We are analyzing https://link.springer.com/article/10.1007/s00394-018-01890-6.

Title:
Diet supplemented with phytochemical epigallocatechin gallate and probiotic Lactobacillus fermentum confers second generation synbiotic effects by modulating cellular immune responses and antioxidant capacity in aging mice | European Journal of Nutrition
Description:
Purpose In the present study, we systematically identified and evaluated a synbiotic combination of phytochemical epigallocatechin gallate (EGCG) and probiotic bacteria in amelioration of immunosenescence and oxidative stress in aged mice. Methods Inhibitory effects of EGCG against different bacterial species were evaluated in vitro, followed by analysis to identify potential combination of EGCG and probiotic bacteria against alleviation of oxidative and inflammatory stress ex vivo. The best synbiotic combination, vis-à-vis prebiotic and probiotic supplementation alone, was then evaluated in aged Swiss albino mice for modulation of various immunological and antioxidative parameters. Results EGCG strongly inhibited the growth of pathogenic microbes as compared to probiotic bacteria. A combination of EGCG with probiotic Lactobacillus fermentum (LF) provided evidence of additive effects in the amelioration of oxidative and inflammatory stress-induced cell death. In vivo study revealed that combined supplementation of LF and EGCG significantly enhanced neutrophil oxidative index, CD3+ cell numbers and activation status, Th1/Th2 cytokines in splenic supernatants as well as liver Nrf-2 expression in comparison with treatments with LF or EGCG alone. The combined application of EGCG and LF did not simply result in additive or synergistic effects in relation with individual treatments. Conclusion These observations suggest that EGCG could be considered as a potential prebiotic that can offer second generation synbiotic health beneficial effects for the alleviation of some of the deleterious aspects of immunosenescence and aging.
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article, google, scholar, cas, aging, probiotic, lactobacillus, sharma, egcg, kumari, cell, cells, pubmed, effects, immune, probiotics, synbiotic, mice, human, tea, journal, fermentum, gut, kapila, food, nutr, privacy, cookies, content, epigallocatechin, gallate, responses, bacteria, oxidative, access, response, microbiota, natural, authors, rhamnosus, immunol, author, publish, research, search, gupta, padwad, combination, bacterial, potential,

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month download article/chapter author information authors porcine cd3+nkp46+ lymphocytes intestinal immunity th1/th2 immune homeostasis ashu gulati & mahesh gupta balance th1/th2 cytokines modulates immune response vis-à-vis prebiotic oligofructose-enriched inulin combined anamika sharma short-term synbiotic supplementation human intestinal microbiota natural killer cells probiotic lactobacillus fermentum amita kumari lactobacillus fermentum hfb3 randomized controlled studies humoral immune responses article european journal author states potential probiotic strain full article pdf privacy choices/manage cookies engineering research board lactobacillus rhamnosus nk-cell characteristics th1/th2 cytokines green tea increases green tea extract green tea components measuring cell death synbiotics phytochemical epigallocatechin gallate intestinal microbiota immune aging process cd3+ cell numbers european economic area manuscript post-publication oxidative stress response nf-κb indigenous bacterial probiotics check access instant access article sharma aging-related diseases affect blood biochemistry anti-inflammatory activity generation synbiotic effects probiotic fruit beverages

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Krautkramer KA, Rey FE, Denu JM (2017) Chemical signaling betweengut microbiota and host chromatin: what is your gut really saying?

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