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cancer, article, google, scholar, colon, pubmed, patients, stage, cas, ratio, adjuvant, colorectal, chemotherapy, nlr, survival, neutrophillymphocyte, elevated, oncol, preoperative, access, privacy, cookies, content, journal, receive, prognosis, neutrophil, lymphocyte, fluorouracil, clin, surg, analysis, publish, search, international, predictor, trials, resection, data, information, log, research, disease, surgical, outcomes, hung, chen, yeh, jyming, chiang,

Topics {✒️}

jeng-yi wang & jy-ming chiang jy-ming chiang month download article/chapter carcinoembryonic antigen ≥5 ng/ml prognostic factor serum c-reactive protein oncology-colon cancer worse disease-free survival b2 colon cancer preoperative neutrophil–lymphocyte ratio article international journal stage ii disease prognostic significance colorectal cancer risk full article pdf privacy choices/manage cookies stage iii high blood neutrophil clinical oncology recommendations resected colon carcinoma high risk factors tumour recurrence c-reactive protein epithelial ovarian cancer colorectal disease aims related subjects chang gung university colorectal liver metastases neutrophil–lymphocyte ratio article hung colon cancer american cancer society elevated preoperative neutrophil lymphocyte counts—rapid nsabp clinical trials receive adjuvant chemotherapy european economic area chung-rong changchien pao-shiu hsieh wen-sy tasi chung-wei fan preoperative nlr measurement improving survival outcome conditions privacy policy colorectal cancer stage b2 jinn-shiun chen chien yuh yeh predict clinical outcome fu-hsing st

Questions {❓}

• Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow?
• Zaniboni A, Labianca R, Gruppo I et al (2004) Adjuvant therapy for stage II colon cancer: an elephant in the living room?

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         headline:Effect of preoperative neutrophil–lymphocyte ratio on the surgical outcomes of stage II colon cancer patients who do not receive adjuvant chemotherapy
         description:Selection of appropriate stage II colon cancer patients for adjuvant chemotherapy is critical for improving survival outcome. With the aim of identifying more high risk factors for stage II colon cancer, this study aimed to determine whether the neutrophil–lymphocyte ratio (NLR) is a predictor of surgical outcomes in patients with stage II colon cancer who do not receive adjuvant chemotherapy. We enrolled 1,040 stage II colon cancer patients who had undergone colectomy at a single institution between January 1995 and December 2005 and did not receive adjuvant chemotherapy. Of these 1,040 patients, 785 (75.5%) patients had a normal NLR and 255 (24.5%) had an elevated NLR. Those with an elevated NLR included patients ≥65 years, T4b cancer, carcinoembryonic antigen ≥5 ng/mL, and tumor obstruction or perforation. Patients with an elevated NLR had a significantly worse overall survival (OS) and worse disease-free survival (DFS) than did patients with a normal NLR. Cox regression analysis revealed that elevated NLR was an independent predictor of OS (P=0.012) but not DFS (P=0.255). An elevated NLR is an independent predictor of OS but not DFS in stage II colon cancer patients who did not receive adjuvant chemotherapy. Preoperative NLR measurement in stage II colon cancer patients may be a simple method for identifying patients with a poor prognosis who can be enrolled in further trials of adjuvant chemotherapy.
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         Hepatology
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