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We are analyzing https://link.springer.com/article/10.1007/s00401-013-1148-z.

Title:
CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer’s disease | Acta Neuropathologica
Description:
Alzheimer’s disease (AD) and Lewy body diseases (LBD), e.g., Parkinson’s disease (PD) dementia and dementia with Lewy bodies (DLB), are common causes of geriatric cognitive impairments. In addition, AD and LBD are often found in the same patients at autopsy; therefore, biomarkers that can detect the presence of both pathologies in living subjects are needed. In this investigation, we report the assessment of α-synuclein (α-syn) in cerebrospinal fluid (CSF) and its association with CSF total tau (t-tau), phosphorylated tau181 (p-tau181), and amyloid beta1-42 (Aβ1-42) in subjects of the Alzheimer’s Disease Neuroimaging Initiative (ADNI; n = 389), with longitudinal clinical assessments. A strong correlation was noted between α-syn and t-tau in controls, as well as in patients with AD and mild cognitive impairment (MCI). However, the correlation is not specific to subjects in the ADNI cohort, as it was also seen in PD patients and controls enrolled in the Parkinson’s Progression Markers Initiative (PPMI; n = 102). A bimodal distribution of CSF α-syn levels was observed in the ADNI cohort, with high levels of α-syn in the subjects with abnormally increased t-tau values. Although a correlation was also noted between α-syn and p-tau181, there was a mismatch (α-syn–p-tau181-Mis), i.e., higher p-tau181 levels accompanied by lower α-syn levels in a subset of ADNI patients. We hypothesize that this α-syn–p-tau181-Mis is a CSF signature of concomitant LBD pathology in AD patients. Hence, we suggest that inclusion of measures of CSF α-syn and calculation of α-syn–p-tau181-Mis improves the diagnostic sensitivity/specificity of classic CSF AD biomarkers and better predicts longitudinal cognitive changes.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
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What CMS is link.springer.com built with?


Link.springer.com is powered by WORDPRESS.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,643,078 visitors per month in the current month.

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How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

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Keywords {🔍}

article, google, scholar, disease, alzheimers, pubmed, cas, trojanowski, alphasynuclein, neurol, csf, parkinsons, cerebrospinal, fluid, adni, shaw, tau, biomarkers, dementia, research, cognitive, neuropathol, acta, lewy, patients, subjects, initiative, alzheimer, data, clinical, pathology, αsynuclein, zhang, ppmi, vanderstichele, lee, montine, dois, toledo, body, αsyn, neurology, study, diseases, association, neuroimaging, progression, levels, access, disorders,

Topics {✒️}

α-syn–p-tau181-mis improves /wp-content/uploads/how_to_apply/adni_acknowledgement_list month download article/chapter α-syn–p-tau181-mis william maul measey-truman csf α-syn levels cerebrospinal fluid alpha-synuclein bristol-myers squibb company lower α-syn levels community-dwelling older persons total csf alpha-synuclein lewy body diseases open-source package α-synuclein levels predicts longitudinal cognitive lewy body variant lewy body pathology csf α-syn full article pdf org/projects/wrs/ zhang privacy choices/manage cookies lewy body disease lewy body disorders diagnostic sensitivity/specificity jack cr jr csf biomarker analyses soluble alpha-synuclein altered alpha-synuclein decreased alpha-synuclein alpha-synuclein concentration alpha-synuclein immunohistochemistry alpha-synuclein filaments van eldik lj human cerebrospinal fluid updated hypothetical model alpha-synuclein pathology jellinger ka takeda pharmaceutical company ucb pharma sa cerebrospinal fluid biomarkers neurodegenerative disease research de deyn pp cerebrospinal fluid measures cerebrospinal fluid aβ1-42 random-effects models industrial funding partners high levels de oliveira rm progression marker initiative article toledo

Schema {🗺️}

WebPage:
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         headline:CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer’s disease
         description:Alzheimer’s disease (AD) and Lewy body diseases (LBD), e.g., Parkinson’s disease (PD) dementia and dementia with Lewy bodies (DLB), are common causes of geriatric cognitive impairments. In addition, AD and LBD are often found in the same patients at autopsy; therefore, biomarkers that can detect the presence of both pathologies in living subjects are needed. In this investigation, we report the assessment of α-synuclein (α-syn) in cerebrospinal fluid (CSF) and its association with CSF total tau (t-tau), phosphorylated tau181 (p-tau181), and amyloid beta1-42 (Aβ1-42) in subjects of the Alzheimer’s Disease Neuroimaging Initiative (ADNI; n = 389), with longitudinal clinical assessments. A strong correlation was noted between α-syn and t-tau in controls, as well as in patients with AD and mild cognitive impairment (MCI). However, the correlation is not specific to subjects in the ADNI cohort, as it was also seen in PD patients and controls enrolled in the Parkinson’s Progression Markers Initiative (PPMI; n = 102). A bimodal distribution of CSF α-syn levels was observed in the ADNI cohort, with high levels of α-syn in the subjects with abnormally increased t-tau values. Although a correlation was also noted between α-syn and p-tau181, there was a mismatch (α-syn–p-tau181-Mis), i.e., higher p-tau181 levels accompanied by lower α-syn levels in a subset of ADNI patients. We hypothesize that this α-syn–p-tau181-Mis is a CSF signature of concomitant LBD pathology in AD patients. Hence, we suggest that inclusion of measures of CSF α-syn and calculation of α-syn–p-tau181-Mis improves the diagnostic sensitivity/specificity of classic CSF AD biomarkers and better predicts longitudinal cognitive changes.
         datePublished:2013-06-29T00:00:00Z
         dateModified:2013-06-29T00:00:00Z
         pageStart:683
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            Parkinson’s disease
            Dementia with Lewy body
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            Amyloid β
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            Pathology
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      headline:CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer’s disease
      description:Alzheimer’s disease (AD) and Lewy body diseases (LBD), e.g., Parkinson’s disease (PD) dementia and dementia with Lewy bodies (DLB), are common causes of geriatric cognitive impairments. In addition, AD and LBD are often found in the same patients at autopsy; therefore, biomarkers that can detect the presence of both pathologies in living subjects are needed. In this investigation, we report the assessment of α-synuclein (α-syn) in cerebrospinal fluid (CSF) and its association with CSF total tau (t-tau), phosphorylated tau181 (p-tau181), and amyloid beta1-42 (Aβ1-42) in subjects of the Alzheimer’s Disease Neuroimaging Initiative (ADNI; n = 389), with longitudinal clinical assessments. A strong correlation was noted between α-syn and t-tau in controls, as well as in patients with AD and mild cognitive impairment (MCI). However, the correlation is not specific to subjects in the ADNI cohort, as it was also seen in PD patients and controls enrolled in the Parkinson’s Progression Markers Initiative (PPMI; n = 102). A bimodal distribution of CSF α-syn levels was observed in the ADNI cohort, with high levels of α-syn in the subjects with abnormally increased t-tau values. Although a correlation was also noted between α-syn and p-tau181, there was a mismatch (α-syn–p-tau181-Mis), i.e., higher p-tau181 levels accompanied by lower α-syn levels in a subset of ADNI patients. We hypothesize that this α-syn–p-tau181-Mis is a CSF signature of concomitant LBD pathology in AD patients. Hence, we suggest that inclusion of measures of CSF α-syn and calculation of α-syn–p-tau181-Mis improves the diagnostic sensitivity/specificity of classic CSF AD biomarkers and better predicts longitudinal cognitive changes.
      datePublished:2013-06-29T00:00:00Z
      dateModified:2013-06-29T00:00:00Z
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         Alzheimer’s disease
         Parkinson’s disease
         Dementia with Lewy body
         Cerebrospinal fluid
         Amyloid β
         Tau
         α-Synuclein
         Pathology
         Neurosciences
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            address:
               name:Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, USA
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            name:University of Pennsylvania School of Medicine
            address:
               name:Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, USA
               type:PostalAddress
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      name:Jing Zhang
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            name:University of Washington School of Medicine
            address:
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