We are analyzing https://link.springer.com/article/10.1007/s00395-016-0569-y.

Title:
Changes of myocardial gene expression and protein composition in patients with dilated cardiomyopathy after immunoadsorption with subsequent immunoglobulin substitution | Basic Research in Cardiology
Description:
Immunoadsorption with subsequent immunoglobulin substitution (IA/IgG) represents a therapeutic approach for patients with dilated cardiomyopathy (DCM). Here, we studied which molecular cardiac alterations are initiated after this treatment. Transcription profiling of endomyocardial biopsies with Affymetrix whole genome arrays was performed on 33 paired samples of DCM patients collected before and 6 months after IA/IgG. Therapy-related effects on myocardial protein levels were analysed by label-free proteome profiling for a subset of 23 DCM patients. Data were analysed regarding therapy-associated differences in gene expression and protein levels by comparing responders (defined by improvement of left ventricular ejection fraction ≥20 % relative and ≥5 % absolute) and non-responders. Responders to IA/IgG showed a decrease in serum N-terminal proBNP levels in comparison with baseline which was accompanied by a decreased expression of heart failure markers, such as angiotensin converting enzyme 2 or periostin. However, despite clinical improvement even in responders, IA/IgG did not trigger general inversion of DCM-associated molecular alterations in myocardial tissue. Transcriptome profiling revealed reduced gene expression for connective tissue growth factor, fibronectin, and collagen type I in responders. In contrast, in non-responders after IA/IgG, fibrosis-associated genes and proteins showed elevated levels, whereas values were reduced or maintained in responders. Thus, improvement of LV function after IA/IgG seems to be related to a reduced gene expression of heart failure markers and pro-fibrotic molecules as well as reduced fibrosis progression.
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Keywords {🔍}

article, pubmed, google, scholar, heart, cas, cardiomyopathy, failure, dilated, expression, cardiac, patients, pdf, myocardial, supplementary, material, gene, felix, greifswald, research, immunoadsorption, cardiol, klingel, kandolf, res, cardiology, therapy, dois, medicine, clinical, fibrosis, myocarditis, circulation, staudt, germany, european, ameling, treatment, access, eur, diagnosis, university, hammer, trimpert, iaigg, responders, ventricular, factor, chronic, clin,

Topics {✒️}

friedrich-ludwig-jahn-straße 15a month download article/chapter label-free proteome profiling fcgamma-receptor iia polymorphism mixed messages—transcription patterns article basic research left ventricular dysfunction received research support felix & uwe völker privacy choices/manage cookies full article pdf subsequent immunoglobulin substitution reduced gene expression human myocardial proteome related subjects translational research committee myocardial gene expression von kaisenberg cs ferdinand-sauerbruch-straße cardiac resynchronization therapy chronic heart failure reduced fibrosis progression american heart association marcus dörr article ameling heart failure association atrial natriuretic peptide lopez-sendon jl trigger general inversion pro-fibrotic molecules check access replicated microarray experiments prospective familial assessment poole-wilson pa pro-fibrotic markers beat-blocking agents wilson tang wh false discovery rates sdf-1 predicts mortality grant sfb/tr 19 felix-hausdorff-str instant access dilated cardiomyopathy treated german research foundation heart failure markers human heart failure dyssynchronous heart failure human heart failure conditions privacy policy myocardial contractile reserve

Questions {❓}

Heymans S, Hirsch E, Anker SD, Aukrust P, Balligand JL, Cohen-Tervaert JW, Drexler H, Filippatos G, Felix SB, Gullestad L, Hilfiker-Kleiner D, Janssens S, Latini R, Neubauer G, Paulus WJ, Pieske B, Ponikowski P, Schroen B, Schultheiss HP, Tschope C, Van Bilsen M, Zannad F, McMurray J, Shah AM (2009) Inflammation as a therapeutic target in heart failure?

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      headline:Changes of myocardial gene expression and protein composition in patients with dilated cardiomyopathy after immunoadsorption with subsequent immunoglobulin substitution
      description:Immunoadsorption with subsequent immunoglobulin substitution (IA/IgG) represents a therapeutic approach for patients with dilated cardiomyopathy (DCM). Here, we studied which molecular cardiac alterations are initiated after this treatment. Transcription profiling of endomyocardial biopsies with Affymetrix whole genome arrays was performed on 33 paired samples of DCM patients collected before and 6 months after IA/IgG. Therapy-related effects on myocardial protein levels were analysed by label-free proteome profiling for a subset of 23 DCM patients. Data were analysed regarding therapy-associated differences in gene expression and protein levels by comparing responders (defined by improvement of left ventricular ejection fraction ≥20 % relative and ≥5 % absolute) and non-responders. Responders to IA/IgG showed a decrease in serum N-terminal proBNP levels in comparison with baseline which was accompanied by a decreased expression of heart failure markers, such as angiotensin converting enzyme 2 or periostin. However, despite clinical improvement even in responders, IA/IgG did not trigger general inversion of DCM-associated molecular alterations in myocardial tissue. Transcriptome profiling revealed reduced gene expression for connective tissue growth factor, fibronectin, and collagen type I in responders. In contrast, in non-responders after IA/IgG, fibrosis-associated genes and proteins showed elevated levels, whereas values were reduced or maintained in responders. Thus, improvement of LV function after IA/IgG seems to be related to a reduced gene expression of heart failure markers and pro-fibrotic molecules as well as reduced fibrosis progression.
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         Responder
         Fibrosis
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