We are analyzing https://link.springer.com/article/10.1007/s003950200000.

Title:
Pleiotropic effects of HMG-CoA reductase inhibitors | Basic Research in Cardiology
Description:
HMG CoA reductase inhibitiors (statins) have been shown to be effective lipid lowering agents and are able to significantly reduce cardiovascular mortality and morbidity in patients at risk for cardiovascular disease. Recent clinical and experimental data suggest that the benefit of statins may extend beyond their hepatic effects on serum cholesterol levels. This review summarizes the current evidence and the molecular mechanisms of the direct effects of statins on plaque stability, inflammation, endothelial function, oxidative stress, thrombosis and stroke. Furthermore, recent data on the effects of statins on bone marrow, bone density and dementia are described. In summary, statins have emerged as a novel and powerful tool to study cardiovascular biology, including protein isoprenylation, small G protein function, leukocyte activity and endothelial progenitor cells. These pleiotropic properties of statins may have important clinical implications in addition to lowering serum cholesterol.
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Keywords {🔍}

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Topics {✒️}

hmg-coa reductase inhibitors month download article/chapter article basic research privacy choices/manage cookies pleiotropic effects full article pdf lowering serum cholesterol european economic area serum cholesterol levels review summarizes study cardiovascular biology including protein isoprenylation innere medizin iii universitätskliniken des saarlandes conditions privacy policy experimental data suggest endothelial progenitor cells important clinical implications accepting optional cookies related subjects check access instant access pleiotropic properties journal finder publish article werner hepatic effects direct effects privacy policy article log personal data books a optional cookies manage preferences cardiology aims cardiovascular disease nickenig article cite subscription content similar content effects essential cookies data protection cookies skip recent data recent clinical institution subscribe journal publish laufs endothelial function protein function

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         headline:Pleiotropic effects of HMG-CoA reductase inhibitors
         description: HMG CoA reductase inhibitiors (statins) have been shown to be effective lipid lowering agents and are able to significantly reduce cardiovascular mortality and morbidity in patients at risk for cardiovascular disease. Recent clinical and experimental data suggest that the benefit of statins may extend beyond their hepatic effects on serum cholesterol levels. This review summarizes the current evidence and the molecular mechanisms of the direct effects of statins on plaque stability, inflammation, endothelial function, oxidative stress, thrombosis and stroke. Furthermore, recent data on the effects of statins on bone marrow, bone density and dementia are described. In summary, statins have emerged as a novel and powerful tool to study cardiovascular biology, including protein isoprenylation, small G protein function, leukocyte activity and endothelial progenitor cells. These pleiotropic properties of statins may have important clinical implications in addition to lowering serum cholesterol.
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      headline:Pleiotropic effects of HMG-CoA reductase inhibitors
      description: HMG CoA reductase inhibitiors (statins) have been shown to be effective lipid lowering agents and are able to significantly reduce cardiovascular mortality and morbidity in patients at risk for cardiovascular disease. Recent clinical and experimental data suggest that the benefit of statins may extend beyond their hepatic effects on serum cholesterol levels. This review summarizes the current evidence and the molecular mechanisms of the direct effects of statins on plaque stability, inflammation, endothelial function, oxidative stress, thrombosis and stroke. Furthermore, recent data on the effects of statins on bone marrow, bone density and dementia are described. In summary, statins have emerged as a novel and powerful tool to study cardiovascular biology, including protein isoprenylation, small G protein function, leukocyte activity and endothelial progenitor cells. These pleiotropic properties of statins may have important clinical implications in addition to lowering serum cholesterol.
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