We are analyzing https://link.springer.com/article/10.1007/s00280-011-1700-2.

Title:
Oxidative damage to guanine nucleosides following combination chemotherapy with 5-fluorouracil and oxaliplatin | Cancer Chemotherapy and Pharmacology
Description:
Recent in vitro and animal studies have suggested that the cytotoxicity of 5-fluorouracil and oxaliplatin is linked to increased formation of reactive oxygen species (ROS). This prospective study was undertaken to examine the generation of oxidative stress, in 106 colorectal cancer patients, by 5-fluorouracil and oxaliplatin combination (FOLFOX) therapy as measured by urinary excretion of 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydro-guanosine (8-oxoGuo). The amounts of 8-oxoGuo and 8-oxodG were measured in 3 spot urine samples from 106 patients by using ultra performance liquid chromatography and tandem mass spectrometry. Furthermore, we collected information on other clinical and demographic variables hypothesized to be associated with oxidative stress. Repeated measures linear mixed models were used to model the relationship between urinary concentrations of 8-oxoGuo and 8-oxodG and the treatment effect and the other variables. The analysis showed that chemotherapy increased the excretion of 8-oxoGuo and 8-oxodG around 15% (P < 0.0001 and P = 0.02, respectively) though there was a significant interaction with CRP levels. Additionally, we found that sex, smoking status, age, and c-reactive protein were related to urinary excretion of 8-oxoGuo and 8-oxodG in colorectal cancer patients. These results indicate that FOLFOX induces ROS in patients and that ROS-generating mechanisms interact.
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article, google, scholar, pubmed, cas, cancer, oxidative, human, cell, res, cells, biol, chemotherapy, oxaliplatin, poulsen, dna, damage, oxygen, patients, fluorouracil, weimann, reactive, stress, oxodg, oxoguo, urine, access, apoptosis, med, production, free, privacy, cookies, content, analysis, afzal, species, colorectal, urinary, growth, hydrogen, peroxide, radic, copenhagen, information, publish, search, pharmacology, june, shoaib,

Topics {✒️}

month download article/chapter base excision repair sodium salicylate-induced apoptosis søren astrup jensen jens benn sørensen c-reactive protein tandem mass spectrometry granulocyte-derived hydrogen peroxide oxidative stress-induced apoptosis ros-generating mechanisms interact ultraperformance liquid chromatography full article pdf 8-dihydro-8-oxo-2’-deoxyguanosine inhibits article cancer chemotherapy privacy choices/manage cookies related subjects ferredoxin reductase gene reactive oxygen species colorectal cancer cells 8-dihydro-guanosine access oxygen free radicals colon carcinoma cells controlling tumor growth human tumor cells mouse osteoblastic cells cd34 + myelodysplastic cells age-dependent increases article afzal persistent oxidative stress hepg2 hepatocellular carcinoma human skeletal muscle 5-fluorouracil-induced apoptosis programmed cell death folfox induces ros colorectal cancer patients european economic area 8-iso-prostaglandin f2α chung ym h2o2-induced senescent normal human fibroblasts ib4-positive nociceptors antioxidative enzyme expression mammalian cell proliferation conditions privacy policy modulating endogenous production oxidative dna damage t-cell function dna oxidation simultaneously accepting optional cookies enhanced ros production

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         headline:Oxidative damage to guanine nucleosides following combination chemotherapy with 5-fluorouracil and oxaliplatin
         description:Recent in vitro and animal studies have suggested that the cytotoxicity of 5-fluorouracil and oxaliplatin is linked to increased formation of reactive oxygen species (ROS). This prospective study was undertaken to examine the generation of oxidative stress, in 106 colorectal cancer patients, by 5-fluorouracil and oxaliplatin combination (FOLFOX) therapy as measured by urinary excretion of 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydro-guanosine (8-oxoGuo). The amounts of 8-oxoGuo and 8-oxodG were measured in 3 spot urine samples from 106 patients by using ultra performance liquid chromatography and tandem mass spectrometry. Furthermore, we collected information on other clinical and demographic variables hypothesized to be associated with oxidative stress. Repeated measures linear mixed models were used to model the relationship between urinary concentrations of 8-oxoGuo and 8-oxodG and the treatment effect and the other variables. The analysis showed that chemotherapy increased the excretion of 8-oxoGuo and 8-oxodG around 15% (P < 0.0001 and P = 0.02, respectively) though there was a significant interaction with CRP levels. Additionally, we found that sex, smoking status, age, and c-reactive protein were related to urinary excretion of 8-oxoGuo and 8-oxodG in colorectal cancer patients. These results indicate that FOLFOX induces ROS in patients and that ROS-generating mechanisms interact.
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      headline:Oxidative damage to guanine nucleosides following combination chemotherapy with 5-fluorouracil and oxaliplatin
      description:Recent in vitro and animal studies have suggested that the cytotoxicity of 5-fluorouracil and oxaliplatin is linked to increased formation of reactive oxygen species (ROS). This prospective study was undertaken to examine the generation of oxidative stress, in 106 colorectal cancer patients, by 5-fluorouracil and oxaliplatin combination (FOLFOX) therapy as measured by urinary excretion of 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydro-guanosine (8-oxoGuo). The amounts of 8-oxoGuo and 8-oxodG were measured in 3 spot urine samples from 106 patients by using ultra performance liquid chromatography and tandem mass spectrometry. Furthermore, we collected information on other clinical and demographic variables hypothesized to be associated with oxidative stress. Repeated measures linear mixed models were used to model the relationship between urinary concentrations of 8-oxoGuo and 8-oxodG and the treatment effect and the other variables. The analysis showed that chemotherapy increased the excretion of 8-oxoGuo and 8-oxodG around 15% (P < 0.0001 and P = 0.02, respectively) though there was a significant interaction with CRP levels. Additionally, we found that sex, smoking status, age, and c-reactive protein were related to urinary excretion of 8-oxoGuo and 8-oxodG in colorectal cancer patients. These results indicate that FOLFOX induces ROS in patients and that ROS-generating mechanisms interact.
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