblastoma
            Pilocytic Astrocytoma
            FFPE Tissue
            Copy Number Aberration
            Diffuse Glioma
            Pathology
            Neurosciences
         image:
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            name:Acta Neuropathologica
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               1432-0533
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ScholarlyArticle:
      headline:Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets
      description:With the number of prognostic and predictive genetic markers in neuro-oncology steadily growing, the need for comprehensive molecular analysis of neuropathology samples has vastly increased. We therefore developed a customized enrichment/hybrid-capture-based next-generation sequencing (NGS) gene panel comprising the entire coding and selected intronic and promoter regions of 130 genes recurrently altered in brain tumors, allowing for the detection of single nucleotide variations, fusions, and copy number aberrations. Optimization of probe design, library generation and sequencing conditions on 150 samples resulted in a 5-workday routine workflow from the formalin-fixed paraffin-embedded sample to neuropathological report. This protocol was applied to 79 retrospective cases with established molecular aberrations for validation and 71 prospective cases for discovery of potential therapeutic targets. Concordance of NGS compared to established, single biomarker methods was 98.0ย %, with discrepancies resulting from one case where a TERT promoter mutation was not called by NGS and three ATRX mutations not being detected by Sanger sequencing. Importantly, in samples with low tumor cell content, NGS was able to identify mutant alleles that were not detectable by traditional methods. Information derived from NGS data identified potential targets for experimental therapy in 37/47 (79ย %) glioblastomas, 9/10 (90ย %) pilocytic astrocytomas, and 5/14 (36ย %) medulloblastomas in the prospective target discovery cohort. In conclusion, we present the settings for high-throughput, adaptive next-generation sequencing in routine neuropathology diagnostics. Such an approach will likely become highly valuable in the near future for treatment decision making, as more therapeutic targets emerge and genetic information enters the classification of brain tumors.
      datePublished:2015-12-15T00:00:00Z
      dateModified:2015-12-15T00:00:00Z
      pageStart:903
      pageEnd:910
      sameAs:https://doi.org/10.1007/s00401-015-1519-8
      keywords:
         Medulloblastoma
         Pilocytic Astrocytoma
         FFPE Tissue
         Copy Number Aberration
         Diffuse Glioma
         Pathology
         Neurosciences
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00401-015-1519-8/MediaObjects/401_2015_1519_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00401-015-1519-8/MediaObjects/401_2015_1519_Fig2_HTML.gif
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         name:Acta Neuropathologica
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            1432-0533
            0001-6322
         volumeNumber:131
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
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            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
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      author:
            name:Felix Sahm
            affiliation:
                  name:Ruprecht-Karls-University Heidelberg
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniel Schrimpf
            affiliation:
                  name:Ruprecht-Karls-University Heidelberg
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David T. W. Jones
            affiliation:
                  name:German Cancer Research Center (DKFZ)
                  address:
                     name:Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
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            name:Jochen Meyer
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                  name:German Cancer Research Center (DKFZ)
                  address:
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            name:Ruprecht-Karls-University Heidelberg
            address:
               name:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Research Center (DKFZ)
            address:
               name:Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Andrey Korshunov
      affiliation:
            name:Ruprecht-Karls-University Heidelberg
            address:
               name:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Research Center (DKFZ)
            address:
               name:Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Benedikt Wiestler
      affiliation:
            name:Heidelberg University Hospital
            address:
               name:Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Research Center (DKFZ)
            address:
               name:Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Ivo Buchhalter
      affiliation:
            name:German Cancer Research Center (DKFZ)
            address:
               name:Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Research Center (DKFZ)
            address:
               name:Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Till Milde
      affiliation:
            name:Heidelberg University Hospital, and National Center for Tumor Diseases (NCT)
            address:
               name:Department of Pediatric Oncology, Haematology and Immunology, Heidelberg University Hospital, and National Center for Tumor Diseases (NCT), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Consortium for Translational Cancer Research (DKTK)
            address:
               name:Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Florian Selt
      affiliation:
            name:Heidelberg University Hospital, and National Center for Tumor Diseases (NCT)
            address:
               name:Department of Pediatric Oncology, Haematology and Immunology, Heidelberg University Hospital, and National Center for Tumor Diseases (NCT), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Consortium for Translational Cancer Research (DKTK)
            address:
               name:Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Dominik Sturm
      affiliation:
            name:German Cancer Research Center (DKFZ)
            address:
               name:Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Heidelberg University Hospital, and National Center for Tumor Diseases (NCT)
            address:
               name:Department of Pediatric Oncology, Haematology and Immunology, Heidelberg University Hospital, and National Center for Tumor Diseases (NCT), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Marcel Kool
      affiliation:
            name:German Cancer Research Center (DKFZ)
            address:
               name:Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Manuela Hummel
      affiliation:
            name:German Cancer Research Center (DKFZ)
            address:
               name:Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Melanie Bewerunge-Hudler
      affiliation:
            name:German Cancer Research Center (DKFZ)
            address:
               name:Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Christian Mawrin
      affiliation:
            name:Otto von Guericke University Magdeburg
            address:
               name:Department of Neuropathology, Otto von Guericke University Magdeburg, Magdeburg, Germany
               type:PostalAddress
            type:Organization
      name:Ulrich Schรผller
      affiliation:
            name:Ludwig-Maximilians-University
            address:
               name:Center of Neuropathology, Ludwig-Maximilians-University, Munich, Germany
               type:PostalAddress
            type:Organization
      name:Christine Jungk
      affiliation:
            name:Heidelberg University Hospital
            address:
               name:Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Antje Wick
      affiliation:
            name:Heidelberg University Hospital
            address:
               name:Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Research Center (DKFZ)
            address:
               name:Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Olaf Witt
      affiliation:
            name:Heidelberg University Hospital, and National Center for Tumor Diseases (NCT)
            address:
               name:Department of Pediatric Oncology, Haematology and Immunology, Heidelberg University Hospital, and National Center for Tumor Diseases (NCT), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Consortium for Translational Cancer Research (DKTK)
            address:
               name:Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Michael Platten
      affiliation:
            name:Heidelberg University Hospital
            address:
               name:Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Research Center (DKFZ)
            address:
               name:Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Christel Herold-Mende
      affiliation:
            name:Heidelberg University Hospital
            address:
               name:Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Andreas Unterberg
      affiliation:
            name:Heidelberg University Hospital
            address:
               name:Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Stefan M. Pfister
      affiliation:
            name:German Cancer Research Center (DKFZ)
            address:
               name:Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Heidelberg University Hospital, and National Center for Tumor Diseases (NCT)
            address:
               name:Department of Pediatric Oncology, Haematology and Immunology, Heidelberg University Hospital, and National Center for Tumor Diseases (NCT), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Wolfgang Wick
      affiliation:
            name:Heidelberg University Hospital
            address:
               name:Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Research Center (DKFZ)
            address:
               name:Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Andreas von Deimling
      affiliation:
            name:Ruprecht-Karls-University Heidelberg
            address:
               name:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Research Center (DKFZ)
            address:
               name:Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Pediatric Oncology, Haematology and Immunology, Heidelberg University Hospital, and National Center for Tumor Diseases (NCT), Heidelberg, Germany
      name:Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany
      name:Department of Pediatric Oncology, Haematology and Immunology, Heidelberg University Hospital, and National Center for Tumor Diseases (NCT), Heidelberg, Germany
      name:Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany
      name:Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Pediatric Oncology, Haematology and Immunology, Heidelberg University Hospital, and National Center for Tumor Diseases (NCT), Heidelberg, Germany
      name:Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Otto von Guericke University Magdeburg, Magdeburg, Germany
      name:Center of Neuropathology, Ludwig-Maximilians-University, Munich, Germany
      name:Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany
      name:Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Pediatric Oncology, Haematology and Immunology, Heidelberg University Hospital, and National Center for Tumor Diseases (NCT), Heidelberg, Germany
      name:Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany
      name:Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany
      name:Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany
      name:Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Pediatric Oncology, Haematology and Immunology, Heidelberg University Hospital, and National Center for Tumor Diseases (NCT), Heidelberg, Germany
      name:Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany
      name:Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
      name:Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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