
LINK . SPRINGER . COM {
}
Title:
Mechanistic population pharmacokinetics of total and unbound paclitaxel for a new nanodroplet formulation versus Taxol in cancer patients | Cancer Chemotherapy and Pharmacology
Description:
Our objectives were (1) to compare the disposition and in vivo release of paclitaxel between a tocopherol-based Cremophor-free formulation (Tocosol Paclitaxel®) and Cremophor® EL-formulated paclitaxel (Taxol®) in human subjects, and (2) to develop a mechanistic model for unbound and total paclitaxel pharmacokinetics. A total of 35 patients (average ± SD age: 59 ±13 years) with advanced non-hematological malignancies were studied in a randomized two-way crossover trial. Patients received 175 mg/m2 paclitaxel as 15 min (Tocosol Paclitaxel) or 3 h (Taxol) intravenous infusion in each study period. Paclitaxel concentrations were determined by LC–MS/MS in plasma ultrafiltrate and whole blood. NONMEM VI was used for population pharmacokinetics. A linear disposition model with three compartments for unbound paclitaxel and a one-compartment model for Cremophor were applied. Total clearance of unbound paclitaxel was 845 L/h (variability: 25% CV). The prolonged release with Tocosol Paclitaxel was explained by the limited solubility of unbound paclitaxel of 405 ng/mL (estimated) in plasma. The 15 min Tocosol Paclitaxel infusion yielded a mean time to 90% cumulative input of 1.14 ± 0.16 h. Tocosol Paclitaxel was estimated to release 9.8% of the dose directly into the deep peripheral compartment. The model accounted for the presence of drug-containing nanodroplets in blood. Population pharmacokinetic analysis indicated linear disposition and a potentially higher bioavailability of unbound paclitaxel following Tocosol Paclitaxel administration due to direct release at the target site. The prolonged release of Tocosol Paclitaxel supports 15 min paclitaxel infusions. This mechanistic model may be important for development of prolonged release formulations that distribute in and from the systemic circulation.
Website Age:
28 years and 1 months (reg. 1997-05-29).
Matching Content Categories {📚}
- Education
- Health & Fitness
- Cryptocurrency
Content Management System {📝}
What CMS is link.springer.com built with?
Custom-built
No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of link.springer.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 7,734,772 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Link.springer.com Make Money? {💸}
We can't tell how the site generates income.
Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.
Keywords {🔍}
paclitaxel, cdot, google, scholar, pubmed, cas, article, cancer, pharmacokinetics, drug, layer, clin, unbound, tocosol, sparreboom, van, taxol, plasma, ctextsol, atextnano, sample, release, cremophor, nanodroplets, population, verweij, oncol, textbftexttoc, patients, study, blood, pharmacol, res, left, model, pharmacokinetic, unstirred, water, nanodroplet, formulation, disposition, compartment, clinical, textka, ttextproc, vtextnano, mechanistic, total, volume, human,
Topics {✒️}
{\frac{{{\text{ka}} \cdot \left cdot a_{\text{nano}} $$ cdot a_{\text{nano}} }} }}a_{\text{nano}} }}{{{\text{ }}a_{\text{layer}} }}{{{\text{ }_{\text{nano}} $$ {1 - \frac{{a_{{{\text{blood}} { 1- \frac{{a_{\text{blood = \frac{{a_{\text{blood }}a_{{{\text{nano}} $$ \begin{aligned} \frac{{{\text{ }}a_{\text{blood $$ a_{\text{blood $$ \frac{{{\text{ {t_{\text{proc}} } }}}} \cdot \left }} \cdot \left $$ {\text{cu}}\left cdot {\rm order input da nano/dt 90% cumulative input c1 sol ka input {\text{ }}}} }}{{{\text{ }} }}{{{\text{ month download article/chapter differential da layer/dt tocopherol-based cremophor-free formulation nano nano· n1 rapid esterase-sensitive breakdown article cancer chemotherapy unstirred water layer colorimetric dye-binding microassay tocosol paclitaxel compared hematological malignancies mechanism-based pharmacokinetic model cremophor el-mediated alteration tocosol paclitaxel nanodroplets nonlinear mixed-effect modelling cremophor® el-formulated paclitaxel solubility-limited transfer full article pdf nonmem users guides n2
Schema {🗺️}
WebPage:
mainEntity:
headline:Mechanistic population pharmacokinetics of total and unbound paclitaxel for a new nanodroplet formulation versus Taxol in cancer patients
description:Our objectives were (1) to compare the disposition and in vivo release of paclitaxel between a tocopherol-based Cremophor-free formulation (Tocosol Paclitaxel®) and Cremophor® EL-formulated paclitaxel (Taxol®) in human subjects, and (2) to develop a mechanistic model for unbound and total paclitaxel pharmacokinetics. A total of 35 patients (average ± SD age: 59 ±13 years) with advanced non-hematological malignancies were studied in a randomized two-way crossover trial. Patients received 175 mg/m2 paclitaxel as 15 min (Tocosol Paclitaxel) or 3 h (Taxol) intravenous infusion in each study period. Paclitaxel concentrations were determined by LC–MS/MS in plasma ultrafiltrate and whole blood. NONMEM VI was used for population pharmacokinetics. A linear disposition model with three compartments for unbound paclitaxel and a one-compartment model for Cremophor were applied. Total clearance of unbound paclitaxel was 845 L/h (variability: 25% CV). The prolonged release with Tocosol Paclitaxel was explained by the limited solubility of unbound paclitaxel of 405 ng/mL (estimated) in plasma. The 15 min Tocosol Paclitaxel infusion yielded a mean time to 90% cumulative input of 1.14 ± 0.16 h. Tocosol Paclitaxel was estimated to release 9.8% of the dose directly into the deep peripheral compartment. The model accounted for the presence of drug-containing nanodroplets in blood. Population pharmacokinetic analysis indicated linear disposition and a potentially higher bioavailability of unbound paclitaxel following Tocosol Paclitaxel administration due to direct release at the target site. The prolonged release of Tocosol Paclitaxel supports 15 min paclitaxel infusions. This mechanistic model may be important for development of prolonged release formulations that distribute in and from the systemic circulation.
datePublished:2008-09-13T00:00:00Z
dateModified:2008-09-13T00:00:00Z
pageStart:1049
pageEnd:1063
sameAs:https://doi.org/10.1007/s00280-008-0827-2
keywords:
Paclitaxel
Ultrafiltration
Non-hematological malignancies
Mechanistic modeling
Population pharmacokinetics
NONMEM
Solubility limited disposition model
Oncology
Pharmacology/Toxicology
Cancer Research
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00280-008-0827-2/MediaObjects/280_2008_827_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00280-008-0827-2/MediaObjects/280_2008_827_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00280-008-0827-2/MediaObjects/280_2008_827_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00280-008-0827-2/MediaObjects/280_2008_827_Fig4_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00280-008-0827-2/MediaObjects/280_2008_827_Fig5_HTML.gif
isPartOf:
name:Cancer Chemotherapy and Pharmacology
issn:
1432-0843
0344-5704
volumeNumber:63
type:
Periodical
PublicationVolume
publisher:
name:Springer-Verlag
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Jürgen B. Bulitta
affiliation:
name:University at Buffalo, State University of New York
address:
name:Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, USA
type:PostalAddress
type:Organization
type:Person
name:Ping Zhao
affiliation:
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
type:Organization
type:Person
name:Robert D. Arnold
affiliation:
name:University at Buffalo, State University of New York
address:
name:Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, USA
type:PostalAddress
type:Organization
name:University of Georgia
address:
name:Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, USA
type:PostalAddress
type:Organization
type:Person
name:Dean R. Kessler
affiliation:
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
type:Organization
type:Person
name:Richard Daifuku
affiliation:
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
type:Organization
type:Person
name:James Pratt
affiliation:
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
type:Organization
type:Person
name:Gabriel Luciano
affiliation:
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
type:Organization
type:Person
name:Axel-R Hanauske
affiliation:
name:St. Georg Hospital
address:
name:Department of Medical Oncology, St. Georg Hospital, Hamburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Hans Gelderblom
affiliation:
name:Leiden University Medical Center
address:
name:Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
type:PostalAddress
type:Organization
type:Person
name:Ahmad Awada
affiliation:
name:Institut Jules Bordet
address:
name:Institut Jules Bordet, Brussels, Belgium
type:PostalAddress
type:Organization
type:Person
name:William J. Jusko
affiliation:
name:University at Buffalo, State University of New York
address:
name:Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Mechanistic population pharmacokinetics of total and unbound paclitaxel for a new nanodroplet formulation versus Taxol in cancer patients
description:Our objectives were (1) to compare the disposition and in vivo release of paclitaxel between a tocopherol-based Cremophor-free formulation (Tocosol Paclitaxel®) and Cremophor® EL-formulated paclitaxel (Taxol®) in human subjects, and (2) to develop a mechanistic model for unbound and total paclitaxel pharmacokinetics. A total of 35 patients (average ± SD age: 59 ±13 years) with advanced non-hematological malignancies were studied in a randomized two-way crossover trial. Patients received 175 mg/m2 paclitaxel as 15 min (Tocosol Paclitaxel) or 3 h (Taxol) intravenous infusion in each study period. Paclitaxel concentrations were determined by LC–MS/MS in plasma ultrafiltrate and whole blood. NONMEM VI was used for population pharmacokinetics. A linear disposition model with three compartments for unbound paclitaxel and a one-compartment model for Cremophor were applied. Total clearance of unbound paclitaxel was 845 L/h (variability: 25% CV). The prolonged release with Tocosol Paclitaxel was explained by the limited solubility of unbound paclitaxel of 405 ng/mL (estimated) in plasma. The 15 min Tocosol Paclitaxel infusion yielded a mean time to 90% cumulative input of 1.14 ± 0.16 h. Tocosol Paclitaxel was estimated to release 9.8% of the dose directly into the deep peripheral compartment. The model accounted for the presence of drug-containing nanodroplets in blood. Population pharmacokinetic analysis indicated linear disposition and a potentially higher bioavailability of unbound paclitaxel following Tocosol Paclitaxel administration due to direct release at the target site. The prolonged release of Tocosol Paclitaxel supports 15 min paclitaxel infusions. This mechanistic model may be important for development of prolonged release formulations that distribute in and from the systemic circulation.
datePublished:2008-09-13T00:00:00Z
dateModified:2008-09-13T00:00:00Z
pageStart:1049
pageEnd:1063
sameAs:https://doi.org/10.1007/s00280-008-0827-2
keywords:
Paclitaxel
Ultrafiltration
Non-hematological malignancies
Mechanistic modeling
Population pharmacokinetics
NONMEM
Solubility limited disposition model
Oncology
Pharmacology/Toxicology
Cancer Research
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00280-008-0827-2/MediaObjects/280_2008_827_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00280-008-0827-2/MediaObjects/280_2008_827_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00280-008-0827-2/MediaObjects/280_2008_827_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00280-008-0827-2/MediaObjects/280_2008_827_Fig4_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00280-008-0827-2/MediaObjects/280_2008_827_Fig5_HTML.gif
isPartOf:
name:Cancer Chemotherapy and Pharmacology
issn:
1432-0843
0344-5704
volumeNumber:63
type:
Periodical
PublicationVolume
publisher:
name:Springer-Verlag
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Jürgen B. Bulitta
affiliation:
name:University at Buffalo, State University of New York
address:
name:Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, USA
type:PostalAddress
type:Organization
type:Person
name:Ping Zhao
affiliation:
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
type:Organization
type:Person
name:Robert D. Arnold
affiliation:
name:University at Buffalo, State University of New York
address:
name:Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, USA
type:PostalAddress
type:Organization
name:University of Georgia
address:
name:Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, USA
type:PostalAddress
type:Organization
type:Person
name:Dean R. Kessler
affiliation:
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
type:Organization
type:Person
name:Richard Daifuku
affiliation:
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
type:Organization
type:Person
name:James Pratt
affiliation:
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
type:Organization
type:Person
name:Gabriel Luciano
affiliation:
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
type:Organization
type:Person
name:Axel-R Hanauske
affiliation:
name:St. Georg Hospital
address:
name:Department of Medical Oncology, St. Georg Hospital, Hamburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Hans Gelderblom
affiliation:
name:Leiden University Medical Center
address:
name:Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
type:PostalAddress
type:Organization
type:Person
name:Ahmad Awada
affiliation:
name:Institut Jules Bordet
address:
name:Institut Jules Bordet, Brussels, Belgium
type:PostalAddress
type:Organization
type:Person
name:William J. Jusko
affiliation:
name:University at Buffalo, State University of New York
address:
name:Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Cancer Chemotherapy and Pharmacology
issn:
1432-0843
0344-5704
volumeNumber:63
Organization:
name:Springer-Verlag
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:University at Buffalo, State University of New York
address:
name:Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, USA
type:PostalAddress
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
name:University at Buffalo, State University of New York
address:
name:Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, USA
type:PostalAddress
name:University of Georgia
address:
name:Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, USA
type:PostalAddress
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
name:St. Georg Hospital
address:
name:Department of Medical Oncology, St. Georg Hospital, Hamburg, Germany
type:PostalAddress
name:Leiden University Medical Center
address:
name:Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
type:PostalAddress
name:Institut Jules Bordet
address:
name:Institut Jules Bordet, Brussels, Belgium
type:PostalAddress
name:University at Buffalo, State University of New York
address:
name:Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Jürgen B. Bulitta
affiliation:
name:University at Buffalo, State University of New York
address:
name:Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, USA
type:PostalAddress
type:Organization
name:Ping Zhao
affiliation:
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
type:Organization
name:Robert D. Arnold
affiliation:
name:University at Buffalo, State University of New York
address:
name:Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, USA
type:PostalAddress
type:Organization
name:University of Georgia
address:
name:Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, USA
type:PostalAddress
type:Organization
name:Dean R. Kessler
affiliation:
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
type:Organization
name:Richard Daifuku
affiliation:
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
type:Organization
name:James Pratt
affiliation:
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
type:Organization
name:Gabriel Luciano
affiliation:
name:Sonus Pharmaceuticals, Inc.
address:
name:Sonus Pharmaceuticals, Inc., Bothell, USA
type:PostalAddress
type:Organization
name:Axel-R Hanauske
affiliation:
name:St. Georg Hospital
address:
name:Department of Medical Oncology, St. Georg Hospital, Hamburg, Germany
type:PostalAddress
type:Organization
name:Hans Gelderblom
affiliation:
name:Leiden University Medical Center
address:
name:Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
type:PostalAddress
type:Organization
name:Ahmad Awada
affiliation:
name:Institut Jules Bordet
address:
name:Institut Jules Bordet, Brussels, Belgium
type:PostalAddress
type:Organization
name:William J. Jusko
affiliation:
name:University at Buffalo, State University of New York
address:
name:Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, USA
name:Sonus Pharmaceuticals, Inc., Bothell, USA
name:Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, USA
name:Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, USA
name:Sonus Pharmaceuticals, Inc., Bothell, USA
name:Sonus Pharmaceuticals, Inc., Bothell, USA
name:Sonus Pharmaceuticals, Inc., Bothell, USA
name:Sonus Pharmaceuticals, Inc., Bothell, USA
name:Department of Medical Oncology, St. Georg Hospital, Hamburg, Germany
name:Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
name:Institut Jules Bordet, Brussels, Belgium
name:Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, USA
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(156)
- Check the income stats for https://www.springernature.com/gp/authors
- Get to know what's the income of https://link.springernature.com/home/
- How much does https://order.springer.com/public/cart make?
- https://submission.springernature.com/new-submission/280/3 income
- How much revenue does https://www.springernature.com/gp/librarians/licensing/agc/journals generate?
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=NONMEM%20Users%20Guides%20%281989%E2%80%932006%29&publication_year=2006&author=Beal%2CSL&author=Sheiner%2CLB&author=Boeckmann%2CAJ?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1578386 make?
- Earnings of http://scholar.google.com/scholar_lookup?&title=Emulsifier%20for%20intravenous%20cyclosporin%20inhibits%20neurite%20outgrowth%2C%20causes%20deficits%20in%20rapid%20axonal%20transport%20and%20leads%20to%20structural%20abnormalities%20in%20differentiating%20N1E.115%20neuroblastoma&journal=J%20Pharmacol%20Exp%20Ther&volume=261&pages=803-810&publication_year=1992&author=Brat%2CDJ&author=Windebank%2CAJ&author=Brimijoin%2CS
- How profitable is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10997930?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Measurement%20of%20fraction%20unbound%20paclitaxel%20in%20human%20plasma&journal=Drug%20Metab%20Dispos&volume=28&pages=1141-1145&publication_year=2000&author=Brouwer%2CE&author=Verweij%2CJ&author=Bruijn%2CP&author=Loos%2CWJ&author=Pillay%2CM&author=Buijs%2CD&author=Sparreboom%2CA
- Learn about the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1675263
- How much money does http://scholar.google.com/scholar_lookup?&title=A%20phase%20I%20trial%20of%20taxol%20given%20by%20a%206-hour%20intravenous%20infusion&journal=J%20Clin%20Oncol&volume=9&pages=1261-1267&publication_year=1991&author=Brown%2CT&author=Havlin%2CK&author=Weiss%2CG&author=Cagnola%2CJ&author=Koeller%2CJ&author=Kuhn%2CJ&author=Rizzo%2CJ&author=Craig%2CJ&author=Phillips%2CJ&author=Hoff%2CD generate?
- Financial intake of https://doi.org/10.1023%2FA%3A1007565230130
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10751032 net monthly?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Formulation%20development%20and%20antitumor%20activity%20of%20a%20filter-sterilizable%20emulsion%20of%20paclitaxel&journal=Pharm%20Res&doi=10.1023%2FA%3A1007565230130&volume=17&pages=175-182&publication_year=2000&author=Constantinides%2CPP&author=Lambert%2CKJ&author=Tustian%2CAK&author=Schneider%2CB&author=Lalji%2CS&author=Ma%2CW&author=Wentzel%2CB&author=Kessler%2CD&author=Worah%2CD&author=Quay%2CSC?
- What are the earnings of https://doi.org/10.1016%2Fj.addr.2003.12.005?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15109767 gross monthly?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Tocol%20emulsions%20for%20drug%20solubilization%20and%20parenteral%20delivery&journal=Adv%20Drug%20Deliv%20Rev&doi=10.1016%2Fj.addr.2003.12.005&volume=56&pages=1243-1255&publication_year=2004&author=Constantinides%2CPP&author=Tustian%2CA&author=Kessler%2CDR each month?
- What are the earnings of https://doi.org/10.1358%2Fmf.2001.23.2.627937?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11484417 generate monthly?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Pharmacokinetic%20study%20of%20paclitaxel%20as%20a%203-hour%20infusion%20in%20an%20Indian%20population%3A%20135%C2%A0mg%2Fm2%20vs.%20175%C2%A0mg%2Fm2&journal=Methods%20Find%20Exp%20Clin%20Pharmacol&doi=10.1358%2Fmf.2001.23.2.627937&volume=23&pages=93-98&publication_year=2001&author=Dhanikula%2CAB&author=Panchagnula%2CR&author=Singh%2CI&author=Kaur%2CKJ&author=Kaul%2CCL&author=Sekhon%2CJS produce monthly?
- What is the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7915152?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Pharmacology%20and%20toxicology%20of%20Cremophor%20EL%20diluent&journal=Ann%20Pharmacother&volume=28&pages=S11-S14&publication_year=1994&author=Dorr%2CRT make?
- Earnings of https://doi.org/10.1200%2FJCO.20.2.574
- How much income is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11786588 earning monthly?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Comparative%20pharmacokinetics%20of%20unbound%20paclitaxel%20during%201-%20and%203-hour%20infusions&journal=J%20Clin%20Oncol&doi=10.1200%2FJCO.20.2.574&volume=20&pages=574-581&publication_year=2002&author=Gelderblom%2CH&author=Mross%2CK&author=ten%20Tije%2CAJ&author=Behringer%2CD&author=Mielke%2CS&author=Zomeren%2CDM&author=Verweij%2CJ&author=Sparreboom%2CA?
- What is the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10534315?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Disposition%20of%20%5BG-%283%29H%5Dpaclitaxel%20and%20cremophor%20EL%20in%20a%20patient%20with%20severely%20impaired%20renal%20function&journal=Drug%20Metab%20Dispos&volume=27&pages=1300-1305&publication_year=1999&author=Gelderblom%2CH&author=Verweij%2CJ&author=Brouwer%2CE&author=Pillay%2CM&author=Bruijn%2CP&author=Nooter%2CK&author=Stoter%2CG&author=Sparreboom%2CA bring in?
- Profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7799018
- What's http://scholar.google.com/scholar_lookup?&title=Nonlinear%20pharmacokinetics%20and%20metabolism%20of%20paclitaxel%20and%20its%20pharmacokinetic%2Fpharmacodynamic%20relationships%20in%20humans&journal=J%20Clin%20Oncol&volume=13&pages=180-190&publication_year=1995&author=Gianni%2CL&author=Kearns%2CCM&author=Giani%2CA&author=Capri%2CG&author=Vigano%2CL&author=Lacatelli%2CA&author=Bonadonna%2CG&author=Egorin%2CMJ's gross income?
- See how much https://doi.org/10.1263%2Fjbb.102.369 makes per month
- How profitable is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17116587?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Enhancement%20of%20water-solubility%20and%20bioactivity%20of%20paclitaxel%20using%20modified%20cyclodextrins&journal=J%20Biosci%20Bioeng&doi=10.1263%2Fjbb.102.369&volume=102&pages=369-371&publication_year=2006&author=Hamada%2CH&author=Ishihara%2CK&author=Masuoka%2CN&author=Mikuni%2CK&author=Nakajima%2CN bring in?
- How much money does https://doi.org/10.1097%2F00001813-200307000-00005 make?
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12853882 bring in?
- How much does http://scholar.google.com/scholar_lookup?&title=Population%20pharmacokinetics%20of%20low-dose%20paclitaxel%20in%20patients%20with%20brain%20tumors&journal=Anticancer%20Drugs&doi=10.1097%2F00001813-200307000-00005&volume=14&pages=417-422&publication_year=2003&author=Hempel%2CG&author=Rube%2CC&author=Mosler%2CC&author=Wienstroer%2CM&author=Wagner-Bohn%2CA&author=Schuck%2CA&author=Willich%2CN&author=Boos%2CJ make?
- Explore the financials of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11600609
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Mechanism-based%20pharmacokinetic%20model%20for%20paclitaxel&journal=J%20Clin%20Oncol&volume=19&pages=4065-4073&publication_year=2001&author=Henningsson%2CA&author=Karlsson%2CMO&author=Vigano%2CL&author=Gianni%2CL&author=Verweij%2CJ&author=Sparreboom%2CA?
- https://doi.org/10.1158%2F1078-0432.CCR-05-1152's financial summary
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16299241 bring in each month?
- How profitable is http://scholar.google.com/scholar_lookup?&title=Association%20of%20CYP2C8%2C%20CYP3A4%2C%20CYP3A5%2C%20and%20ABCB1%20polymorphisms%20with%20the%20pharmacokinetics%20of%20paclitaxel&journal=Clin%20Cancer%20Res&doi=10.1158%2F1078-0432.CCR-05-1152&volume=11&pages=8097-8104&publication_year=2005&author=Henningsson%2CA&author=Marsh%2CS&author=Loos%2CWJ&author=Karlsson%2CMO&author=Garsa%2CA&author=Mross%2CK&author=Mielke%2CS&author=Vigano%2CL&author=Locatelli%2CA&author=Verweij%2CJ&author=Sparreboom%2CA&author=McLeod%2CHL?
- What's https://doi.org/10.1016%2FS0959-8049%2803%2900126-6's gross income?
- Income figures for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12736110
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Population%20pharmacokinetic%20modelling%20of%20unbound%20and%20total%20plasma%20concentrations%20of%20paclitaxel%20in%20cancer%20patients&journal=Eur%20J%20Cancer&doi=10.1016%2FS0959-8049%2803%2900126-6&volume=39&pages=1105-1114&publication_year=2003&author=Henningsson%2CA&author=Sparreboom%2CA&author=Sandstrom%2CM&author=Freijs%2CA&author=Larsson%2CR&author=Bergh%2CJ&author=Nygren%2CP&author=Karlsson%2CMO generate?
- What's the financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12006516?
- How much does http://scholar.google.com/scholar_lookup?&title=Phase%20I%20and%20pharmacokinetic%20study%20of%20ABI-007%2C%20a%20Cremophor-free%2C%20protein-stabilized%2C%20nanoparticle%20formulation%20of%20paclitaxel&journal=Clin%20Cancer%20Res&volume=8&pages=1038-1044&publication_year=2002&author=Ibrahim%2CNK&author=Desai%2CN&author=Legha%2CS&author=Soon-Shiong%2CP&author=Theriault%2CRL&author=Rivera%2CE&author=Esmaeli%2CB&author=Ring%2CSE&author=Bedikian%2CA&author=Hortobagyi%2CGN&author=Ellerhorst%2CJA rake in every month?
- How much income does https://doi.org/10.1158%2F1078-0432.CCR-05-2069 have?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16609028 rake in every month?
- Earnings of http://scholar.google.com/scholar_lookup?&title=Quantitative%20effect%20of%20gender%2C%20age%2C%20liver%20function%2C%20and%20body%20size%20on%20the%20population%20pharmacokinetics%20of%20Paclitaxel%20in%20patients%20with%20solid%20tumors&journal=Clin%20Cancer%20Res&doi=10.1158%2F1078-0432.CCR-05-2069&volume=12&pages=2150-2157&publication_year=2006&author=Joerger%2CM&author=Huitema%2CAD&author=Bongard%2CDH&author=Schellens%2CJH&author=Beijnen%2CJH
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10497151 pull in?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Pharmacokinetic%20models%20for%20the%20saturable%20distribution%20of%20paclitaxel&journal=Drug%20Metab%20Dispos&volume=27&pages=1220-1223&publication_year=1999&author=Karlsson%2CMO&author=Molnar%2CV&author=Freijs%2CA&author=Nygren%2CP&author=Bergh%2CJ&author=Larsson%2CR?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7597430 net monthly?
- http://scholar.google.com/scholar_lookup?&title=Paclitaxel%20pharmacokinetics%20and%20pharmacodynamics&journal=Semin%20Oncol&volume=22&pages=16-23&publication_year=1995&author=Kearns%2CCM&author=Gianni%2CL&author=Egorin%2CMJ's revenue stream
- How much profit is https://doi.org/10.1111%2Fj.1751-1097.1992.tb02187.x making per month?
- What is the monthly revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1454875?
- How profitable is http://scholar.google.com/scholar_lookup?&title=Properties%20of%20cremophor%20EL%20micelles%20probed%20by%20fluorescence&journal=Photochem%20Photobiol&doi=10.1111%2Fj.1751-1097.1992.tb02187.x&volume=56&pages=447-451&publication_year=1992&author=Kessel%2CD?
- Profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8102493
- Find out how much http://scholar.google.com/scholar_lookup?&title=Binding%20of%20taxol%20to%20human%20plasma%2C%20albumin%20and%20alpha%201-acid%20glycoprotein&journal=Res%20Commun%20Chem%20Pathol%20Pharmacol&volume=80&pages=337-344&publication_year=1993&author=Kumar%2CGN&author=Walle%2CUK&author=Bhalla%2CKN&author=Walle%2CT earns monthly
- What's the monthly income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7912528?
- http://scholar.google.com/scholar_lookup?&title=Hepatic%20metabolism%20and%20biliary%20excretion%20of%20Taxol%20in%20rats%20and%20humans&journal=J%20Natl%20Cancer%20Inst%20Monogr&volume=15&pages=39-46&publication_year=1993&author=Monsarrat%2CB&author=Alvinerie%2CP&author=Wright%2CM&author=Dubois%2CJ&author=Gueritte-Voegelein%2CF&author=Guenard%2CD&author=Donehower%2CRC&author=Rowinsky%2CEK's total income per month
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=3657876 net monthly?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Simplified%20calculation%20of%20body-surface%20area&journal=N%20Engl%20J%20Med&volume=317&publication_year=1987&author=Mosteller%2CRD generate?
- What's the income generated by https://doi.org/10.1111%2Fj.1365-2125.2006.02718.x each month?
- What's the income generated by http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16842379 each month?
- What's http://scholar.google.com/scholar_lookup?&title=Population%20analysis%20of%20a%2024-h%20paclitaxel%20infusion%20in%20advanced%20endometrial%20cancer%3A%20a%20gynaecological%20oncology%20group%20study&journal=Br%20J%20Clin%20Pharmacol&doi=10.1111%2Fj.1365-2125.2006.02718.x&volume=62&pages=56-70&publication_year=2006&author=Mould%2CDR&author=Fleming%2CGF&author=Darcy%2CKM&author=Spriggs%2CD's gross income?
- How much profit does https://doi.org/10.1097%2F00000421-198212000-00014 generate?
- How much income is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7165009 earning monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Toxicity%20and%20response%20criteria%20of%20the%20Eastern%20Cooperative%20Oncology%20Group&journal=Am%20J%20Clin%20Oncol&doi=10.1097%2F00000421-198212000-00014&volume=5&pages=649-655&publication_year=1982&author=Oken%2CMM&author=Creech%2CRH&author=Tormey%2CDC&author=Horton%2CJ&author=Davis%2CTE&author=McFadden%2CET&author=Carbone%2CPP earn?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8102012 pull in monthly?
- http://scholar.google.com/scholar_lookup?&title=Clinical%20toxicities%20encountered%20with%20paclitaxel%20%28Taxol%29&journal=Semin%20Oncol&volume=20&pages=1-15&publication_year=1993&author=Rowinsky%2CEK&author=Eisenhauer%2CEA&author=Chaudhry%2CV&author=Arbuck%2CSG&author=Donehower%2CRC income
- How much does https://doi.org/10.2174%2F156720105774370159 pull in monthly?
- What is the monthly revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16305440?
- How much income does http://scholar.google.com/scholar_lookup?&title=Ligand-targeted%20liposomes%20for%20cancer%20treatment&journal=Curr%20Drug%20Deliv&doi=10.2174%2F156720105774370159&volume=2&pages=369-381&publication_year=2005&author=Sapra%2CP&author=Tyagi%2CP&author=Allen%2CTM have?
- See how much https://doi.org/10.1002%2Fjps.2600841015 makes per month
- Discover the revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8801338
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Pharmaceutical%20and%20physical%20properties%20of%20paclitaxel%20%28Taxol%29%20complexes%20with%20cyclodextrins&journal=J%20Pharm%20Sci&doi=10.1002%2Fjps.2600841015&volume=84&pages=1223-1230&publication_year=1995&author=Sharma%2CUS&author=Balasubramanian%2CSV&author=Straubinger%2CRM?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7907130 rake in every month?
- What's http://scholar.google.com/scholar_lookup?&title=Saturable%20pharmacokinetics%20and%20paclitaxel%20pharmacodynamics%20in%20children%20with%20solid%20tumors&journal=J%20Clin%20Oncol&volume=12&pages=532-538&publication_year=1994&author=Sonnichsen%2CDS&author=Hurwitz%2CCA&author=Pratt%2CCB&author=Shuster%2CJJ&author=Relling%2CMV's gross income?
- How much money does https://doi.org/10.1006%2Fabio.1997.2467 make?
- What's the financial outcome of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9451500?
- How much does http://scholar.google.com/scholar_lookup?&title=Quantitation%20of%20Cremophor%20EL%20in%20human%20plasma%20samples%20using%20a%20colorimetric%20dye-binding%20microassay&journal=Anal%20Biochem&doi=10.1006%2Fabio.1997.2467&volume=255&pages=171-175&publication_year=1998&author=Sparreboom%2CA&author=Loos%2CWJ&author=Verweij%2CJ&author=Vos%2CAI&author=Burg%2CME&author=Stoter%2CG&author=Nooter%2CK gross monthly?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8616858 pull in?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Nonlinear%20pharmacokinetics%20of%20paclitaxel%20in%20mice%20results%20from%20the%20pharmaceutical%20vehicle%20Cremophor%20EL&journal=Cancer%20Res&volume=56&pages=2112-2115&publication_year=1996&author=Sparreboom%2CA&author=Tellingen%2CO&author=Nooijen%2CWJ&author=Beijnen%2CJH?
- How much does https://doi.org/10.1097%2F00001813-199601000-00009 net monthly?
- What's the income generated by http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8742102 each month?
- How much does http://scholar.google.com/scholar_lookup?&title=Tissue%20distribution%2C%20metabolism%20and%20excretion%20of%20paclitaxel%20in%20mice&journal=Anticancer%20Drugs&doi=10.1097%2F00001813-199601000-00009&volume=7&pages=78-86&publication_year=1996&author=Sparreboom%2CA&author=Tellingen%2CO&author=Nooijen%2CWJ&author=Beijnen%2CJH pull in?
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10197613 produce monthly?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Cremophor%20EL-mediated%20alteration%20of%20paclitaxel%20distribution%20in%20human%20blood%3A%20clinical%20pharmacokinetic%20implications&journal=Cancer%20Res&volume=59&pages=1454-1457&publication_year=1999&author=Sparreboom%2CA&author=Zuylen%2CL&author=Brouwer%2CE&author=Loos%2CWJ&author=Bruijn%2CP&author=Gelderblom%2CH&author=Pillay%2CM&author=Nooter%2CK&author=Stoter%2CG&author=Verweij%2CJ?
- Discover the revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9717822
- What's the income of http://scholar.google.com/scholar_lookup?&title=Disposition%20of%20Cremophor%20EL%20in%20humans%20limits%20the%20potential%20for%20modulation%20of%20the%20multidrug%20resistance%20phenotype%20in%20vivo&journal=Clin%20Cancer%20Res&volume=4&pages=1937-1942&publication_year=1998&author=Sparreboom%2CA&author=Verweij%2CJ&author=Burg%2CME&author=Loos%2CWJ&author=Brouwer%2CE&author=Vigano%2CL&author=Locatelli%2CA&author=Vos%2CAI&author=Nooter%2CK&author=Stoter%2CG&author=Gianni%2CL?
- How much does https://doi.org/10.1016%2FS0076-6879%2805%2991005-7 earn?
- Financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15721376
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Preparation%20and%20characterization%20of%20taxane-containing%20liposomes&journal=Methods%20Enzymol&doi=10.1016%2FS0076-6879%2805%2991005-7&volume=391&pages=97-117&publication_year=2005&author=Straubinger%2CRM&author=Balasubramanian%2CSV
- Get to know http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12111107's earnings
- Profit of http://scholar.google.com/scholar_lookup?&title=A%20population%20analysis%20of%20the%20pharmacokinetics%20of%20Cremophor%20EL%20using%20nonlinear%20mixed-effect%20modelling&journal=Cancer%20Chemother%20Pharmacol&doi=10.1007%2Fs00280-002-0459-x&volume=50&pages=16-24&publication_year=2002&author=Bongard%2CHJ&author=Mathot%2CRA&author=Tellingen%2CO&author=Schellens%2CJH&author=Beijnen%2CJH
- Learn about the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10537361
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Rapid%20esterase-sensitive%20breakdown%20of%20polysorbate%2080%20and%20its%20impact%20on%20the%20plasma%20pharmacokinetics%20of%20docetaxel%20and%20metabolites%20in%20mice&journal=Clin%20Cancer%20Res&volume=5&pages=2918-2924&publication_year=1999&author=Tellingen%2CO&author=Beijnen%2CJH&author=Verweij%2CJ&author=Scherrenburg%2CEJ&author=Nooijen%2CWJ&author=Sparreboom%2CA
- Financial intake of https://doi.org/10.1038%2Fsj.bjc.6690696
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10496361 generate monthly?
- What's http://scholar.google.com/scholar_lookup?&title=Cremophor%20EL%20causes%20%28pseudo-%29%20non-linear%20pharmacokinetics%20of%20paclitaxel%20in%20patients&journal=Br%20J%20Cancer&doi=10.1038%2Fsj.bjc.6690696&volume=81&pages=330-335&publication_year=1999&author=Tellingen%2CO&author=Huizing%2CMT&author=Panday%2CVR&author=Schellens%2CJH&author=Nooijen%2CWJ&author=Beijnen%2CJH's gross income?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11345647's total income per month
- Earnings of http://scholar.google.com/scholar_lookup?&title=Pharmacokinetic%20modeling%20of%20paclitaxel%20encapsulation%20in%20Cremophor%20EL%20micelles&journal=Cancer%20Chemother%20Pharmacol&doi=10.1007%2Fs002800000215&volume=47&pages=309-318&publication_year=2001&author=Zuylen%2CL&author=Karlsson%2CMO&author=Verweij%2CJ&author=Brouwer%2CE&author=Bruijn%2CP&author=Nooter%2CK&author=Stoter%2CG&author=Sparreboom%2CA
- https://doi.org/10.1023%2FA%3A1010618632738's revenue stream
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11392447 bring in each month?
- What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Role%20of%20formulation%20vehicles%20in%20taxane%20pharmacology&journal=Invest%20New%20Drugs&doi=10.1023%2FA%3A1010618632738&volume=19&pages=125-141&publication_year=2001&author=Zuylen%2CL&author=Verweij%2CJ&author=Sparreboom%2CA?
- Financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7600920
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Taxol%20metabolism%20and%20disposition%20in%20cancer%20patients&journal=Drug%20Metab%20Dispos&volume=23&pages=506-512&publication_year=1995&author=Walle%2CT&author=Walle%2CUK&author=Kumar%2CGN&author=Bhalla%2CKN?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1972736's financial summary
- How much does http://scholar.google.com/scholar_lookup?&title=Hypersensitivity%20reactions%20from%20taxol&journal=J%20Clin%20Oncol&volume=8&pages=1263-1268&publication_year=1990&author=Weiss%2CRB&author=Donehower%2CRC&author=Wiernik%2CPH&author=Ohnuma%2CT&author=Gralla%2CRJ&author=Trump%2CDL&author=Baker%2CJR&author=Echo%2CDA&author=Hoff%2CDD&author=Leyland-Jones%2CB pull in?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2887641's total income per month
- Income figures for http://scholar.google.com/scholar_lookup?&title=Phase%20I%20trial%20of%20taxol%20given%20as%20a%2024-hour%20infusion%20every%2021%C2%A0days%3A%20responses%20observed%20in%20metastatic%20melanoma&journal=J%20Clin%20Oncol&volume=5&pages=1232-1239&publication_year=1987&author=Wiernik%2CPH&author=Schwartz%2CEL&author=Einzig%2CA&author=Strauman%2CJJ&author=Lipton%2CRB&author=Dutcher%2CJP
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7720174 generate?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Extensive%20and%20saturable%20accumulation%20of%20paclitaxel%20by%20the%20human%20platelet&journal=Cancer%20Chemother%20Pharmacol&doi=10.1007%2FBF00685730&volume=36&pages=41-44&publication_year=1995&author=Wild%2CMD&author=Walle%2CUK&author=Walle%2CT?
- What's the revenue for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8113961?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=Potential%20neurotoxicity%20of%20the%20solvent%20vehicle%20for%20cyclosporine&journal=J%20Pharmacol%20Exp%20Ther&volume=268&pages=1051-1056&publication_year=1994&author=Windebank%2CAJ&author=Blexrud%2CMD&author=Groen%2CPC
- https://citation-needed.springer.com/v2/references/10.1007/s00280-008-0827-2?format=refman&flavour=references's financial summary
- What is the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=J%C3%BCrgen%20B.%20Bulitta?
- See how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22J%C3%BCrgen%20B.%20Bulitta%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en makes per month
- How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ping%20Zhao make?
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ping%20Zhao%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's revenue stream
- How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Robert%20D.%20Arnold make?
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Robert%20D.%20Arnold%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's revenue stream
- What's the profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dean%20R.%20Kessler?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Dean%20R.%20Kessler%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- Learn how profitable https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Richard%20Daifuku is on a monthly basis
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Richard%20Daifuku%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in?
- Profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=James%20Pratt
- Income figures for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22James%20Pratt%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Gabriel%20Luciano generate?
- Get to know https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Gabriel%20Luciano%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's earnings
- What are the total earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Axel-R%20Hanauske?
- What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Axel-R%20Hanauske%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hans%20Gelderblom generate?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Hans%20Gelderblom%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en net monthly?
- What's the monthly money flow for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ahmad%20Awada?
- How profitable is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ahmad%20Awada%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Learn about the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=William%20J.%20Jusko
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22William%20J.%20Jusko%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's total income per month
- Income figures for https://s100.copyright.com/AppDispatchServlet?title=Mechanistic%20population%20pharmacokinetics%20of%20total%20and%20unbound%20paclitaxel%20for%20a%20new%20nanodroplet%20formulation%20versus%20Taxol%20in%20cancer%20patients&author=J%C3%BCrgen%20B.%20Bulitta%20et%20al&contentID=10.1007%2Fs00280-008-0827-2©right=Springer-Verlag&publication=0344-5704&publicationDate=2008-09-13&publisherName=SpringerNature&orderBeanReset=true
- How much does https://citation-needed.springer.com/v2/references/10.1007/s00280-008-0827-2?format=refman&flavour=citation bring in each month?
- What is the earnings of https://authorservices.springernature.com/go/sn/?utm_source=SNLinkfooter&utm_medium=Web&utm_campaign=SNReferral?
- What's the total monthly financial gain of https://www.springernature.com/gp/open-research/about/the-fundamentals-of-open-access-and-open-research?
- What's https://www.springernature.com/gp/products's gross income?
- How much does https://www.springernature.com/gp/librarians bring in each month?
- How much income is https://www.springernature.com/gp/societies earning monthly?
- How much profit is https://www.springernature.com/gp/partners making per month?
- https://www.springer.com/ income
- How much does https://www.nature.com/ earn?
- What's the total monthly financial gain of https://www.biomedcentral.com/?
- How much revenue does https://www.palgrave.com/ generate?
- What are the earnings of https://www.apress.com/?
- How much revenue does https://www.springernature.com/gp/legal/ccpa bring in?
- What's the monthly money flow for https://www.springernature.com/gp/info/accessibility?
- What's the financial intake of https://support.springernature.com/en/support/home?
- How much does https://support.springernature.com/en/support/solutions/articles/6000255911-subscription-cancellations bring in each month?
- Explore the financials of https://www.springernature.com/
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Clipboard.js
- Prism.js
CDN Services {📦}
- Crossref