We are analyzing https://link.springer.com/article/10.1007/s00401-006-0064-x.

Title:
Stratification of medulloblastoma on the basis of histopathological grading | Acta Neuropathologica
Description:
Medulloblastoma (WHO grade IV) is an embryonal tumour of the cerebellum and the most common malignant central nervous system tumour in children. Despite significant advances in treatment, 5-year survival rates are still less than 70%, suggesting the presence of subgroups with different response to radio/chemotherapy. In the present study, we re-evaluated a series of 347 medulloblastomas from the SIOP II clinical trial of the International Society of Paediatric Oncology to identify features predictive of clinical outcome. Relapse free survival for medulloblastomas with severe anaplasia [5-year rate: S(60)=49.5%], was significantly shorter than for tumours with moderate or mild anaplasia S(60)=65.4%; P=0.001). The difference between both groups was even larger when the presence or absence of extensive apoptosis was included (46.5 vs. 66.7%; P=0.0216). Other histological features including nodularity, necrosis, vascular proliferation and the presence of β-catenin mutations (7% of cases) were not predictive for relapse free survival. These findings indicate that degree of anaplasia is the most significant histologic feature predictive of the survival of medulloblastoma patients.
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Keywords {🔍}

google, scholar, article, pubmed, cas, medulloblastoma, medulloblastomas, cancer, clinical, kleihues, survival, study, mutations, giangaspero, oncology, anaplasia, group, neuropathol, neurol, prognostic, privacy, cookies, content, histopathological, ohgaki, system, paediatric, patients, oncol, burger, pediatric, exp, pathology, analysis, data, publish, research, search, acta, stratification, grading, wellek, masuoka, tumour, tumours, access, chapter, childhood, res, eberhart,

Topics {✒️}

month download article/chapter embryonal tumour �large cell/anaplastic” medulloblastomas relapse free survival beta-catenin status predicts average-risk pediatric medulloblastomas oncogenic b-catenin mutations clinical disease spectrum β-catenin mutations wnt/wingless pathway related subjects full article pdf large-cell medulloblastomas 5-year survival rates privacy choices/manage cookies apoptotic cell death postoperative clinical state spanish paediatric medulloblastomas b-catenin gene beta-catenin signaling rome la sapienza article giangaspero molecular cytogenetic stratification clinico-pathologic study prospective randomised trial hiroko ohgaki highly aggressive behavior european economic area lady justice casting human hepatocellular carcinomas mahler-araujo bm laws er jr failure time date primitive neuroectodermal tumors cross-classified data conditions privacy policy identify features predictive cancer res 61 cancer res 58 accepting optional cookies paediatric oncology mcmanamy cs ellison dw lamont jm brain wnt signalling c-myc expression maire jp adult cerebellar medulloblastomas united kingdom children

Questions {❓}

Ellison DW, Clifford SC, Gajjar A, Gilbertson RJ (2003) What’s new in neuro-oncology?
Perry A (2002) Medulloblastomas with favorable versus unfavorable histology: how many small blue cell tumor types are there in the brain?

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         description:Medulloblastoma (WHO grade IV) is an embryonal tumour of the cerebellum and the most common malignant central nervous system tumour in children. Despite significant advances in treatment, 5-year survival rates are still less than 70%, suggesting the presence of subgroups with different response to radio/chemotherapy. In the present study, we re-evaluated a series of 347 medulloblastomas from the SIOP II clinical trial of the International Society of Paediatric Oncology to identify features predictive of clinical outcome. Relapse free survival for medulloblastomas with severe anaplasia [5-year rate: S(60)=49.5%], was significantly shorter than for tumours with moderate or mild anaplasia S(60)=65.4%; P=0.001). The difference between both groups was even larger when the presence or absence of extensive apoptosis was included (46.5 vs. 66.7%; P=0.0216). Other histological features including nodularity, necrosis, vascular proliferation and the presence of β-catenin mutations (7% of cases) were not predictive for relapse free survival. These findings indicate that degree of anaplasia is the most significant histologic feature predictive of the survival of medulloblastoma patients.
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