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Title:
Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease | Acta Neuropathologica
Description:
Hippocampal sclerosis of aging (HS-Aging) is a causative factor in a large proportion of elderly dementia cases. The current definition of HS-Aging rests on pathologic criteria: neuronal loss and gliosis in the hippocampal formation that is out of proportion to AD-type pathology. HS-Aging is also strongly associated with TDP-43 pathology. HS-Aging pathology appears to be most prevalent in the oldest-old: autopsy series indicate that 5โ30 % of nonagenarians have HS-Aging pathology. Among prior studies, differences in study design have contributed to the study-to-study variability in reported disease prevalence. The presence of HS-Aging pathology correlates with significant cognitive impairment which is often misdiagnosed as AD clinically. The antemortem diagnosis is further confounded by other diseases linked to hippocampal atrophy including frontotemporal lobar degeneration and cerebrovascular pathologies. Recent advances characterizing the neurocognitive profile of HS-Aging patients have begun to provide clues that may help identify living individuals with HS-Aging pathology. Structural brain imaging studies of research subjects followed to autopsy reveal hippocampal atrophy that is substantially greater in people with eventual HS-Aging pathology, compared to those with AD pathology alone. Data are presented from individuals who were followed with neurocognitive and neuroradiologic measurements, followed by neuropathologic evaluation at the University of Kentucky. Finally, we discuss factors that are hypothesized to cause or modify the disease. We conclude that the published literature on HS-Aging provides strong evidence of an important and under-appreciated brain disease of aging. Unfortunately, there is no therapy or preventive strategy currently available.
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Keywords {๐}
google, scholar, pubmed, article, cas, disease, hippocampal, alzheimers, dementia, sclerosis, neuropathol, study, neurol, acta, van, aging, pathology, brain, tdp, alzheimer, nelson, neurology, dickson, smith, clinical, frontotemporal, dois, lee, elderly, cognitive, neuropathology, jicha, trojanowski, schmitt, degeneration, dis, weiner, abner, jellinger, hsaging, atrophy, lobar, neuropathologic, association, schneider, kryscio, bennett, white, davis, markesbery,
Topics {โ๏ธ}
month download article/chapter tar-dna binding protein-43 tdp43-mediated neurodegeneration proceedings/ieee international symposium genome-wide analysis reveals honolulu-asia aging study tdp-43 c-terminal fragments cerebrovascular diseaseโpractical issues cerebral white-matter hyperintensities brain-wide imaging phenotypes high-morbidity brain disease older japanese-american men late-life motor impairment amyotrophic lateral sclerosis hs-aging pathology appears eventual hs-aging pathology type-dependent oxidative damage post-encephalitic parkinsonism brains community-dwelling older persons full article pdf sanders-brown center hippocampal amyloid-beta tardbp mutations frontal lobe degeneration population-based clinicopathological study nature genetics 44 van deerlin vm privacy choices/manage cookies frontotemporal lobar degeneration postmortem mri study hs-aging pathology correlates thornton-wells ta community-based studies large autopsy cohort sanders-brown building 800 mri atrophy measures japanese-american men post-encephalitic parkinsonism epidemiological human studies common neurodegenerative pathologies van der lijn van der lugt van der zee calcineurin/nfat signaling inflammatory cytokines stimulate welsh-bohmer ka neurofibrillary tangle formation cerebrovascular pathology frontotemporal lobar dementia cerebral grey matter
Questions {โ}
- Imhof A, Kovari E, von Gunten A, Gold G, Rivara CB, Herrmann FR, Hof PR, Bouras C, Giannakopoulos P (2007) Morphological substrates of cognitive decline in nonagenarians and centenarians: A new paradigm?
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headline:Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease
description:Hippocampal sclerosis of aging (HS-Aging) is a causative factor in a large proportion of elderly dementia cases. The current definition of HS-Aging rests on pathologic criteria: neuronal loss and gliosis in the hippocampal formation that is out of proportion to AD-type pathology. HS-Aging is also strongly associated with TDP-43 pathology. HS-Aging pathology appears to be most prevalent in the oldest-old: autopsy series indicate that 5โ30ย % of nonagenarians have HS-Aging pathology. Among prior studies, differences in study design have contributed to the study-to-study variability in reported disease prevalence. The presence of HS-Aging pathology correlates with significant cognitive impairment which is often misdiagnosed as AD clinically. The antemortem diagnosis is further confounded by other diseases linked to hippocampal atrophy including frontotemporal lobar degeneration and cerebrovascular pathologies. Recent advances characterizing the neurocognitive profile of HS-Aging patients have begun to provide clues that may help identify living individuals with HS-Aging pathology. Structural brain imaging studies of research subjects followed to autopsy reveal hippocampal atrophy that is substantially greater in people with eventual HS-Aging pathology, compared to those with AD pathology alone. Data are presented from individuals who were followed with neurocognitive and neuroradiologic measurements, followed by neuropathologic evaluation at the University of Kentucky. Finally, we discuss factors that are hypothesized to cause or modify the disease. We conclude that the published literature on HS-Aging provides strong evidence of an important and under-appreciated brain disease of aging. Unfortunately, there is no therapy or preventive strategy currently available.
datePublished:2013-07-18T00:00:00Z
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headline:Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease
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name:Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
type:PostalAddress
type:Organization
name:University of Kentucky
address:
name:Department of Neurology, University of Kentucky, Lexington, USA
type:PostalAddress
type:Organization
PostalAddress:
name:Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
name:Division of Neuropathology, Department of Pathology, Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
name:Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
name:Department of Neurology, University of Kentucky, Lexington, USA
name:Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
name:Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
name:Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
name:Division of Neuropathology, Department of Pathology, Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
name:Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
name:Department of Biostatistics, University of Kentucky, Lexington, USA
name:Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
name:Department of Biostatistics, University of Kentucky, Lexington, USA
name:Department of Statistics, University of Kentucky, Lexington, USA
name:Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
name:Department of Anatomy and Neurobiology, University of Kentucky, Lexington, USA
name:Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
name:Department of Neurology, University of Kentucky, Lexington, USA
name:Institute of Clinical Neurobiology, Vienna, Austria
name:Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
name:Department of Anatomy and Neurobiology, University of Kentucky, Lexington, USA
name:Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA
name:Department of Neurology, University of Kentucky, Lexington, USA
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