We are analyzing https://link.springer.com/article/10.1007/s00395-020-0782-6.

Title:
Action of iron chelator on intramyocardial hemorrhage and cardiac remodeling following acute myocardial infarction | Basic Research in Cardiology
Description:
Intramyocardial hemorrhage is an independent predictor of adverse outcomes in ST-segment elevation myocardial infarction (STEMI). Iron deposition resulting from ischemia–reperfusion injury (I/R) is pro-inflammatory and has been associated with adverse remodeling. The role of iron chelation in hemorrhagic acute myocardial infarction (AMI) has never been explored. The purpose of this study was to investigate the cardioprotection offered by the iron-chelating agent deferiprone (DFP) in a porcine AMI model by evaluating hemorrhage neutralization and subsequent cardiac remodeling. Two groups of animals underwent a reperfused AMI procedure: control and DFP treated (N = 7 each). A comprehensive MRI examination was performed in healthy state and up to week 4 post-AMI, followed by histological assessment. Infarct size was not significantly different between the two groups; however, the DFP group demonstrated earlier resolution of hemorrhage (by T2* imaging) and edema (by T2 imaging). Additionally, ventricular enlargement and myocardial hypertrophy (wall thickness and mass) were significantly smaller with DFP, suggesting reduced adverse remodeling, compared to control. The histologic results were consistent with the MRI findings. To date, there is no effective targeted therapy for reperfusion hemorrhage. Our proof-of-concept study is the first to identify hemorrhage-derived iron as a therapeutic target in I/R and exploit the cardioprotective properties of an iron-chelating drug candidate in the setting of AMI. Iron chelation could potentially serve as an adjunctive therapy in hemorrhagic AMI.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Non-Profit & Charity

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

pubmed, article, google, scholar, myocardial, cas, infarction, central, iron, imaging, acute, hemorrhage, cardiovasc, heart, injury, ghugre, reperfusion, magnetic, coronary, circulation, resonance, microvascular, remodeling, circ, cardiac, wood, infarct, obstruction, med, res, research, patients, intramyocardial, wright, ami, study, deferiprone, magn, reson, toronto, chelation, ventricular, therapy, cardiovascular, left, cardiol, adverse, mri, size, access,

Topics {✒️}

high-dose iron-chelator therapy month download article/chapter st-elevation-myocardial infarction identify hemorrhage-derived iron high-molecular-weight molecules intracerebral convection-enhanced delivery cardiac ischemia-reperfusion injury hsv color space–simplecolordetectionbyhue post-myocardial-infarction setting iron-chelating drug candidate myocardial ischaemia-reperfusion injury cd11/cd18 integrin receptor assess post-infarct myocardium article basic research article behrouzi ugt1a6 genotype-related pharmacokinetics hemorrhage promotes inflammation iron-chelating agent deferiprone ischemia–reperfusion injury ischemia-reperfusion injury full article pdf iron chelation therapy extracellular collagen matrix vivo validation sunnybrook research institute benjamin ej iron-chelating therapy acute myocardial infarction lugo-olivieri ch author information authors ghugre nr cardiovascular magnetic resonance myocardial reperfusion injury reperfused ami procedure week 4 post-ami magnetic resonance imaging privacy choices/manage cookies garcia-dorado subacute myocardial infarction myocardial infarction culminates previous myocardial infarction percutaneous coronary intervention left ventricular remodeling investigators halt-mi stroke statistics-2017 update stroke statistics–2012 update related subjects practical medical applications myocardial infarct size residual myocardial iron

Questions {❓}

Dharmakumar R (2016) “Rusty hearts”: is it time to rethink iron chelation therapies in post-myocardial-infarction setting?
Heusch P, Nensa F, Heusch G (2015) Is MRI really the gold standard for the quantification of salvage from myocardial infarction?
Hinder M, Yi BA, Langenickel TH (2018) Developing drugs for heart failure with reduced ejection fraction: what have we learned from clinical trials?
Jugdutt BI (2003) Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Action of iron chelator on intramyocardial hemorrhage and cardiac remodeling following acute myocardial infarction
         description:Intramyocardial hemorrhage is an independent predictor of adverse outcomes in ST-segment elevation myocardial infarction (STEMI). Iron deposition resulting from ischemia–reperfusion injury (I/R) is pro-inflammatory and has been associated with adverse remodeling. The role of iron chelation in hemorrhagic acute myocardial infarction (AMI) has never been explored. The purpose of this study was to investigate the cardioprotection offered by the iron-chelating agent deferiprone (DFP) in a porcine AMI model by evaluating hemorrhage neutralization and subsequent cardiac remodeling. Two groups of animals underwent a reperfused AMI procedure: control and DFP treated (N = 7 each). A comprehensive MRI examination was performed in healthy state and up to week 4 post-AMI, followed by histological assessment. Infarct size was not significantly different between the two groups; however, the DFP group demonstrated earlier resolution of hemorrhage (by T2* imaging) and edema (by T2 imaging). Additionally, ventricular enlargement and myocardial hypertrophy (wall thickness and mass) were significantly smaller with DFP, suggesting reduced adverse remodeling, compared to control. The histologic results were consistent with the MRI findings. To date, there is no effective targeted therapy for reperfusion hemorrhage. Our proof-of-concept study is the first to identify hemorrhage-derived iron as a therapeutic target in I/R and exploit the cardioprotective properties of an iron-chelating drug candidate in the setting of AMI. Iron chelation could potentially serve as an adjunctive therapy in hemorrhagic AMI.
         datePublished:2020-03-05T00:00:00Z
         dateModified:2020-03-05T00:00:00Z
         pageStart:1
         pageEnd:18
         sameAs:https://doi.org/10.1007/s00395-020-0782-6
         keywords:
            Myocardial infarction
            Iron chelation
            Hemorrhage
            Inflammation
            Ischemia–reperfusion injury
            Myocardial remodeling
            Cardiology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig6_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig7_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig8_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig9_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig10_HTML.png
         isPartOf:
            name:Basic Research in Cardiology
            issn:
               1435-1803
               0300-8428
            volumeNumber:115
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Bita Behrouzi
               affiliation:
                     name:University of Toronto
                     address:
                        name:Department of Physics and Physiology, University of Toronto, Toronto, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jill J. Weyers
               affiliation:
                     name:Sunnybrook Research Institute
                     address:
                        name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiuling Qi
               affiliation:
                     name:Sunnybrook Research Institute
                     address:
                        name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jennifer Barry
               affiliation:
                     name:Sunnybrook Research Institute
                     address:
                        name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Vrajlal Rabadia
               affiliation:
                     name:ApoPharma Inc
                     address:
                        name:ApoPharma Inc, Toronto, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Dino Manca
               affiliation:
                     name:ApoPharma Inc
                     address:
                        name:ApoPharma Inc, Toronto, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:John Connelly
               affiliation:
                     name:ApoPharma Inc
                     address:
                        name:ApoPharma Inc, Toronto, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Michael Spino
               affiliation:
                     name:ApoPharma Inc
                     address:
                        name:ApoPharma Inc, Toronto, Canada
                        type:PostalAddress
                     type:Organization
                     name:University of Toronto
                     address:
                        name:Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:John C. Wood
               affiliation:
                     name:Childrens Hospital Los Angeles, University of Southern California
                     address:
                        name:Childrens Hospital Los Angeles, University of Southern California, Los Angeles, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bradley H. Strauss
               affiliation:
                     name:Sunnybrook Health Sciences Centre
                     address:
                        name:Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Graham A. Wright
               affiliation:
                     name:Sunnybrook Research Institute
                     address:
                        name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
                        type:PostalAddress
                     type:Organization
                     name:Sunnybrook Health Sciences Centre
                     address:
                        name:Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Canada
                        type:PostalAddress
                     type:Organization
                     name:University of Toronto
                     address:
                        name:Department of Medical Biophysics, University of Toronto, Toronto, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nilesh R. Ghugre
               affiliation:
                     name:Sunnybrook Research Institute
                     address:
                        name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
                        type:PostalAddress
                     type:Organization
                     name:Sunnybrook Health Sciences Centre
                     address:
                        name:Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Canada
                        type:PostalAddress
                     type:Organization
                     name:University of Toronto
                     address:
                        name:Department of Medical Biophysics, University of Toronto, Toronto, Canada
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Action of iron chelator on intramyocardial hemorrhage and cardiac remodeling following acute myocardial infarction
      description:Intramyocardial hemorrhage is an independent predictor of adverse outcomes in ST-segment elevation myocardial infarction (STEMI). Iron deposition resulting from ischemia–reperfusion injury (I/R) is pro-inflammatory and has been associated with adverse remodeling. The role of iron chelation in hemorrhagic acute myocardial infarction (AMI) has never been explored. The purpose of this study was to investigate the cardioprotection offered by the iron-chelating agent deferiprone (DFP) in a porcine AMI model by evaluating hemorrhage neutralization and subsequent cardiac remodeling. Two groups of animals underwent a reperfused AMI procedure: control and DFP treated (N = 7 each). A comprehensive MRI examination was performed in healthy state and up to week 4 post-AMI, followed by histological assessment. Infarct size was not significantly different between the two groups; however, the DFP group demonstrated earlier resolution of hemorrhage (by T2* imaging) and edema (by T2 imaging). Additionally, ventricular enlargement and myocardial hypertrophy (wall thickness and mass) were significantly smaller with DFP, suggesting reduced adverse remodeling, compared to control. The histologic results were consistent with the MRI findings. To date, there is no effective targeted therapy for reperfusion hemorrhage. Our proof-of-concept study is the first to identify hemorrhage-derived iron as a therapeutic target in I/R and exploit the cardioprotective properties of an iron-chelating drug candidate in the setting of AMI. Iron chelation could potentially serve as an adjunctive therapy in hemorrhagic AMI.
      datePublished:2020-03-05T00:00:00Z
      dateModified:2020-03-05T00:00:00Z
      pageStart:1
      pageEnd:18
      sameAs:https://doi.org/10.1007/s00395-020-0782-6
      keywords:
         Myocardial infarction
         Iron chelation
         Hemorrhage
         Inflammation
         Ischemia–reperfusion injury
         Myocardial remodeling
         Cardiology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig6_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig7_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig8_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig9_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00395-020-0782-6/MediaObjects/395_2020_782_Fig10_HTML.png
      isPartOf:
         name:Basic Research in Cardiology
         issn:
            1435-1803
            0300-8428
         volumeNumber:115
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Bita Behrouzi
            affiliation:
                  name:University of Toronto
                  address:
                     name:Department of Physics and Physiology, University of Toronto, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jill J. Weyers
            affiliation:
                  name:Sunnybrook Research Institute
                  address:
                     name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiuling Qi
            affiliation:
                  name:Sunnybrook Research Institute
                  address:
                     name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jennifer Barry
            affiliation:
                  name:Sunnybrook Research Institute
                  address:
                     name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Vrajlal Rabadia
            affiliation:
                  name:ApoPharma Inc
                  address:
                     name:ApoPharma Inc, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dino Manca
            affiliation:
                  name:ApoPharma Inc
                  address:
                     name:ApoPharma Inc, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:John Connelly
            affiliation:
                  name:ApoPharma Inc
                  address:
                     name:ApoPharma Inc, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michael Spino
            affiliation:
                  name:ApoPharma Inc
                  address:
                     name:ApoPharma Inc, Toronto, Canada
                     type:PostalAddress
                  type:Organization
                  name:University of Toronto
                  address:
                     name:Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:John C. Wood
            affiliation:
                  name:Childrens Hospital Los Angeles, University of Southern California
                  address:
                     name:Childrens Hospital Los Angeles, University of Southern California, Los Angeles, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bradley H. Strauss
            affiliation:
                  name:Sunnybrook Health Sciences Centre
                  address:
                     name:Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Graham A. Wright
            affiliation:
                  name:Sunnybrook Research Institute
                  address:
                     name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
                     type:PostalAddress
                  type:Organization
                  name:Sunnybrook Health Sciences Centre
                  address:
                     name:Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Canada
                     type:PostalAddress
                  type:Organization
                  name:University of Toronto
                  address:
                     name:Department of Medical Biophysics, University of Toronto, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nilesh R. Ghugre
            affiliation:
                  name:Sunnybrook Research Institute
                  address:
                     name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
                     type:PostalAddress
                  type:Organization
                  name:Sunnybrook Health Sciences Centre
                  address:
                     name:Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Canada
                     type:PostalAddress
                  type:Organization
                  name:University of Toronto
                  address:
                     name:Department of Medical Biophysics, University of Toronto, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Basic Research in Cardiology
      issn:
         1435-1803
         0300-8428
      volumeNumber:115
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Toronto
      address:
         name:Department of Physics and Physiology, University of Toronto, Toronto, Canada
         type:PostalAddress
      name:Sunnybrook Research Institute
      address:
         name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
         type:PostalAddress
      name:Sunnybrook Research Institute
      address:
         name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
         type:PostalAddress
      name:Sunnybrook Research Institute
      address:
         name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
         type:PostalAddress
      name:ApoPharma Inc
      address:
         name:ApoPharma Inc, Toronto, Canada
         type:PostalAddress
      name:ApoPharma Inc
      address:
         name:ApoPharma Inc, Toronto, Canada
         type:PostalAddress
      name:ApoPharma Inc
      address:
         name:ApoPharma Inc, Toronto, Canada
         type:PostalAddress
      name:ApoPharma Inc
      address:
         name:ApoPharma Inc, Toronto, Canada
         type:PostalAddress
      name:University of Toronto
      address:
         name:Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
         type:PostalAddress
      name:Childrens Hospital Los Angeles, University of Southern California
      address:
         name:Childrens Hospital Los Angeles, University of Southern California, Los Angeles, USA
         type:PostalAddress
      name:Sunnybrook Health Sciences Centre
      address:
         name:Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Canada
         type:PostalAddress
      name:Sunnybrook Research Institute
      address:
         name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
         type:PostalAddress
      name:Sunnybrook Health Sciences Centre
      address:
         name:Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Canada
         type:PostalAddress
      name:University of Toronto
      address:
         name:Department of Medical Biophysics, University of Toronto, Toronto, Canada
         type:PostalAddress
      name:Sunnybrook Research Institute
      address:
         name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
         type:PostalAddress
      name:Sunnybrook Health Sciences Centre
      address:
         name:Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Canada
         type:PostalAddress
      name:University of Toronto
      address:
         name:Department of Medical Biophysics, University of Toronto, Toronto, Canada
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Bita Behrouzi
      affiliation:
            name:University of Toronto
            address:
               name:Department of Physics and Physiology, University of Toronto, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Jill J. Weyers
      affiliation:
            name:Sunnybrook Research Institute
            address:
               name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Xiuling Qi
      affiliation:
            name:Sunnybrook Research Institute
            address:
               name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Jennifer Barry
      affiliation:
            name:Sunnybrook Research Institute
            address:
               name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Vrajlal Rabadia
      affiliation:
            name:ApoPharma Inc
            address:
               name:ApoPharma Inc, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Dino Manca
      affiliation:
            name:ApoPharma Inc
            address:
               name:ApoPharma Inc, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:John Connelly
      affiliation:
            name:ApoPharma Inc
            address:
               name:ApoPharma Inc, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Michael Spino
      affiliation:
            name:ApoPharma Inc
            address:
               name:ApoPharma Inc, Toronto, Canada
               type:PostalAddress
            type:Organization
            name:University of Toronto
            address:
               name:Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:John C. Wood
      affiliation:
            name:Childrens Hospital Los Angeles, University of Southern California
            address:
               name:Childrens Hospital Los Angeles, University of Southern California, Los Angeles, USA
               type:PostalAddress
            type:Organization
      name:Bradley H. Strauss
      affiliation:
            name:Sunnybrook Health Sciences Centre
            address:
               name:Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Graham A. Wright
      affiliation:
            name:Sunnybrook Research Institute
            address:
               name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
               type:PostalAddress
            type:Organization
            name:Sunnybrook Health Sciences Centre
            address:
               name:Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Canada
               type:PostalAddress
            type:Organization
            name:University of Toronto
            address:
               name:Department of Medical Biophysics, University of Toronto, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Nilesh R. Ghugre
      affiliation:
            name:Sunnybrook Research Institute
            address:
               name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
               type:PostalAddress
            type:Organization
            name:Sunnybrook Health Sciences Centre
            address:
               name:Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Canada
               type:PostalAddress
            type:Organization
            name:University of Toronto
            address:
               name:Department of Medical Biophysics, University of Toronto, Toronto, Canada
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Physics and Physiology, University of Toronto, Toronto, Canada
      name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
      name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
      name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
      name:ApoPharma Inc, Toronto, Canada
      name:ApoPharma Inc, Toronto, Canada
      name:ApoPharma Inc, Toronto, Canada
      name:ApoPharma Inc, Toronto, Canada
      name:Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
      name:Childrens Hospital Los Angeles, University of Southern California, Los Angeles, USA
      name:Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Canada
      name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
      name:Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Canada
      name:Department of Medical Biophysics, University of Toronto, Toronto, Canada
      name:Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
      name:Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Canada
      name:Department of Medical Biophysics, University of Toronto, Toronto, Canada
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(389)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.34s.

LINK . SPRINGER . COM {}