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Spinal cord lesions in patients with neuromyelitis optica: a retrospective long-term MRI follow-up study | European Radiology
Description:
Neuromyelitis optica (NMO) is characterised by a particular pattern of the optic nerves and the spinal cord. Long-term MRI follow-up studies of spinal NMO lesions are rare, or limited by short observation periods. In nine patients with definite NMO or recurrent longitudinally extensive transverse myelitis (LETM) with NMO-IgG serum antibodies, repeated MRI examinations of the spine were carried out over a period of up to 11 years and evaluated regarding the changes over time in this retrospective study. In eight patients spinal cord lesions were located centrally, involving the grey and white matter. In the first examination after clinical onset changes resembled a stroke of the anterior spinal artery in two patients. Symmetrical signal alterations within the grey matter were observed. In one patient this pattern was transient, but it remained in the other. During the chronic stage, either a variable degree of spinal cord atrophy and high signal alterations, or almost complete remission of the lesions, was observed. Spinal MRI of patients with NMO myelitis can resemble a stroke. MRI of acute NMO stages did not allow a prediction of the clinical outcome. To a variable degree, NMO left behind typical defects which correlated with the clinical outcome.
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article, google, scholar, spinal, pubmed, neuromyelitis, optica, cord, cas, mri, stroke, patients, nmo, lesions, aboulenein, clinical, neurology, privacy, cookies, content, wolfgang, access, wingerchuk, brain, publish, search, longterm, followup, krampla, myelitis, matter, artery, spectrum, infarction, disease, lennon, neurol, oxford, department, vienna, austria, data, european, information, log, journal, research, radiology, retrospective, study,
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disease long-term follow month download article/chapter long-term mri follow inflammatory brain disease spinal cord lesions white matter damage multiple sclerosis spinal cord atrophy spinal cord infarction nmo-igg serum antibodies anterior spinal artery white matter inflammatory brain diseases spinal nmo lesions full article pdf european economic area spinal cord tissue injury privacy choices/manage cookies repeated mri examinations fahmy aboul-enein spinal mri wingerchuk dm short observation periods vertebral body ischemia serum autoantibody marker vertebral body infarction vascular diseases high signal alterations revised diagnostic criteria echo-planar dwi bright dorsal columns smz-ost donauspital wolfgang krampla article krampla symmetrical signal alterations acute nmo stages glycoprotein reflects hypoxia conditions privacy policy accepting optional cookies study neuro published secondary progressive clinical long term oxford university press latin american patients aboul-enein article log grey matter journal finder publish lucchinetti cf
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- Aboul-Enein F, Lassmann H (2005) Mitochondrial damage and histotoxic hypoxia: a pathway of tissue injury in inflammatory brain disease?
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headline:Spinal cord lesions in patients with neuromyelitis optica: a retrospective long-term MRI follow-up study
description:Neuromyelitis optica (NMO) is characterised by a particular pattern of the optic nerves and the spinal cord. Long-term MRI follow-up studies of spinal NMO lesions are rare, or limited by short observation periods. In nine patients with definite NMO or recurrent longitudinally extensive transverse myelitis (LETM) with NMO-IgG serum antibodies, repeated MRI examinations of the spine were carried out over a period of up to 11 years and evaluated regarding the changes over time in this retrospective study. In eight patients spinal cord lesions were located centrally, involving the grey and white matter. In the first examination after clinical onset changes resembled a stroke of the anterior spinal artery in two patients. Symmetrical signal alterations within the grey matter were observed. In one patient this pattern was transient, but it remained in the other. During the chronic stage, either a variable degree of spinal cord atrophy and high signal alterations, or almost complete remission of the lesions, was observed. Spinal MRI of patients with NMO myelitis can resemble a stroke. MRI of acute NMO stages did not allow a prediction of the clinical outcome. To a variable degree, NMO left behind typical defects which correlated with the clinical outcome.
datePublished:2009-05-05T00:00:00Z
dateModified:2009-05-05T00:00:00Z
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Neuromyelitis optica
Devic’s disease
Long-term follow-up
Snake eyes
Spinal stroke
Imaging / Radiology
Diagnostic Radiology
Interventional Radiology
Neuroradiology
Ultrasound
Internal Medicine
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headline:Spinal cord lesions in patients with neuromyelitis optica: a retrospective long-term MRI follow-up study
description:Neuromyelitis optica (NMO) is characterised by a particular pattern of the optic nerves and the spinal cord. Long-term MRI follow-up studies of spinal NMO lesions are rare, or limited by short observation periods. In nine patients with definite NMO or recurrent longitudinally extensive transverse myelitis (LETM) with NMO-IgG serum antibodies, repeated MRI examinations of the spine were carried out over a period of up to 11 years and evaluated regarding the changes over time in this retrospective study. In eight patients spinal cord lesions were located centrally, involving the grey and white matter. In the first examination after clinical onset changes resembled a stroke of the anterior spinal artery in two patients. Symmetrical signal alterations within the grey matter were observed. In one patient this pattern was transient, but it remained in the other. During the chronic stage, either a variable degree of spinal cord atrophy and high signal alterations, or almost complete remission of the lesions, was observed. Spinal MRI of patients with NMO myelitis can resemble a stroke. MRI of acute NMO stages did not allow a prediction of the clinical outcome. To a variable degree, NMO left behind typical defects which correlated with the clinical outcome.
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Devic’s disease
Long-term follow-up
Snake eyes
Spinal stroke
Imaging / Radiology
Diagnostic Radiology
Interventional Radiology
Neuroradiology
Ultrasound
Internal Medicine
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