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month download article/chapter high-risk endometrial cancer high-risk stage iii high-grade epithelial cancers article cancer chemotherapy high-risk endometrial carcinoma surgical-pathological risk factors article egawa-takata completely resected cases iv endometrial cancer recurrent endometrial cancer advanced endometrial cancer primary peritoneal cancer refractory ovarian cancer takayuki enomoto privacy choices/manage cookies gynecologic oncology group 2-23 rinku orai-kita full article pdf remission-induction therapy cancer clinical trials chemotherapy naïve women operative oncology group adjuvant tec therapy adjuvant radiation therapy recurrent endometrial carcinomas masato yamasaki masaaki nagamatsu gogo-em1 study phase iii trial recurrent endometrial carcinoma /ii prospective study advanced endometrial carcinoma dose escalation methods ken-ichirou morishige tadashi kimura masahiro asada 1179-3 kita-kunagasone-cho phase ii study divided-dose paclitaxel advanced epithelial ovarian conditions privacy policy phase ii trial occasional severe toxicity epirubicin 50 mg/m2 retrospective comparison showed effective remission-induction paclitaxel 150 mg/m2 advanced primary disease accepting optional cookies

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         headline:Chemotherapy for endometrial carcinoma (GOGO-EM1 study): TEC (paclitaxel, epirubicin, and carboplatin) is an effective remission-induction and adjuvant therapy
         description:TAP chemotherapy (paclitaxel, doxorubicin, and cisplatin) is effective for advanced and recurrent endometrial carcinoma, but has occasional severe toxicity. TEC chemotherapy (paclitaxel, epirubicin, and carboplatin) has been suggested to have less toxicity; however, the optimal dosage has yet to be determined. Phase I/II prospective study for TEC therapy was performed. A retrospective comparison of the prognosis between adjuvant TEC therapy and radiation for completely resected cases with risk factors was also performed. The recommended dose of TEC therapy was determined to be paclitaxel 150 mg/m2, epirubicin 50 mg/m2, and carboplatin AUC 4. A TEC regimen at this dose level was shown to be tolerable. The response rate and median overall survival were 74% and 37 months for those with advanced primary disease (Group B) and 50% and 26 months for recurrent tumors (Group C), respectively. A retrospective comparison showed that adjuvant TEC therapy for completely resected stage III cases improved their prognosis when compared to an adjuvant radiation therapy. TEC therapy was demonstrated to be a tolerable and effective treatment, not only as a remission-induction therapy for advanced and recurrent endometrial carcinomas but also as the adjuvant therapy.
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      name:Yutaka Ueda
      affiliation:
            name:Osaka University Graduate School of Medicine
            address:
               name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Chie Kuragaki
      affiliation:
            name:Osaka University Graduate School of Medicine
            address:
               name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Takahito Miyake
      affiliation:
            name:Osaka University Graduate School of Medicine
            address:
               name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
               type:PostalAddress
            type:Organization
            name:Osaka Rosai Hospital
            address:
               name:Osaka Rosai Hospital, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Takashi Miyatake
      affiliation:
            name:Osaka University Graduate School of Medicine
            address:
               name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Masami Fujita
      affiliation:
            name:Osaka University Graduate School of Medicine
            address:
               name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Kiyoshi Yoshino
      affiliation:
            name:Osaka University Graduate School of Medicine
            address:
               name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Ryuichi Nakashima
      affiliation:
            name:Osaka University Graduate School of Medicine
            address:
               name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Mika Okazawa
      affiliation:
            name:Osaka University Graduate School of Medicine
            address:
               name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
               type:PostalAddress
            type:Organization
            name:Kaizuka City Hospital
            address:
               name:Kaizuka City Hospital, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Tateki Tsutsui
      affiliation:
            name:Osaka University Graduate School of Medicine
            address:
               name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Ken-Ichirou Morishige
      affiliation:
            name:Osaka University Graduate School of Medicine
            address:
               name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Tadashi Kimura
      affiliation:
            name:Osaka University Graduate School of Medicine
            address:
               name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Masato Yamasaki
      affiliation:
            name:Osaka Rosai Hospital
            address:
               name:Osaka Rosai Hospital, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Takamichi Nishizaki
      affiliation:
            name:Suita Municipal Hospital
            address:
               name:Suita Municipal Hospital, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Masaaki Nagamatsu
      affiliation:
            name:Kaizuka City Hospital
            address:
               name:Kaizuka City Hospital, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Kimihiko Ito
      affiliation:
            name:Kansai Rosai Hospital
            address:
               name:Kansai Rosai Hospital, Hyogo, Japan
               type:PostalAddress
            type:Organization
      name:Masahiro Asada
      affiliation:
            name:Itami City Hospital
            address:
               name:Itami City Hospital, Hyogo, Japan
               type:PostalAddress
            type:Organization
      name:Kazuhide Ogita
      affiliation:
            name:Rinku General Medical Center
            address:
               name:Rinku General Medical Center, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Akinori Wakimoto
      affiliation:
            name:Osaka Koseinenkin Hospital
            address:
               name:Osaka Koseinenkin Hospital, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Toshiya Yamamoto
      affiliation:
            name:Sakai Municipal Hospital
            address:
               name:Sakai Municipal Hospital, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Yukihiro Nishio
      affiliation:
            name:Osaka Police Hospital
            address:
               name:Osaka Police Hospital, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Takayuki Enomoto
      affiliation:
            name:Osaka University Graduate School of Medicine
            address:
               name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Osaka Rosai Hospital, Osaka, Japan
      name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Kaizuka City Hospital, Osaka, Japan
      name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
      name:Osaka Rosai Hospital, Osaka, Japan
      name:Suita Municipal Hospital, Osaka, Japan
      name:Kaizuka City Hospital, Osaka, Japan
      name:Kansai Rosai Hospital, Hyogo, Japan
      name:Itami City Hospital, Hyogo, Japan
      name:Rinku General Medical Center, Osaka, Japan
      name:Osaka Koseinenkin Hospital, Osaka, Japan
      name:Sakai Municipal Hospital, Osaka, Japan
      name:Osaka Police Hospital, Osaka, Japan
      name:Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
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