We are analyzing https://link.springer.com/article/10.1007/s00401-007-0285-7.

Title:
TDP-43-immunoreactive neuronal and glial inclusions in the neostriatum in amyotrophic lateral sclerosis with and without dementia | Acta Neuropathologica
Description:
TDP-43 is a major component of ubiquitin-positive, tau-negative inclusions in amyotrophic lateral sclerosis (ALS), and frontotemporal lobar degeneration. We immunohistochemically examined the neostriatum from 14 cases of classic ALS (cALS), six cases of ALS with dementia (ALS-D), and 20 control subjects. TDP-43-positive, crescent or circular inclusions were found in neostriatal small neurons in 19 of 20 cases of ALS, but not in controls. Two types of inclusions were found in the large neurons: ubiquitin-positive, TDP-43-negative rod-like inclusions, and ubiquitin- and TDP-43-positive pleomorphic inclusions. The latter were specific to ALS; they were found in seven cases of cALS and in all of ALS-D. TDP-43-positive glial inclusions were also found in 12 cases of cALS and in all of ALS-D. These TDP-43-positive neuronal and glial inclusions were more numerous in ALS-D than cALS. In ALS-D, neuronal loss in the substantia nigra was found in all the cases, whereas mild gliosis without obvious neuronal loss was noted in the neostriaum in only two cases. These findings suggest that the neostriatum is also involved in the disease process of ALS with and without dementia.
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Keywords {🔍}

article, google, scholar, pubmed, sclerosis, lateral, cas, amyotrophic, inclusions, dementia, disease, neuropathol, tdp, frontotemporal, motor, neuron, neurol, acta, lobar, degeneration, brain, neuronal, neostriatum, research, cases, mackenzie, ubiquitinpositive, patients, neuropathology, intraneuronal, ubiquitinated, mori, takahashi, ubiquitin, access, pathology, exp, neumann, trojanowski, privacy, cookies, content, kakita, wakabayashi, alsd, tdppositive, found, sporadic, familial, kretzschmar,

Topics {✒️}

month download article/chapter ubiquitin-positive tau-negative inclusions tar dna-binding protein neocortical ubiquitin-immunoreactive inclusions ubiquitin-immunoreactive intraneuronal inclusions tdp-43-positive pleomorphic inclusions motor cortex chun-feng tan ubiquitin-positive intraneuronal inclusions motor neuron disease neurodegenerative diseases amyotrophic lateral sclerosis full article pdf tdp-43-positive glial inclusions tdp-43-immunoreactive neuronal motor neurone disease motor neuron disorders frontotemporal lobar degeneration aging-related structures privacy choices/manage cookies neurodegenerative disease tau-negative inclusions disease intranuclear inclusions related subjects ubiquitin-immunoreactive skein tdp-43-positive neuronal neuronal intranuclear inclusions ubiquitinated neuronal inclusions white cl iii extra-motor cortices ubiquitin-positive inclusions ubiquitinated pathological lesions tdp-43-negative rod ubiquitinated intraneuronal inclusions josephs ka obvious neuronal loss article zhang neurology research group european economic area check access graff-radford nr amador-ortiz anti-actin antiserum temporal lobe lesions progressive supranuclear palsy van doorn pa piao ys anderson ver karoji memorial fund bioresource-based researches

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         description:TDP-43 is a major component of ubiquitin-positive, tau-negative inclusions in amyotrophic lateral sclerosis (ALS), and frontotemporal lobar degeneration. We immunohistochemically examined the neostriatum from 14 cases of classic ALS (cALS), six cases of ALS with dementia (ALS-D), and 20 control subjects. TDP-43-positive, crescent or circular inclusions were found in neostriatal small neurons in 19 of 20 cases of ALS, but not in controls. Two types of inclusions were found in the large neurons: ubiquitin-positive, TDP-43-negative rod-like inclusions, and ubiquitin- and TDP-43-positive pleomorphic inclusions. The latter were specific to ALS; they were found in seven cases of cALS and in all of ALS-D. TDP-43-positive glial inclusions were also found in 12 cases of cALS and in all of ALS-D. These TDP-43-positive neuronal and glial inclusions were more numerous in ALS-D than cALS. In ALS-D, neuronal loss in the substantia nigra was found in all the cases, whereas mild gliosis without obvious neuronal loss was noted in the neostriaum in only two cases. These findings suggest that the neostriatum is also involved in the disease process of ALS with and without dementia.
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      description:TDP-43 is a major component of ubiquitin-positive, tau-negative inclusions in amyotrophic lateral sclerosis (ALS), and frontotemporal lobar degeneration. We immunohistochemically examined the neostriatum from 14 cases of classic ALS (cALS), six cases of ALS with dementia (ALS-D), and 20 control subjects. TDP-43-positive, crescent or circular inclusions were found in neostriatal small neurons in 19 of 20 cases of ALS, but not in controls. Two types of inclusions were found in the large neurons: ubiquitin-positive, TDP-43-negative rod-like inclusions, and ubiquitin- and TDP-43-positive pleomorphic inclusions. The latter were specific to ALS; they were found in seven cases of cALS and in all of ALS-D. TDP-43-positive glial inclusions were also found in 12 cases of cALS and in all of ALS-D. These TDP-43-positive neuronal and glial inclusions were more numerous in ALS-D than cALS. In ALS-D, neuronal loss in the substantia nigra was found in all the cases, whereas mild gliosis without obvious neuronal loss was noted in the neostriaum in only two cases. These findings suggest that the neostriatum is also involved in the disease process of ALS with and without dementia.
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