We are analyzing https://link.springer.com/article/10.1007/s00281-013-0384-6.

Title:
Molecular mechanisms regulating NETosis in infection and disease | Seminars in Immunopathology
Description:
Neutrophils are the foot soldiers of the immune system. They home in to the site of infection and kill pathogens by phagocytosis, degranulation, and the release of web-like structures called neutrophil extracellular traps (NETs) that trap and kill a variety of microbes. NETs have been shown to play a multitude of additional roles in immunity but have also been implicated in inflammatory and autoimmune disease. Here, we discuss the role of NETs in these various contexts with a particular emphasis on the molecular mechanisms that regulate NET release and clearance. We highlight the comprehensive concepts and explore the important open questions in the field.
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Keywords {🔍}

nets, net, google, scholar, neutrophil, neutrophils, pubmed, cas, formation, release, extracellular, netosis, infection, patients, cells, traps, role, cell, killing, disease, induce, important, mice, immune, antimicrobial, systemic, immunol, shown, chromatin, activation, infections, human, mpo, activity, ros, studies, proteins, defense, form, lupus, mechanisms, microbes, response, fungal, pad, sle, protein, mechanism, cgd, deficient,

Topics {✒️}

human immunodeficiency virus human immunodeficiency virus-1 neutrophil elastase-mediated degradation bayer-technicon automated hematology deep vein thrombosis mouse mrl/ltr model coli-induced netosis stems transforming growth factor-β systemic lupus erythematosus anti-histone antibodies abrogate cell death-mediated pathway chronic granulomatous disease cell-activating factor baff anti-pad4 neutralizing antibodies beta-hydroxybutyrate abrogates formation foe—netting neutrophils immobilize gram-negative bacterial pneumonia neutrophil-mediated platelet activation raf-mek-erk pathway neutrophil-specific protease escapes anti-neutrophil cytoplasmic antibodies plasmodium falciparum-infected children net-mediated thrombus formation guimaraes-costa ab tgf-β inhibition resulted impairing thrombomodulin-dependent protein article download pdf pinto-da-silva lh dnase i-deficient mice wild-type mouse serum mpo-deficient individuals illustrates netosis-mediated cell death short-ranged antimicrobial proteins human blood-derived neutrophils completely mpo-deficient individuals myeloid-related protein-14 contributes cell-helper neutrophils stimulate completely mpo-deficient patients von kockritz-blickwede tnf-α-induced nets low-density granulocyte subset von willebrand factor feline leukemia virus inhibiting tgf-β leads pore-forming virulence factors major antimicrobial phagocytes important anti-inflammatory strategy venizelos papayannopoulos reduced lesion size neutrophil extracellular traps

Questions {❓}

Do NETs kill?
Gupta A, Hasler P, Gebhardt S, Holzgreve W, Hahn S (2006) Occurrence of neutrophil extracellular DNA traps (NETs) in pre-eclampsia: a link with elevated levels of cell-free DNA?
Gupta AK, Hasler P, Holzgreve W, Hahn S (2007) Neutrophil NETs: a novel contributor to preeclampsia-associated placental hypoxia?
Menegazzi R, Decleva E, Dri P (2012) Killing by neutrophil extracellular traps: fact or folklore?
Urban CF, Lourido S, Zychlinsky A (2006) How do microbes evade neutrophil killing?

Schema {🗺️}

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         description:Neutrophils are the foot soldiers of the immune system. They home in to the site of infection and kill pathogens by phagocytosis, degranulation, and the release of web-like structures called neutrophil extracellular traps (NETs) that trap and kill a variety of microbes. NETs have been shown to play a multitude of additional roles in immunity but have also been implicated in inflammatory and autoimmune disease. Here, we discuss the role of NETs in these various contexts with a particular emphasis on the molecular mechanisms that regulate NET release and clearance. We highlight the comprehensive concepts and explore the important open questions in the field.
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            Neutrophil Elastase
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            Internal Medicine
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      headline:Molecular mechanisms regulating NETosis in infection and disease
      description:Neutrophils are the foot soldiers of the immune system. They home in to the site of infection and kill pathogens by phagocytosis, degranulation, and the release of web-like structures called neutrophil extracellular traps (NETs) that trap and kill a variety of microbes. NETs have been shown to play a multitude of additional roles in immunity but have also been implicated in inflammatory and autoimmune disease. Here, we discuss the role of NETs in these various contexts with a particular emphasis on the molecular mechanisms that regulate NET release and clearance. We highlight the comprehensive concepts and explore the important open questions in the field.
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         Human Immunodeficiency Virus
         Systemic Lupus Erythematosus
         Systemic Lupus Erythematosus Patient
         Chronic Granulomatous Disease
         Neutrophil Elastase
         Immunology
         Internal Medicine
         Pathology
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