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Title:
Epstein-Barr virus-associated persistent polyclonal B-cell lymphocytosis with a distinct 69-base pair deletion in the LMP1 oncogene | Annals of Hematology
Description:
Epstein-Barr virus (EBV) genomes have been detected in peripheral blood lymphocytes (PBL) of patients with persistent polyclonal B-cell lymphocytosis (PPBL). This is consistent with the hypothesis that latent EBV infection is involved in the pathogenesis of this disorder. Two EBV-encoded proteins expressed in viral latency are the latent membrane proteins 1 and 2A (LMP1 and LMP2A). We have studied the LMP1 oncogene and the LMP2A gene in a female patient with PPBL and her five siblings. A cell line derived from peripheral blood lymphocytes (PBL) of the patient was also analyzed. A distinct 69-base pair deletion was identified within the carboxy terminal NF-κB activation domain of the LMP1 oncogene in PBL of the patient and in the cell line, whereas none of the siblings harbored this deletion. The tyrosine-signaling motif and the HLA A2.1 epitope of the LMP2A gene were wild type in the patient and all siblings. The presence of a 69-base pair deletion variant of the LMP1 oncogene within the lymphocytes of a PPBL patient but absence of this deletion variant in the unaffected siblings suggests a direct implication of altered LMP1 oncoprotein-dependent function in the pathogenesis of PPBL.
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article, lmp, oncogene, epsteinbarr, deletion, privacy, cookies, content, virus, patient, access, information, publish, search, bcell, lymphocytosis, base, pair, ppbl, lmpa, siblings, cell, data, log, journal, research, hematology, persistent, polyclonal, distinct, larcher, mcquain, berger, lymphocytes, pbl, latent, proteins, lymphoma, discover, springer, function, optional, personal, parties, policy, find, track, annals, virusassociated, cite,
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epstein-barr virus ebv-encoded proteins expressed cell lymphoma month download article/chapter privacy choices/manage cookies related subjects cell line derived full article pdf latent ebv infection european economic area scope submit manuscript tyrosine-signaling motif conditions privacy policy massachusetts medical center peripheral blood lymphocytes accepting optional cookies check access instant access unaffected siblings suggests lmp1 oncogene article annals cell line journal finder publish cell lines 2a article log deletion variant protein expression privacy policy personal data information article cite books a article larcher optional cookies manage preferences 30-bp deletion knecht division subscription content similar content data protection hematology aims essential cookies cookies skip cancer center institution subscribe journal publish usage analysis social media varying standards
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headline:Epstein-Barr virus-associated persistent polyclonal B-cell lymphocytosis with a distinct 69-base pair deletion in the LMP1 oncogene
description: Epstein-Barr virus (EBV) genomes have been detected in peripheral blood lymphocytes (PBL) of patients with persistent polyclonal B-cell lymphocytosis (PPBL). This is consistent with the hypothesis that latent EBV infection is involved in the pathogenesis of this disorder. Two EBV-encoded proteins expressed in viral latency are the latent membrane proteins 1 and 2A (LMP1 and LMP2A). We have studied the LMP1 oncogene and the LMP2A gene in a female patient with PPBL and her five siblings. A cell line derived from peripheral blood lymphocytes (PBL) of the patient was also analyzed. A distinct 69-base pair deletion was identified within the carboxy terminal NF-κB activation domain of the LMP1 oncogene in PBL of the patient and in the cell line, whereas none of the siblings harbored this deletion. The tyrosine-signaling motif and the HLA A2.1 epitope of the LMP2A gene were wild type in the patient and all siblings. The presence of a 69-base pair deletion variant of the LMP1 oncogene within the lymphocytes of a PPBL patient but absence of this deletion variant in the unaffected siblings suggests a direct implication of altered LMP1 oncoprotein-dependent function in the pathogenesis of PPBL.
datePublished:
dateModified:
pageStart:23
pageEnd:28
sameAs:https://doi.org/10.1007/s002770050250
keywords:
Key words Lymphocytosis
Epstein-Barr virus
LMP-1
LMP-2A
Kindred
Hematology
Oncology
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headline:Epstein-Barr virus-associated persistent polyclonal B-cell lymphocytosis with a distinct 69-base pair deletion in the LMP1 oncogene
description: Epstein-Barr virus (EBV) genomes have been detected in peripheral blood lymphocytes (PBL) of patients with persistent polyclonal B-cell lymphocytosis (PPBL). This is consistent with the hypothesis that latent EBV infection is involved in the pathogenesis of this disorder. Two EBV-encoded proteins expressed in viral latency are the latent membrane proteins 1 and 2A (LMP1 and LMP2A). We have studied the LMP1 oncogene and the LMP2A gene in a female patient with PPBL and her five siblings. A cell line derived from peripheral blood lymphocytes (PBL) of the patient was also analyzed. A distinct 69-base pair deletion was identified within the carboxy terminal NF-κB activation domain of the LMP1 oncogene in PBL of the patient and in the cell line, whereas none of the siblings harbored this deletion. The tyrosine-signaling motif and the HLA A2.1 epitope of the LMP2A gene were wild type in the patient and all siblings. The presence of a 69-base pair deletion variant of the LMP1 oncogene within the lymphocytes of a PPBL patient but absence of this deletion variant in the unaffected siblings suggests a direct implication of altered LMP1 oncoprotein-dependent function in the pathogenesis of PPBL.
datePublished:
dateModified:
pageStart:23
pageEnd:28
sameAs:https://doi.org/10.1007/s002770050250
keywords:
Key words Lymphocytosis
Epstein-Barr virus
LMP-1
LMP-2A
Kindred
Hematology
Oncology
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