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Title:
What do we know about IDH1/2 mutations so far, and how do we use it? | Acta Neuropathologica
Description:
Whole genome analyses have facilitated the discovery of clinically relevant genetic alterations in a variety of diseases, most notably cancer. A prominent example of this was the discovery of mutations in isocitrate dehydrogenases 1 and 2 (IDH1/2) in a sizeable proportion of gliomas and some other neoplasms. Herein the normal functions of these enzymes, how the mutations alter their catalytic properties, the effects of their d-2-hydroxyglutarate metabolite, technical considerations in diagnostic neuropathology, implications about prognosis and therapeutic considerations, and practical applications and controversies regarding IDH1/2 mutation testing are discussed.
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google, scholar, pubmed, cas, idh, mutations, gliomas, mutation, cancer, isocitrate, glioma, dehydrogenase, neuropathol, acta, oncol, molecular, patients, brain, prognostic, pathol, hydroxyglutarate, leukemia, glioblastoma, res, survival, diffuse, cell, grade, astrocytomas, tumors, analysis, detection, med, cells, clin, article, tumor, nature, park, horbinski, acute, lee, myeloid, neurooncol, kim, study, hartmann, status, lowgrade, neuro,

Topics {✒️}

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Questions {❓}

DeGregori J (2011) Evolved tumor suppression: why are we so good at not getting cancer?
Duran M, Kamerling JP, Bakker HD, van Gennip AH, Wadman SK (1980) l-2-Hydroxyglutaric aciduria: an inborn error of metabolism?
What do we know about IDH1/2 mutations so far, and how do we use it?
What do we know about IDH1/2 mutations so far, and how do we use it?

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