We are analyzing https://link.springer.com/article/10.1007/s00401-008-0345-7.

Title:
Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease | Acta Neuropathologica
Description:
Lewy bodies, the histologic hallmark of Parkinson’s disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The distribution of Lewy bodies in iLBD is similar to the distribution in PD, but neuronal populations vulnerable to Lewy bodies do not show significant neuronal loss in iLBD. It remains unknown if Lewy bodies in this setting represent pre-symptomatic PD or an age-related change unrelated to PD. To address this question we identified cases of iLBD and used a marker for dopaminergic and noradrenergic neurons, tyrosine hydroxylase (TH), to determine if there were changes similar to those found in PD. TH immunoreactivity in the striatum and the epicardial nerve fibers was decreased in iLBD compared to normal controls, but not to the same extent as in PD. The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology.
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disease, google, scholar, pubmed, article, cas, parkinsons, lewy, neurol, neuropathol, body, dickson, bodies, pathology, acta, incidental, sympathetic, neurology, brain, takahashi, ilbd, exp, braak, idiopathic, privacy, cookies, content, delledonne, parisi, ahlskog, normal, cases, tyrosine, hydroxylase, access, neuropathology, alphasynuclein, autonomic, system, sleep, disorder, dopamine, cardiac, neurosurg, psychiatry, study, wakabayashi, mayo, usa, publish,

Topics {✒️}

month download article/chapter dopamine transporter fp-cit-spect lewy body-related alpha-synucleinopathy [123i]fp-cit spect [123i]fp-cit spet myocardial 123i-mibg uptake [11c]rti-32 pet studies i-metaiodobenzylguanidine myocardial scintigraphy early dopa-naive parkinson age-related change unrelated full article pdf disease-related brain pathology privacy choices/manage cookies incidental lewy bodies autonomic nervous system sympathetic tyrosine hydroxylase alpha-synucleinopathy demonstrated neuronal populations vulnerable sympathetic nervous system tyrosine hydroxylase expression decreased cardiac uptake lewy body disease epicardial nerve fibers alpha-synuclein pathology brain pathology related bowel movement frequency nigrostriatal dopamine system european economic area related subjects de vos ra jansen steur en dorsal horn layer mrc cfas cohort nih p50-ns40256-09 monica casey-castanedes conditions privacy policy author information authors alpha-synuclein lesions decreased striatal expression community-based studies pre-symptomatic parkinson clinically normal people clinico-pathological study baltimore longitudinal study cognitively normal elderly dalsing-hernandez je aged human brain accepting optional cookies bmc neurol 6 joshua menke

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Del Tredici K, Rub U, De Vos RA, Bohl JR, Braak H (2002) Where does Parkinson disease pathology begin in the brain?

Schema {🗺️}

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         headline:Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease
         description:Lewy bodies, the histologic hallmark of Parkinson’s disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The distribution of Lewy bodies in iLBD is similar to the distribution in PD, but neuronal populations vulnerable to Lewy bodies do not show significant neuronal loss in iLBD. It remains unknown if Lewy bodies in this setting represent pre-symptomatic PD or an age-related change unrelated to PD. To address this question we identified cases of iLBD and used a marker for dopaminergic and noradrenergic neurons, tyrosine hydroxylase (TH), to determine if there were changes similar to those found in PD. TH immunoreactivity in the striatum and the epicardial nerve fibers was decreased in iLBD compared to normal controls, but not to the same extent as in PD. The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology.
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            Heart
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      headline:Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease
      description:Lewy bodies, the histologic hallmark of Parkinson’s disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The distribution of Lewy bodies in iLBD is similar to the distribution in PD, but neuronal populations vulnerable to Lewy bodies do not show significant neuronal loss in iLBD. It remains unknown if Lewy bodies in this setting represent pre-symptomatic PD or an age-related change unrelated to PD. To address this question we identified cases of iLBD and used a marker for dopaminergic and noradrenergic neurons, tyrosine hydroxylase (TH), to determine if there were changes similar to those found in PD. TH immunoreactivity in the striatum and the epicardial nerve fibers was decreased in iLBD compared to normal controls, but not to the same extent as in PD. The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology.
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         Striatum
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