We are analyzing https://link.springer.com/article/10.1007/s00335-008-9136-7.

Title:
Noncoding RNA in development | Mammalian Genome
Description:
Non-protein-coding sequences increasingly dominate the genomes of multicellular organisms as their complexity increases, in contrast to protein-coding genes, which remain relatively static. Most of the mammalian genome and indeed that of all eukaryotes is expressed in a cell- and tissue-specific manner, and there is mounting evidence that much of this transcription is involved in the regulation of differentiation and development. Different classes of small and large noncoding RNAs (ncRNAs) have been shown to regulate almost every level of gene expression, including the activation and repression of homeotic genes and the targeting of chromatin-remodeling complexes. ncRNAs are involved in developmental processes in both simple and complex eukaryotes, and we illustrate this in the latter by focusing on the animal germline, brain, and eye. While most have yet to be systematically studied, the emerging evidence suggests that there is a vast hidden layer of regulatory ncRNAs that constitutes the majority of the genomic programming of multicellular organisms and plays a major role in controlling the epigenetic trajectories that underlie their ontogeny.
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Keywords {🔍}

pubmed, google, scholar, cas, central, rna, cell, noncoding, gene, biol, human, rnas, genome, mol, genet, res, genes, antisense, transcription, development, expression, dev, nat, nature, transcripts, mouse, science, drosophila, small, sci, regulation, microrna, cells, identification, micrornas, natl, acad, usa, mammalian, proc, complex, analysis, mattick, silencing, function, role, transcriptional, chromosome, evolution, dna,

Topics {✒️}

prader-willi/angelman syndrome region kruppel-type zinc-finger genes double-stranded rna-mediated silencing snail1-induced epithelial-mesenchymal transition intronic u50 small-nucleolar-rna ic-snurf-snrpn transcript serves anti-neural rest/scp1 pathway month download article/chapter cajal body-specific rnas shared cis-regulatory element polycomb/trithorax response elements full-length cdna clones prader-willi phenotype caused australian research council genome-wide high-resolution mapping providing high-resolution images homeobox protein hox-a11 protein-rna interaction modules c-type natriuretic peptide transcription factor c-myb riken arabidopsis full-length rna-binding protein translin human beta-globin locus cis-natural antisense transcripts large-scale transcriptional activity high-density tiling arrays peg3/usp29 imprinted domain massive-scale mrna sequencing rna-guided dna assembly beta-globin intergenic transcription prader-willi syndrome mammalian dlk1-dio3 domain primate-specific functional rnas dlk-dio3 genomic region plasmodium falciparum-infected erythrocytes c-erba mrna splicing candidate tumor-suppressor gene germ cell-specific mrna k-box-class micrornas rnai-dependent h3k27 methylation iab-7 cis-regulatory domain natural antisense hif-1alpha naturally occurring antisense rna-binding protein essential coding interfering transcript x-chromosome-wide profiling bc1 rna-deleted mice meiosis-specific genes identifies rna-dependent nuclear matrix imprinted x-chromosome inactivation

Questions {❓}

5% ‘junk’ in mammalian genomes?
Angelopoulou R, Lavranos G, Manolakou P (2008) Regulatory RNAs and chromatin modification in dosage compensation: a continuous path from flies to humans?
Dahary D, Elroy-Stein O, Sorek R (2005) Naturally occurring antisense: transcriptional leakage or real overlap?
Filipowicz W, Bhattacharyya SN, Sonenberg N (2008) Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
Lempradl A, Ringrose L (2008) How does noncoding transcription regulate Hox genes?
Margueron R, Trojer P, Reinberg D (2005) The key to development: interpreting the histone code?
Mattick JS (2004) RNA regulation: a new genetics?
Ponjavic J, Ponting CP, Lunter G (2007) Functionality or transcriptional noise?

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