We are analyzing https://link.springer.com/article/10.1007/s00395-015-0498-1.

Title:
Irregular rhythm and atrial metabolism are key for the evolution of proarrhythmic atrial remodeling in atrial fibrillation | Basic Research in Cardiology
Description:
Basic Research in Cardiology -
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

atrial, pubmed, article, google, scholar, fibrillation, activation, cas, ampk, irregular, remodeling, pacing, calcium, dobrev, increased, nattel, res, patients, cardiomyocytes, effects, research, rhythm, electrical, expression, metabolism, tachycardia, central, role, heart, camkii, wang, voigt, important, cellular, rate, signaling, kinase, cardiovasc, heijman, progression, potential, pathways, compared, lenski, protein, handling, cardiol, resulting, current, mechanisms,

Topics {✒️}

amp-activated protein kinase catecholamine-synthesizing enzymes compared increased amp/atp ratios irregular-rhythm-mediated alterations l-type calcium current potential calcium-dependent mechanism cultured atrial-derived myocytes transforming growth factor-β liver kinase b1 tachycardia-induced contractile dysfunction calcium-dependent mechanism pro-apoptotic signaling pathways sarcoplasmic reticulum age-dependent development decreased cardiac output preceding diastolic interval privacy choices/manage cookies af-related remodeling calcium-handling abnormalities cardiomyocyte calcium handling calcium handling abnormalities article heijman cellular energy balance canine atrial myocytes reactive oxygen species increase energy availability transgenic mouse model increased membrane expression increased expression/activation atrial fibrillation therapeutics atrial fibrillation substrate sustained atrial fibrillation irregular pacing interval links irregular pacing irregular pacing rhythms resting membrane potential increased pulmonary wedge rectifier potassium current yeh yh underlying pathophysiological mechanisms atrial tachycardia remodeling central role human atrial fibrillation fixed pacing interval atrial pressure compared proarrhythmic atrial remodeling atrial remodeling develop atrial metabolic remodeling rhythm-control therapy higher fat expression

Questions {❓}

Heijman J, Voigt N, Ghezelbash S, Schirmer I, Dobrev D (2015) Calcium handling abnormalities as a target for atrial fibrillation therapeutics: how close to clinical implementation?
Wijesurendra RS, Casadei B (2015) Atrial fibrillation: effects beyond the atrium?

Schema {🗺️}

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