We are analyzing https://link.springer.com/article/10.1007/s00395-005-0521-z.

Title:
Time course of myocardial stromal cell–derived factor 1 expression and beneficial effects of intravenously administered bone marrow stem cells in rats with experimental myocardial infarction | Basic Research in Cardiology
Description:
Objective The chemokine stromal cell–derived factor–1 (SDF–1) has been implicated in homing of bone marrow cells to sites of injury. We investigated the time course of myocardial SDF–1 expression and effects of intravenously administered bone marrow mesenchymal stem cells (MSC) in rats with myocardial infarction (MI). Methods SDF–1 expression was measured by RT–PCR and Western blot in sham operated or infarcted hearts at 1/2, 1, 2, 4, 8 and 16 days post operation. MSCs from donor rats were labeled with BrdU. A total of 5 × 106 cells in 2.5 mL of PBS or equal volume PBS alone were injected through the tail vein at above mentioned time points. The number of the labeled MSCs in the infarcted hearts was counted 3 days post injection. Cardiac function and vessel numbers were assessed 28 days post injection. Results Myocardial SDF–1 expression increased and peaked at the first day and decreased thereafter post MI and remained unchanged in sham operated hearts. The MSCs enrichment and angiogenesis in the host hearts were more abundant in the 1 day transplantation group than in the other groups (P < 0.01). Cardiac function was only improved in rats received intravenous MSCs injection within 4 days post MI and not affected by PBS injection. Conclusions Myocardial SDF–1 expression was increased only in the early phase post MI. MSCs intravenous infused at the early phase of MI were recruited to injured heart, enhanced angiogenesis and improved cardiac function.
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Keywords {🔍}

cells, google, scholar, myocardial, stem, bone, marrow, function, article, stromal, factor, mesenchymal, cell, rats, zhang, access, cellderived, expression, effects, infarction, post, circulation, privacy, cookies, content, research, basic, wang, sdf, mscs, cardiac, transplantation, ischemic, information, publish, search, time, intravenously, administered, hearts, days, injection, improved, heart, open, data, log, journal, homing, infarcted,

Topics {✒️}

mesenchymal stem/progenitor cells stromal-cell-derived factor 1 bone marrow cells marrow stromal cells stem-cell homing cell-based therapy offering month download article/chapter stem cells article basic research improved cardiac function improves cardiac function bone marrow experimental myocardial infarction derived exosomes resulted injured heart myocardial sdf–1 expression related subjects acute myocardial infarction large myocardial infarction privacy choices/manage cookies full article pdf immature hematopoietic progenitor left ventricular function mscs intravenous infused check access instant access european economic area scope submit manuscript left ventricular geometry improve neurological outcome conditions privacy policy ann thorac surg potential clinical advantages myocardial infarction long-term effects cardiac function accepting optional cookies mentioned time points ischaemic cardiomyopathy serial echocardiographic assessment cell migration main content log ischemic myocardium equal volume pbs autologous transplantation ge contributed equally journal finder publish sham operated hearts article log myocardial regeneration

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         description:The chemokine stromal cell–derived factor–1 (SDF–1) has been implicated in homing of bone marrow cells to sites of injury. We investigated the time course of myocardial SDF–1 expression and effects of intravenously administered bone marrow mesenchymal stem cells (MSC) in rats with myocardial infarction (MI). SDF–1 expression was measured by RT–PCR and Western blot in sham operated or infarcted hearts at 1/2, 1, 2, 4, 8 and 16 days post operation. MSCs from donor rats were labeled with BrdU. A total of 5 × 106 cells in 2.5 mL of PBS or equal volume PBS alone were injected through the tail vein at above mentioned time points. The number of the labeled MSCs in the infarcted hearts was counted 3 days post injection. Cardiac function and vessel numbers were assessed 28 days post injection. Myocardial SDF–1 expression increased and peaked at the first day and decreased thereafter post MI and remained unchanged in sham operated hearts. The MSCs enrichment and angiogenesis in the host hearts were more abundant in the 1 day transplantation group than in the other groups (P < 0.01). Cardiac function was only improved in rats received intravenous MSCs injection within 4 days post MI and not affected by PBS injection. Myocardial SDF–1 expression was increased only in the early phase post MI. MSCs intravenous infused at the early phase of MI were recruited to injured heart, enhanced angiogenesis and improved cardiac function.
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