LINK . SPRINGER . COM {
}
Title:
Fission yeast Tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature | Current Genetics
Description:
A target of rapamycin (TOR) protein is a protein kinase that exerts cellular signal transduction to regulate cell growth in response to extracellular nutrient conditions. In the Schizosaccharomyces pombe genome database, there are two genes encoding TOR-related proteins, but their functions have not been analyzed. Here we report that one of the genes, referred to as tor1 + , is required for sexual development induced by nitrogen starvation. Ste11 is a key transcription factor for the initiation of sexual development. The expression of ste11 + is normally regulated in tor1 – cells; and over-expression of ste11 + hardly rescues the defect in fertility in tor1 – . Upon nitrogen starvation, tor1 + cells promote two rounds of the cell cycle to become arrested at the G1 phase before initiation of sexual development. The tor1 – cells do not promote such a cell cycle, suggesting that Tor1 is necessary for the response to nitrogen starvation. The tor1 – cells show no growth or very slow growth under various stress conditions, including external high pH, high concentrations of salts or sorbitol, and high temperature. These results suggest that Tor1 is necessary for any response to a wide range of stresses. The vegetative growth of tor1 – cells is inhibited by rapamycin, although tor1 + cells are resistant to the drug. The tor1 – cells are hypersensitive to fluphenazine and cyclosporin A, which specifically inhibit calmodulin and calcineurin, respectively.
Website Age:
28 years and 1 months (reg. 1997-05-29).
Matching Content Categories {📚}
- Science
- Telecommunications
- Education
Content Management System {📝}
What CMS is link.springer.com built with?
Custom-built
No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of link.springer.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Link.springer.com Make Money? {💸}
We see no obvious way the site makes money.
Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.
Keywords {🔍}
tor, article, response, nitrogen, starvation, high, cells, access, privacy, cookies, content, yeast, including, information, publish, search, cell, growth, shizuoka, data, log, journal, research, fission, functions, stresses, temperature, conditions, schizosaccharomyces, pombe, genes, sexual, development, ste, cycle, stress, open, discover, japan, springer, optional, personal, parties, policy, find, track, current, genetics, osmolarity, cite,
Topics {✒️}
month download article/chapter related subjects privacy choices/manage cookies full article pdf stress conditions nitrogen starvation response key transcription factor european economic area scope submit manuscript specifically inhibit calmodulin check access instant access extracellular nutrient conditions conditions privacy policy accepting optional cookies protein kinase cell cycle transition sexual development induced doi bioasymmetry project main content log regulate cell growth nitrogen starvation journal finder publish tor article log article cite yeast high temperature privacy policy personal data books a functions optional cookies information manage preferences drug tor1 – cells tor1 + cells cell cycle article high osmolarity high concentrations sexual development data protection meiotic genes essential cookies cookies skip subscription content similar content g1 phase
Schema {🗺️}
WebPage:
mainEntity:
headline:Fission yeast Tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature
description: A target of rapamycin (TOR) protein is a protein kinase that exerts cellular signal transduction to regulate cell growth in response to extracellular nutrient conditions. In the Schizosaccharomyces pombe genome database, there are two genes encoding TOR-related proteins, but their functions have not been analyzed. Here we report that one of the genes, referred to as tor1
+
, is required for sexual development induced by nitrogen starvation. Ste11 is a key transcription factor for the initiation of sexual development. The expression of ste11
+
is normally regulated in tor1
–
cells; and over-expression of ste11
+
hardly rescues the defect in fertility in tor1
–
. Upon nitrogen starvation, tor1
+
cells promote two rounds of the cell cycle to become arrested at the G1 phase before initiation of sexual development. The tor1
–
cells do not promote such a cell cycle, suggesting that Tor1 is necessary for the response to nitrogen starvation. The tor1
–
cells show no growth or very slow growth under various stress conditions, including external high pH, high concentrations of salts or sorbitol, and high temperature. These results suggest that Tor1 is necessary for any response to a wide range of stresses. The vegetative growth of tor1
–
cells is inhibited by rapamycin, although tor1
+
cells are resistant to the drug. The tor1
–
cells are hypersensitive to fluphenazine and cyclosporin A, which specifically inhibit calmodulin and calcineurin, respectively.
datePublished:
dateModified:
pageStart:166
pageEnd:174
sameAs:https://doi.org/10.1007/s002940100198
keywords:
Schizosaccharomyces pombe Stress response TOR Nitrogen starvation
Microbial Genetics and Genomics
Microbiology
Biochemistry
general
Cell Biology
Plant Sciences
Proteomics
image:
isPartOf:
name:Current Genetics
issn:
1432-0983
0172-8083
volumeNumber:39
type:
Periodical
PublicationVolume
publisher:
name:Springer-Verlag
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:
affiliation:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
type:Organization
type:Person
name:
affiliation:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
type:Organization
type:Person
name:
affiliation:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
type:Organization
type:Person
name:
affiliation:
name:Department of Biology and Geoscience, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka 422-8529, Japan
address:
name:Department of Biology and Geoscience, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka 422-8529, Japan,
type:PostalAddress
type:Organization
type:Person
name:
affiliation:
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan
address:
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan,
type:PostalAddress
type:Organization
type:Person
name:
affiliation:
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan
address:
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan,
type:PostalAddress
type:Organization
type:Person
name:
affiliation:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
type:Organization
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Fission yeast Tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature
description: A target of rapamycin (TOR) protein is a protein kinase that exerts cellular signal transduction to regulate cell growth in response to extracellular nutrient conditions. In the Schizosaccharomyces pombe genome database, there are two genes encoding TOR-related proteins, but their functions have not been analyzed. Here we report that one of the genes, referred to as tor1
+
, is required for sexual development induced by nitrogen starvation. Ste11 is a key transcription factor for the initiation of sexual development. The expression of ste11
+
is normally regulated in tor1
–
cells; and over-expression of ste11
+
hardly rescues the defect in fertility in tor1
–
. Upon nitrogen starvation, tor1
+
cells promote two rounds of the cell cycle to become arrested at the G1 phase before initiation of sexual development. The tor1
–
cells do not promote such a cell cycle, suggesting that Tor1 is necessary for the response to nitrogen starvation. The tor1
–
cells show no growth or very slow growth under various stress conditions, including external high pH, high concentrations of salts or sorbitol, and high temperature. These results suggest that Tor1 is necessary for any response to a wide range of stresses. The vegetative growth of tor1
–
cells is inhibited by rapamycin, although tor1
+
cells are resistant to the drug. The tor1
–
cells are hypersensitive to fluphenazine and cyclosporin A, which specifically inhibit calmodulin and calcineurin, respectively.
datePublished:
dateModified:
pageStart:166
pageEnd:174
sameAs:https://doi.org/10.1007/s002940100198
keywords:
Schizosaccharomyces pombe Stress response TOR Nitrogen starvation
Microbial Genetics and Genomics
Microbiology
Biochemistry
general
Cell Biology
Plant Sciences
Proteomics
image:
isPartOf:
name:Current Genetics
issn:
1432-0983
0172-8083
volumeNumber:39
type:
Periodical
PublicationVolume
publisher:
name:Springer-Verlag
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:
affiliation:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
type:Organization
type:Person
name:
affiliation:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
type:Organization
type:Person
name:
affiliation:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
type:Organization
type:Person
name:
affiliation:
name:Department of Biology and Geoscience, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka 422-8529, Japan
address:
name:Department of Biology and Geoscience, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka 422-8529, Japan,
type:PostalAddress
type:Organization
type:Person
name:
affiliation:
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan
address:
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan,
type:PostalAddress
type:Organization
type:Person
name:
affiliation:
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan
address:
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan,
type:PostalAddress
type:Organization
type:Person
name:
affiliation:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
type:Organization
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Current Genetics
issn:
1432-0983
0172-8083
volumeNumber:39
Organization:
name:Springer-Verlag
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
name:Department of Biology and Geoscience, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka 422-8529, Japan
address:
name:Department of Biology and Geoscience, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka 422-8529, Japan,
type:PostalAddress
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan
address:
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan,
type:PostalAddress
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan
address:
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan,
type:PostalAddress
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:
affiliation:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
type:Organization
name:
affiliation:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
type:Organization
name:
affiliation:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
type:Organization
name:
affiliation:
name:Department of Biology and Geoscience, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka 422-8529, Japan
address:
name:Department of Biology and Geoscience, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka 422-8529, Japan,
type:PostalAddress
type:Organization
name:
affiliation:
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan
address:
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan,
type:PostalAddress
type:Organization
name:
affiliation:
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan
address:
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan,
type:PostalAddress
type:Organization
name:
affiliation:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan
address:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
type:PostalAddress
type:Organization
PostalAddress:
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
name:Department of Biology and Geoscience, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka 422-8529, Japan,
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan,
name:Doi Bioasymmetry Project, ERATO, JST, Tokodai 5-9-9, Tsukuba 300-2635, Japan,
name:Department of Chemistry, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka, 422-8529, Japan,
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(25)
- Revenue of https://www.springernature.com/gp/authors
- Discover the revenue of https://link.springernature.com/home/
- How much does https://order.springer.com/public/cart make?
- How much does https://submission.nature.com/new-submission/294/3 bring in each month?
- How much does https://www.springernature.com/gp/librarians/licensing/agc/journals rake in every month?
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=%20's financial summary
- How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22%20%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- Learn about the earnings of https://s100.copyright.com/AppDispatchServlet?title=Fission%20yeast%20Tor1%20functions%20in%20response%20to%20various%20stresses%20including%20nitrogen%20starvation%2C%20high%20osmolarity%2C%20and%20high%20temperature&author=%20%20et%20al&contentID=10.1007%2Fs002940100198©right=Springer-Verlag&publication=0172-8083&publicationDate=2001-05&publisherName=SpringerNature&orderBeanReset=true
- How much revenue does https://citation-needed.springer.com/v2/references/10.1007/s002940100198?format=refman&flavour=citation generate?
- What are the total earnings of https://authorservices.springernature.com/go/sn/?utm_source=SNLinkfooter&utm_medium=Web&utm_campaign=SNReferral?
- How much revenue does https://www.springernature.com/gp/open-research/about/the-fundamentals-of-open-access-and-open-research bring in?
- What are the total earnings of https://www.springernature.com/gp/products?
- How much profit is https://www.springernature.com/gp/librarians making per month?
- What's the profit of https://www.springernature.com/gp/societies?
- How much cash flow does https://www.springernature.com/gp/partners have monthly?
- What's the financial intake of https://www.springer.com/?
- What's https://www.nature.com/'s gross income?
- What's the financial intake of https://www.biomedcentral.com/?
- https://www.palgrave.com/'s financial summary
- Profit of https://www.apress.com/
- Learn about the earnings of https://www.springernature.com/gp/legal/ccpa
- How much revenue does https://www.springernature.com/gp/info/accessibility produce monthly?
- What's the profit of https://support.springernature.com/en/support/home?
- Monthly income for https://support.springernature.com/en/support/solutions/articles/6000255911-subscription-cancellations
- How much does https://www.springernature.com/ net monthly?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Clipboard.js
- Prism.js
CDN Services {📦}
- Crossref