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We are analyzing https://link.springer.com/article/10.1007/s00395-009-0052-0.

Title:
Multi-slice computed tomography with N1177 identifies ruptured atherosclerotic plaques in rabbits | Basic Research in Cardiology
Description:
Rupture-prone and ruptured plaques are characterized by the presence of large numbers of macrophages. N1177 is a contrast agent consisting of iodinated nanoparticles that are selectively phagocytosed by macrophages. The aim of this study was to investigate the effect of N1177 on the CT attenuation of rupture-prone and ruptured plaques in rabbits. In addition, we examined in vitro whether uptake of N1177 occurred without cytotoxic or pro-inflammatory effects on macrophages. In vitro, the viability of J774 macrophages was not affected by treatment with N1177. Moreover, N1177 had no effect on the phagocytic capacity or cytokine production of macrophages. For the in vivo experiments, 6 New Zealand White rabbits were fed a cholesterol-supplemented diet for 12–15 months, resulting in the development of large atherosclerotic plaques that resembled rupture-prone plaques in humans. In three rabbits, mechanical plaque rupture was induced by retrograde pullback of an embolic protection device. N1177 had no effect on the median density of rupture-prone plaques [35 HU (range 3–85) before injection vs. 32 HU (range 1–93) 2 h after injection of N1177; P > 0.05]. However, after induction of mechanical plaque rupture, the median density of the atherosclerotic plaques increased from 40 HU (range 6–86) before injection to 74 HU (range 14–111) 2 h after injection of N1177 (P < 0.001). Using time-of-flight static secondary ion mass spectrometry, the presence of N1177 nanoparticles was demonstrated in macrophage-rich areas of ruptured plaques, but not of non-ruptured plaques. In conclusion, our results show that N1177 is a contrast agent that can identify ruptured atherosclerotic plaques.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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  • Education
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What CMS is link.springer.com built with?

Custom-built

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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How Does Link.springer.com Make Money? {💸}

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Keywords {🔍}

google, scholar, article, pubmed, coronary, cas, van, computed, atherosclerotic, tomography, plaques, cardiol, plaque, imaging, macrophages, basic, meyer, res, coll, rabbits, herman, lesions, research, martinet, atherosclerosis, human, cardiovasc, slice, acute, university, antwerp, multislice, ruptured, study, vivo, rupture, access, becker, characterization, cardiovascular, circulation, intravascular, ultrasound, division, belgium, privacy, cookies, content, herck, bult,

Topics {✒️}

month download article/chapter multi-slice computed tomography multi-detector-row ct multi-detector row ct dual-energy computed tomography macrophage-rich atherosclerotic plaque luc van vaeck related subjects u-king-im j roel de mondt resembled rupture-prone plaques jozef van herck article basic research coronary artery disease 64-slice computed tomography iron oxide-enhanced mri rupture-prone plaques [35 hu full article pdf acute coronary syndromes multidetector computed tomography van der pluijm quantitative coronary angiography coronary artery stenosis conventional coronary angiography privacy choices/manage cookies submillimeter computed tomography characterize atherosclerotic plaque macrophage-rich areas van de ruit coronary atherosclerotic plaques cardiac computed tomography disease biology affecting mechanical plaque rupture acute coronary syndrome human atherosclerotic plaques de meyer gry van engelshoven jma van mieghem cag van hove ce cor van hove successful molecular imaging vulnerable nonstenotic plaque quantify plaque volumes human coronary arteries annick ludwig noncalcified coronary plaques atherosclerotic plaques increased proximal coronary system coronary vessel evoked sudden coronary death

Schema {🗺️}

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         headline:Multi-slice computed tomography with N1177 identifies ruptured atherosclerotic plaques in rabbits
         description:Rupture-prone and ruptured plaques are characterized by the presence of large numbers of macrophages. N1177 is a contrast agent consisting of iodinated nanoparticles that are selectively phagocytosed by macrophages. The aim of this study was to investigate the effect of N1177 on the CT attenuation of rupture-prone and ruptured plaques in rabbits. In addition, we examined in vitro whether uptake of N1177 occurred without cytotoxic or pro-inflammatory effects on macrophages. In vitro, the viability of J774 macrophages was not affected by treatment with N1177. Moreover, N1177 had no effect on the phagocytic capacity or cytokine production of macrophages. For the in vivo experiments, 6 New Zealand White rabbits were fed a cholesterol-supplemented diet for 12–15 months, resulting in the development of large atherosclerotic plaques that resembled rupture-prone plaques in humans. In three rabbits, mechanical plaque rupture was induced by retrograde pullback of an embolic protection device. N1177 had no effect on the median density of rupture-prone plaques [35 HU (range 3–85) before injection vs. 32 HU (range 1–93) 2 h after injection of N1177; P > 0.05]. However, after induction of mechanical plaque rupture, the median density of the atherosclerotic plaques increased from 40 HU (range 6–86) before injection to 74 HU (range 14–111) 2 h after injection of N1177 (P < 0.001). Using time-of-flight static secondary ion mass spectrometry, the presence of N1177 nanoparticles was demonstrated in macrophage-rich areas of ruptured plaques, but not of non-ruptured plaques. In conclusion, our results show that N1177 is a contrast agent that can identify ruptured atherosclerotic plaques.
         datePublished:2009-08-20T00:00:00Z
         dateModified:2009-08-20T00:00:00Z
         pageStart:51
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            Multi-slice computed tomography
            N1177
            Molecular imaging
            Macrophage
            Cardiology
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      headline:Multi-slice computed tomography with N1177 identifies ruptured atherosclerotic plaques in rabbits
      description:Rupture-prone and ruptured plaques are characterized by the presence of large numbers of macrophages. N1177 is a contrast agent consisting of iodinated nanoparticles that are selectively phagocytosed by macrophages. The aim of this study was to investigate the effect of N1177 on the CT attenuation of rupture-prone and ruptured plaques in rabbits. In addition, we examined in vitro whether uptake of N1177 occurred without cytotoxic or pro-inflammatory effects on macrophages. In vitro, the viability of J774 macrophages was not affected by treatment with N1177. Moreover, N1177 had no effect on the phagocytic capacity or cytokine production of macrophages. For the in vivo experiments, 6 New Zealand White rabbits were fed a cholesterol-supplemented diet for 12–15 months, resulting in the development of large atherosclerotic plaques that resembled rupture-prone plaques in humans. In three rabbits, mechanical plaque rupture was induced by retrograde pullback of an embolic protection device. N1177 had no effect on the median density of rupture-prone plaques [35 HU (range 3–85) before injection vs. 32 HU (range 1–93) 2 h after injection of N1177; P > 0.05]. However, after induction of mechanical plaque rupture, the median density of the atherosclerotic plaques increased from 40 HU (range 6–86) before injection to 74 HU (range 14–111) 2 h after injection of N1177 (P < 0.001). Using time-of-flight static secondary ion mass spectrometry, the presence of N1177 nanoparticles was demonstrated in macrophage-rich areas of ruptured plaques, but not of non-ruptured plaques. In conclusion, our results show that N1177 is a contrast agent that can identify ruptured atherosclerotic plaques.
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      dateModified:2009-08-20T00:00:00Z
      pageStart:51
      pageEnd:59
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         Multi-slice computed tomography
         N1177
         Molecular imaging
         Macrophage
         Cardiology
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                  address:
                     name:Division of Pharmacology, University of Antwerp, Wilrijk, Belgium
                     type:PostalAddress
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            name:Wim Martinet
            affiliation:
                  name:University of Antwerp
                  address:
                     name:Division of Pharmacology, University of Antwerp, Wilrijk, Belgium
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rodrigo A. Salgado
            affiliation:
                  name:Antwerp University Hospital
                  address:
                     name:Division of Radiology, Antwerp University Hospital, Edegem, Belgium
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bharati Shivalkar
            affiliation:
                  name:Antwerp University Hospital
                  address:
                     name:Division of Cardiology, Antwerp University Hospital, Edegem, Belgium
                     type:PostalAddress
                  type:Organization
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                  name:University of Antwerp
                  address:
                     name:Division of Chemistry, University of Antwerp, Wilrijk, Belgium
                     type:PostalAddress
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            name:Helene Van De Ven
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            name:Pieter Van Der Veken
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                  name:University of Antwerp
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                     type:PostalAddress
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      name:Rodrigo A. Salgado
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            name:Antwerp University Hospital
            address:
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               type:PostalAddress
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      name:Bharati Shivalkar
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            name:Antwerp University Hospital
            address:
               name:Division of Cardiology, Antwerp University Hospital, Edegem, Belgium
               type:PostalAddress
            type:Organization
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               type:PostalAddress
            type:Organization
      name:Helene Van De Ven
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            name:University of Antwerp
            address:
               name:Division of Pharmaceutical Technology, University of Antwerp, Wilrijk, Belgium
               type:PostalAddress
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      name:Annick Ludwig
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            name:University of Antwerp
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               name:Division of Pharmaceutical Technology, University of Antwerp, Wilrijk, Belgium
               type:PostalAddress
            type:Organization
      name:Pieter Van Der Veken
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            name:University of Antwerp
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               type:PostalAddress
            type:Organization
      name:Luc Van Vaeck
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            name:University of Antwerp
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               type:PostalAddress
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      name:Hidde Bult
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            name:University of Antwerp
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               type:PostalAddress
            type:Organization
      name:Arnold G. Herman
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            name:University of Antwerp
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               type:PostalAddress
            type:Organization
      name:Christiaan J. Vrints
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            name:Antwerp University Hospital
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               name:Division of Cardiology, Antwerp University Hospital, Edegem, Belgium
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      name:Division of Cardiology, Antwerp University Hospital, Edegem, Belgium
      name:Division of Chemistry, University of Antwerp, Wilrijk, Belgium
      name:Division of Pharmaceutical Technology, University of Antwerp, Wilrijk, Belgium
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      name:Division of Medicinal Chemistry, University of Antwerp, Wilrijk, Belgium
      name:Division of Chemistry, University of Antwerp, Wilrijk, Belgium
      name:Division of Pharmacology, University of Antwerp, Wilrijk, Belgium
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      name:Division of Cardiology, Antwerp University Hospital, Edegem, Belgium
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External Links {🔗}(180)

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  • Clipboard.js
  • Particles.js
  • Prism.js

CDN Services {📦}

  • Crossref

4.84s.