We are analyzing https://link.springer.com/article/10.1007/s00281-006-0023-6.

Title:
Regulatory T cells in pregnancy | Seminars in Immunopathology
Description:
Tolerance mechanisms are responsible for the survival of the fetus within the maternal uterus without being attacked by the cells of the maternal immune system despite their direct contact. Regulatory T cells (Treg) were claimed to be important players in the tolerance towards the fetus bearing alloantigens. Recent evidence confirmed an augmentation in the number of Treg during pregnancy and, most importantly, diminished numbers of Treg were associated with immunological rejection of the fetus. This could be prevented by adoptively transferring CD4+/CD25+ Treg cells from normal pregnant mice into abortion-prone animals. Treg prevented abortion while creating a transient tolerant microenvironment characterized by high levels of TGF-β, LIF, and HO-1. Downregulated levels of Treg were accordingly also reported during human miscarriage. Furthermore, we have evidence suggesting that, to be protective, Treg need to be activated by male antigens during pregnancy.
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Keywords {🔍}

google, scholar, article, pubmed, cas, immunol, cells, zenclussen, regulatory, pregnancy, tolerance, reprod, maternal, abortion, cdcd, cell, volk, mice, immune, treg, fetal, murine, interface, implantation, spontaneous, sollwedel, bertoja, gerlof, springer, levels, human, access, transplantation, nat, expression, smith, privacy, cookies, content, fetus, normal, male, transfer, receptor, peripheral, mellor, heme, zambon, function, publish,

Topics {✒️}

alloantigen-induced cd25+cd4+ regulatory month download article/chapter ana claudia zenclussen pregnancy-induced cd4+cd25+ foxp3-mediated immune suppression maternal immune system substance p-dependent alteration innate immune system article springer seminars early-onset pre-eclampsia mhc-incompatible cardiac allografts rescue abortion-prone fetuses cell-driven complement activation abortion-prone mice promotes early pregnancy subjects interleukin-12-mediated murine abortion decidual p-selection expression stress-induced murine abortion full article pdf normal human pregnancy regulatory cd4+cd25+ cd25+cd4+ regulatory cd4+cd25+ regulatory early maternal tolerance cd25−cd4+ precursors auto-immune diseases kupiec-weglinski jw privacy choices/manage cookies estrogen-treated mice cytokines/placenta/spleen/serum unexplained recurrent abortions pregnancy-induced unresponsiveness male factor signaling male skin grafts t-lymphocyte population cd4+cd25− cells cd4+cd103+ regulatory normal pregnant mice tgf-beta signaling organ allograft recipients paternal white cells maria laura zenclussen receptor-4 null mutation article zenclussen related subjects female reproductive tract privileged tolerant microenvironment maternal–fetal tolerance fetal growth restriction maternal uterine decidua

Questions {❓}

Tan XW, Liao H, Sun L, Okabe M, Xiao ZC, Dawe GS (2005) Fetal microchimerism in the maternal mouse brain: a novel population of fetal progenitor or stem cells able to cross the blood–brain barrier?

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