We are analyzing https://link.springer.com/article/10.1007/s00281-004-0176-0.

Title:
Pathways for antigen cross presentation | Seminars in Immunopathology
Description:
Dendritic cells (DCs) have the unique ability to capture cellular tissue antigens, and to present them on MHC class I molecules to antigen-specific CD8+ T lymphocytes after migration to the draining lymph nodes. This process, called “cross presentation” can lead either to the tolerization or activation of antigen-specific CD8+ T cells. Antigen capture is believed to occur by phagocytosis of antigen-bearing dead cells. Recent studies suggest that the antigen transferred from the phagocytosed cell to the DC during cross presentation is a proteasome substrate, rather than a proteasomal degradation product. In most cases, the formation of the peptide-MHC class I complexes in DCs requires the export of protein antigens from phagosomes to the cytosol, where they undergo proteasomal degradation. The resulting peptides are then translocated by TAP to the lumen of a cross presentation-loading compartment, for association to MHC class I under the control of chaperones and oxido-reductases. This loading compartment may be either the endoplasmic reticulum (ER) or a mix phagosome-ER compartment. MHC class I egress from the loading compartment to cell surface remains to be analyzed.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

google, scholar, cells, dendritic, class, cell, immunol, antigens, antigen, mhc, presentation, crosspresentation, med, exp, nature, article, protein, molecules, immunity, exogenous, usa, science, cross, endoplasmic, crosspriming, proc, natl, acad, sci, proteins, vivo, eur, biol, membrane, processing, cellular, proteasome, compartment, cytotoxic, rev, complex, maturation, content, springer, reticulum, nat, major, histocompatibility, irestricted, apoptotic,

Topics {✒️}

h-2dd pre-mrnas results class i-restricted cross-presentation month download article/chapter pa28alpha/beta proteasome regulator bone marrow-derived cells major histocompatibility complex mfg-e8-deficient mice aaa atpase cdc48/p97 antigen-bearing dead cells expand tumor-reactive cd8 epstein-barr virus-transformed bacteria-induced neo-biosynthesis dendritic cell-derived exosomes rapidly cross-present antigen dendritic cell cross-presentation retrograde protein translocation fcgamma receptor-mediated induction bevan mj vaccinia virus-derived antigens major histocompatibility antigens vaccinia virus-specific cd8 immune complex internalization article springer seminars er-phagosome fusion defines cross presentation-loading compartment tumor-derived exosomes mix phagosome-er compartment bacterial fusion protein presenting cells immature dendritic cells t-cell responses privacy choices/manage cookies dendritic cell responses cytotoxic t-cell immunity human dendritic cells antigen cross-presentation antigen cross presentation phagocytic antigen processing early antigen presentation sebastian amigorena h-2 congenic cells antigen-specific cd8+ cloned dendritic cells mouse dendritic cells developing dendritic cells dendritic cells form peptide-mhc class cytomegalovirus proteins us2 retro-translocation full article pdf

Questions {❓}

Zinkernagel RM (2002) On cross-priming of MHC class I-specific CTL: rule or exception?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Pathways for antigen cross presentation
         description:Dendritic cells (DCs) have the unique ability to capture cellular tissue antigens, and to present them on MHC class I molecules to antigen-specific CD8+ T lymphocytes after migration to the draining lymph nodes. This process, called “cross presentation” can lead either to the tolerization or activation of antigen-specific CD8+ T cells. Antigen capture is believed to occur by phagocytosis of antigen-bearing dead cells. Recent studies suggest that the antigen transferred from the phagocytosed cell to the DC during cross presentation is a proteasome substrate, rather than a proteasomal degradation product. In most cases, the formation of the peptide-MHC class I complexes in DCs requires the export of protein antigens from phagosomes to the cytosol, where they undergo proteasomal degradation. The resulting peptides are then translocated by TAP to the lumen of a cross presentation-loading compartment, for association to MHC class I under the control of chaperones and oxido-reductases. This loading compartment may be either the endoplasmic reticulum (ER) or a mix phagosome-ER compartment. MHC class I egress from the loading compartment to cell surface remains to be analyzed.
         datePublished:2004-12-03T00:00:00Z
         dateModified:2004-12-03T00:00:00Z
         pageStart:257
         pageEnd:271
         sameAs:https://doi.org/10.1007/s00281-004-0176-0
         keywords:
            Dendritic cells
            Cross presentation
            MHC class I
            Phagosomes
            Proteasome
            Immunology
            Internal Medicine
            Pathology
         image:
         isPartOf:
            name:Springer Seminars in Immunopathology
            issn:
               1432-2196
               0344-4325
            volumeNumber:26
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Pierre Guermonprez
               affiliation:
                     name:Institut Curie
                     address:
                        name:U365 INSERM, Institut Curie, Paris, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sebastian Amigorena
               affiliation:
                     name:Institut Curie
                     address:
                        name:U365 INSERM, Institut Curie, Paris, France
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Pathways for antigen cross presentation
      description:Dendritic cells (DCs) have the unique ability to capture cellular tissue antigens, and to present them on MHC class I molecules to antigen-specific CD8+ T lymphocytes after migration to the draining lymph nodes. This process, called “cross presentation” can lead either to the tolerization or activation of antigen-specific CD8+ T cells. Antigen capture is believed to occur by phagocytosis of antigen-bearing dead cells. Recent studies suggest that the antigen transferred from the phagocytosed cell to the DC during cross presentation is a proteasome substrate, rather than a proteasomal degradation product. In most cases, the formation of the peptide-MHC class I complexes in DCs requires the export of protein antigens from phagosomes to the cytosol, where they undergo proteasomal degradation. The resulting peptides are then translocated by TAP to the lumen of a cross presentation-loading compartment, for association to MHC class I under the control of chaperones and oxido-reductases. This loading compartment may be either the endoplasmic reticulum (ER) or a mix phagosome-ER compartment. MHC class I egress from the loading compartment to cell surface remains to be analyzed.
      datePublished:2004-12-03T00:00:00Z
      dateModified:2004-12-03T00:00:00Z
      pageStart:257
      pageEnd:271
      sameAs:https://doi.org/10.1007/s00281-004-0176-0
      keywords:
         Dendritic cells
         Cross presentation
         MHC class I
         Phagosomes
         Proteasome
         Immunology
         Internal Medicine
         Pathology
      image:
      isPartOf:
         name:Springer Seminars in Immunopathology
         issn:
            1432-2196
            0344-4325
         volumeNumber:26
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Pierre Guermonprez
            affiliation:
                  name:Institut Curie
                  address:
                     name:U365 INSERM, Institut Curie, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sebastian Amigorena
            affiliation:
                  name:Institut Curie
                  address:
                     name:U365 INSERM, Institut Curie, Paris, France
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Springer Seminars in Immunopathology
      issn:
         1432-2196
         0344-4325
      volumeNumber:26
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Institut Curie
      address:
         name:U365 INSERM, Institut Curie, Paris, France
         type:PostalAddress
      name:Institut Curie
      address:
         name:U365 INSERM, Institut Curie, Paris, France
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Pierre Guermonprez
      affiliation:
            name:Institut Curie
            address:
               name:U365 INSERM, Institut Curie, Paris, France
               type:PostalAddress
            type:Organization
      name:Sebastian Amigorena
      affiliation:
            name:Institut Curie
            address:
               name:U365 INSERM, Institut Curie, Paris, France
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:U365 INSERM, Institut Curie, Paris, France
      name:U365 INSERM, Institut Curie, Paris, France
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(121)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.05s.

LINK . SPRINGER . COM {}