We are analyzing https://link.springer.com/article/10.1007/s00296-012-2609-8.

Title:
The association of TNFRSF1A gene and MEFV gene mutations with adult onset Still’s disease | Rheumatology International
Description:
Adult onset Still’s disease (ASD) is a systemic inflammatory disorder of unknown etiology. ASD is characterized by fever with unknown etiology, rash, arthritis, and involvement of several organ systems. FMF and TRAPS are two important autoinflammatory diseases which characterized with recurrent inflammatory attacks. We aimed in this study to investigate the MEFV gene and TNFRSF1A gene variations in ASD. Twenty consecutive Turkish ASD patients (14 female and 6 male; mean age 38.45 ± 14; mean disease duration 3.3 ± 2.3; mean age of the disease onset 35.1 ± 14.4) and 103 healthy controls of Turkish origin were analyzed. All ASD patients were genotyped for the 4 MEFV mutations (M694V, E148Q, V726A, M680I) and TNFRSF1A gene exon 2–3 and exon 4–5 by using sequence analysis. The healthy controls are genotyped using PCR–RFLP method for intron 4 variation. The results of MEFV gene mutations screening show an increase in the MEFV mutation rate in ASD group, but it was not significantly different (p = 0.442, OR 1.64, 95 % CI 0.409–6.589). T–C polymorphism (rs1800692) was the only variation in the intron 4 of TNFRSF1A gene that we observed at the ASD patients. The frequency of TT genotype was 15 %, TC: 45 %, and CC: 40 % in ASD patients and the frequencies were 22, 41, and 37 % in healthy controls, respectively. When we analyzed the allele difference between both groups, there was no difference (p = 0.54, OR 1.24, 0.619–2.496–2.654). The variations in MEFV may have role in ASD pathogenesis. Our findings suggest that there is no significant association between ASD and TNFRSF1A variations.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Education
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,625,932 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

article, google, scholar, pubmed, gene, cas, mefv, arthritis, disease, fever, periodic, mutations, syndrome, factor, tnfrsfa, asd, patients, necrosis, stills, mediterranean, tumor, onset, rheumatol, rheum, adult, traps, receptor, familial, receptorassociated, autoinflammatory, powell, cosan, mutation, clinical, mcdermott, kastner, privacy, cookies, content, association, evidence, tnf, clin, aksentijevich, todd, publish, research, search, rheumatology, fulya,

Topics {✒️}

month download article/chapter tumor-necrosis-factor receptor auto-inflammatory fever syndromes potential disease-modifying effect neslihan abaci & duran ustek familial mediterranean fever mediterranean fever gene autoinflammatory disorders full article pdf hereditary recurrent fevers experimental medical research nuclear factor-kappa bridges sl jr privacy choices/manage cookies show abnormal behaviour juvenile idiopathic arthritis mefv mutation rate recurrent inflammatory attacks systemic inflammatory disorder periodic fever syndrome 55 kda tnf receptor tnfrsf1a gene variations mefv gene mutations related subjects rheumatoid arthritis carrying mefv messenger rna european economic area pcr–rflp method henoch-schönlein purpura ozçakar zb childhood polyarteritis nodosa amel-kashipaz mr lachmann hj janssens-korpola pl primary human fibroblasts periodic syndrome phenotypes lobito aa article cosan sema sirma ekmekci schroeder hw jr draper-morgan ka mefv mutations modify van amstel hk genotype-phenotype studies carneiro-sampaio mm conditions privacy policy accepting optional cookies important autoinflammatory diseases monogenic autoinflammatory diseases manifesting adult-onset

Questions {❓}

Giaglis S, Mimidis K, Papadopoulos V, Thomopoulos K, Sidiropoulos P, Rafail S, Nikolopoulou V, Fragouli E, Kartalis G, Tzioufas A, Boumpas D, Ritis K (2006) Increased frequency of mutations in the gene responsible for familial Mediterranean fever (MEFV) in a cohort of patients with ulcerative colitis: evidence for a potential disease-modifying effect?
Grateau G, Duruöz MT (2010) Autoinflammatory conditions: when to suspect?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The association of TNFRSF1A gene and MEFV gene mutations with adult onset Still’s disease
         description:Adult onset Still’s disease (ASD) is a systemic inflammatory disorder of unknown etiology. ASD is characterized by fever with unknown etiology, rash, arthritis, and involvement of several organ systems. FMF and TRAPS are two important autoinflammatory diseases which characterized with recurrent inflammatory attacks. We aimed in this study to investigate the MEFV gene and TNFRSF1A gene variations in ASD. Twenty consecutive Turkish ASD patients (14 female and 6 male; mean age 38.45 ± 14; mean disease duration 3.3 ± 2.3; mean age of the disease onset 35.1 ± 14.4) and 103 healthy controls of Turkish origin were analyzed. All ASD patients were genotyped for the 4 MEFV mutations (M694V, E148Q, V726A, M680I) and TNFRSF1A gene exon 2–3 and exon 4–5 by using sequence analysis. The healthy controls are genotyped using PCR–RFLP method for intron 4 variation. The results of MEFV gene mutations screening show an increase in the MEFV mutation rate in ASD group, but it was not significantly different (p = 0.442, OR 1.64, 95 % CI 0.409–6.589). T–C polymorphism (rs1800692) was the only variation in the intron 4 of TNFRSF1A gene that we observed at the ASD patients. The frequency of TT genotype was 15 %, TC: 45 %, and CC: 40 % in ASD patients and the frequencies were 22, 41, and 37 % in healthy controls, respectively. When we analyzed the allele difference between both groups, there was no difference (p = 0.54, OR 1.24, 0.619–2.496–2.654). The variations in MEFV may have role in ASD pathogenesis. Our findings suggest that there is no significant association between ASD and TNFRSF1A variations.
         datePublished:2012-12-27T00:00:00Z
         dateModified:2012-12-27T00:00:00Z
         pageStart:1675
         pageEnd:1680
         sameAs:https://doi.org/10.1007/s00296-012-2609-8
         keywords:
            Adult onset Still’s disease
            Familial Mediterranean fever
            TRAPS
            TNFRSF1A gene
            MEFV gene
            Rheumatology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00296-012-2609-8/MediaObjects/296_2012_2609_Fig1_HTML.gif
         isPartOf:
            name:Rheumatology International
            issn:
               1437-160X
               0172-8172
            volumeNumber:33
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Fulya Cosan
               affiliation:
                     name:Kocaeli University
                     address:
                        name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
                        type:PostalAddress
                     type:Organization
                     name:Istanbul University
                     address:
                        name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Zeliha Emrence
               affiliation:
                     name:Istanbul University
                     address:
                        name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gokhan Erbag
               affiliation:
                     name:Kocaeli University
                     address:
                        name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hulya Azakli
               affiliation:
                     name:Istanbul University
                     address:
                        name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Baris Yilmazer
               affiliation:
                     name:Kocaeli University
                     address:
                        name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ayten Yazici
               affiliation:
                     name:Kocaeli University
                     address:
                        name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sema Sirma Ekmekci
               affiliation:
                     name:Istanbul University
                     address:
                        name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Neslihan Abaci
               affiliation:
                     name:Istanbul University
                     address:
                        name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Duran Ustek
               affiliation:
                     name:Istanbul University
                     address:
                        name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ayse Cefle
               affiliation:
                     name:Kocaeli University
                     address:
                        name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The association of TNFRSF1A gene and MEFV gene mutations with adult onset Still’s disease
      description:Adult onset Still’s disease (ASD) is a systemic inflammatory disorder of unknown etiology. ASD is characterized by fever with unknown etiology, rash, arthritis, and involvement of several organ systems. FMF and TRAPS are two important autoinflammatory diseases which characterized with recurrent inflammatory attacks. We aimed in this study to investigate the MEFV gene and TNFRSF1A gene variations in ASD. Twenty consecutive Turkish ASD patients (14 female and 6 male; mean age 38.45 ± 14; mean disease duration 3.3 ± 2.3; mean age of the disease onset 35.1 ± 14.4) and 103 healthy controls of Turkish origin were analyzed. All ASD patients were genotyped for the 4 MEFV mutations (M694V, E148Q, V726A, M680I) and TNFRSF1A gene exon 2–3 and exon 4–5 by using sequence analysis. The healthy controls are genotyped using PCR–RFLP method for intron 4 variation. The results of MEFV gene mutations screening show an increase in the MEFV mutation rate in ASD group, but it was not significantly different (p = 0.442, OR 1.64, 95 % CI 0.409–6.589). T–C polymorphism (rs1800692) was the only variation in the intron 4 of TNFRSF1A gene that we observed at the ASD patients. The frequency of TT genotype was 15 %, TC: 45 %, and CC: 40 % in ASD patients and the frequencies were 22, 41, and 37 % in healthy controls, respectively. When we analyzed the allele difference between both groups, there was no difference (p = 0.54, OR 1.24, 0.619–2.496–2.654). The variations in MEFV may have role in ASD pathogenesis. Our findings suggest that there is no significant association between ASD and TNFRSF1A variations.
      datePublished:2012-12-27T00:00:00Z
      dateModified:2012-12-27T00:00:00Z
      pageStart:1675
      pageEnd:1680
      sameAs:https://doi.org/10.1007/s00296-012-2609-8
      keywords:
         Adult onset Still’s disease
         Familial Mediterranean fever
         TRAPS
         TNFRSF1A gene
         MEFV gene
         Rheumatology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00296-012-2609-8/MediaObjects/296_2012_2609_Fig1_HTML.gif
      isPartOf:
         name:Rheumatology International
         issn:
            1437-160X
            0172-8172
         volumeNumber:33
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Fulya Cosan
            affiliation:
                  name:Kocaeli University
                  address:
                     name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
                     type:PostalAddress
                  type:Organization
                  name:Istanbul University
                  address:
                     name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Zeliha Emrence
            affiliation:
                  name:Istanbul University
                  address:
                     name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gokhan Erbag
            affiliation:
                  name:Kocaeli University
                  address:
                     name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hulya Azakli
            affiliation:
                  name:Istanbul University
                  address:
                     name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Baris Yilmazer
            affiliation:
                  name:Kocaeli University
                  address:
                     name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ayten Yazici
            affiliation:
                  name:Kocaeli University
                  address:
                     name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sema Sirma Ekmekci
            affiliation:
                  name:Istanbul University
                  address:
                     name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Neslihan Abaci
            affiliation:
                  name:Istanbul University
                  address:
                     name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Duran Ustek
            affiliation:
                  name:Istanbul University
                  address:
                     name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ayse Cefle
            affiliation:
                  name:Kocaeli University
                  address:
                     name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Rheumatology International
      issn:
         1437-160X
         0172-8172
      volumeNumber:33
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Kocaeli University
      address:
         name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
         type:PostalAddress
      name:Istanbul University
      address:
         name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
         type:PostalAddress
      name:Istanbul University
      address:
         name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
         type:PostalAddress
      name:Kocaeli University
      address:
         name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
         type:PostalAddress
      name:Istanbul University
      address:
         name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
         type:PostalAddress
      name:Kocaeli University
      address:
         name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
         type:PostalAddress
      name:Kocaeli University
      address:
         name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
         type:PostalAddress
      name:Istanbul University
      address:
         name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
         type:PostalAddress
      name:Istanbul University
      address:
         name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
         type:PostalAddress
      name:Istanbul University
      address:
         name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
         type:PostalAddress
      name:Kocaeli University
      address:
         name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Fulya Cosan
      affiliation:
            name:Kocaeli University
            address:
               name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
               type:PostalAddress
            type:Organization
            name:Istanbul University
            address:
               name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Zeliha Emrence
      affiliation:
            name:Istanbul University
            address:
               name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
               type:PostalAddress
            type:Organization
      name:Gokhan Erbag
      affiliation:
            name:Kocaeli University
            address:
               name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
               type:PostalAddress
            type:Organization
      name:Hulya Azakli
      affiliation:
            name:Istanbul University
            address:
               name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
               type:PostalAddress
            type:Organization
      name:Baris Yilmazer
      affiliation:
            name:Kocaeli University
            address:
               name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
               type:PostalAddress
            type:Organization
      name:Ayten Yazici
      affiliation:
            name:Kocaeli University
            address:
               name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
               type:PostalAddress
            type:Organization
      name:Sema Sirma Ekmekci
      affiliation:
            name:Istanbul University
            address:
               name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
               type:PostalAddress
            type:Organization
      name:Neslihan Abaci
      affiliation:
            name:Istanbul University
            address:
               name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
               type:PostalAddress
            type:Organization
      name:Duran Ustek
      affiliation:
            name:Istanbul University
            address:
               name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
               type:PostalAddress
            type:Organization
      name:Ayse Cefle
      affiliation:
            name:Kocaeli University
            address:
               name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
      name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
      name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
      name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
      name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
      name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
      name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
      name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
      name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
      name:Division of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
      name:Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(140)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.08s.

LINK . SPRINGER . COM {}