We are analyzing https://link.springer.com/article/10.1007/s00281-018-0705-x.

Title:
Picket-fences in the plasma membrane: functions in immune cells and phagocytosis | Seminars in Immunopathology
Description:
Recent studies of molecular mobility in the plasma membrane have revealed that diffusion is restricted by cytoskeletal networks or fences. Transmembrane protein “pickets” that reversibly associate with the membrane-associated skeleton and with the pericellular coat impede the movement of unattached bystander molecules. While membrane picket-fences were originally described as barriers to free diffusion in more passive cell types such as fibroblasts, they have particularly important functions in the more dynamic immune cells. In phagocytes, such fences curtail spontaneous activation and their disassembly facilitates stimulation by target particles, fostering receptor clustering and the exclusion of phosphatases from the phagocytic cup. In this review, we describe the nature of the cellular cytoskeleton and of the exoskeleton created by the pericellular coat, their association with transmembrane pickets, and the modulation of molecular mobility during phagocytosis.
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Keywords {🔍}

pubmed, article, google, scholar, cas, cell, central, biol, membrane, phagocytosis, actin, grinstein, nat, cells, diffusion, protein, signaling, receptor, rev, immunol, proteins, mol, rac, cytoskeleton, plasma, activation, nature, freeman, chem, van, kinase, binding, science, sci, macrophage, kusumi, curr, function, research, cytoskeletal, access, regulation, model, formation, integrin, fujiwara, dev, spectrin, control, privacy,

Topics {✒️}

high-speed single-molecule tracking single-particle tracking month download article/chapter rac/cdc42 gtpase-activating proteins chemokine-induced macrophage migration fc receptor-mediated binding galectin-9 binds igm-bcr integrin alpha/src signaling syk protein-tyrosine kinase receptor-induced actin remodeling phospholipase c-mediated hydrolysis g-protein-coupled receptor fcrn/heterodimeric fc complex phospholipase c-gamma1 interacts alphavbeta5 integrin-mediated phagocytosis fc receptor-mediated phagocytosis rho-dependent signaling pathway full article pdf molecular-weight-dependent function promote fcgammar-mediated phagocytosis single-molecule techniques assembly factor competition phosphorylated ydxv motifs b-cell receptor function rho small gtpase ph-dependent binding vav regulates activation mer tyrosine kinase sheets ed tension-dependent binding fcgamma-receptors induce mac-1 human mononuclear phagocytes related subjects distinct migration behaviours small guanosine triphosphatases cd45 segregation west ap jr dynamic macrophage “probing” protein/plasma membrane association dynamic cortical actin ligand-independent tonic signaling privacy choices/manage cookies macrophage integrin alphambeta2 cell surface cd44 actin cytoskeleton reorganization stossel tp conserved phosphotyrosyl residues listeria-induced phagocytosis fcgamma receptor signalling rapid hop diffusion

Schema {🗺️}

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         headline:Picket-fences in the plasma membrane: functions in immune cells and phagocytosis
         description:Recent studies of molecular mobility in the plasma membrane have revealed that diffusion is restricted by cytoskeletal networks or fences. Transmembrane protein “pickets” that reversibly associate with the membrane-associated skeleton and with the pericellular coat impede the movement of unattached bystander molecules. While membrane picket-fences were originally described as barriers to free diffusion in more passive cell types such as fibroblasts, they have particularly important functions in the more dynamic immune cells. In phagocytes, such fences curtail spontaneous activation and their disassembly facilitates stimulation by target particles, fostering receptor clustering and the exclusion of phosphatases from the phagocytic cup. In this review, we describe the nature of the cellular cytoskeleton and of the exoskeleton created by the pericellular coat, their association with transmembrane pickets, and the modulation of molecular mobility during phagocytosis.
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            Spectrin
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            CD44
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      headline:Picket-fences in the plasma membrane: functions in immune cells and phagocytosis
      description:Recent studies of molecular mobility in the plasma membrane have revealed that diffusion is restricted by cytoskeletal networks or fences. Transmembrane protein “pickets” that reversibly associate with the membrane-associated skeleton and with the pericellular coat impede the movement of unattached bystander molecules. While membrane picket-fences were originally described as barriers to free diffusion in more passive cell types such as fibroblasts, they have particularly important functions in the more dynamic immune cells. In phagocytes, such fences curtail spontaneous activation and their disassembly facilitates stimulation by target particles, fostering receptor clustering and the exclusion of phosphatases from the phagocytic cup. In this review, we describe the nature of the cellular cytoskeleton and of the exoskeleton created by the pericellular coat, their association with transmembrane pickets, and the modulation of molecular mobility during phagocytosis.
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         Macrophage
         Cytoskeleton
         F-actin
         Spectrin
         Glycocalyx
         Single-particle tracking
         Diffusion
         CD44
         CD45
         Immunology
         Internal Medicine
         Pathology
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