We are analyzing https://link.springer.com/article/10.1007/s00277-018-3311-z.

Title:
Bendamustine and rituximab (BR) versus dexamethasone, rituximab, and cyclophosphamide (DRC) in patients with Waldenström macroglobulinemia | Annals of Hematology
Description:
The treatment approaches for Waldenstrom macroglobulinemia (WM) are largely based upon information from single-arm phase II trials, without comparative data. We compared the efficacy of two commonly used regimens in routine practice (bendamustine-rituximab (BR) and dexamethasone, rituximab plus cyclophosphamide (DRC)) and evaluated their activity with respect to the patients’ MYD88L265P mutation status. Of 160 consecutive patients, 60 received BR (43 with relapsed/refractory WM) and 100 received DRC (50 had relapsed/refractory WM). In the treatment-naïve setting, overall response rate (ORR) was 93% with BR versus 96% with DRC (p = 0.55). Two-year progression-free survival (PFS) with BR and DRC was 88 and 61%, respectively (p = 0.07). In salvage setting, ORR was 95% with BR versus 87% with DRC, p = 0.45; median PFS with BR was 58 versus 32 months with DRC (2-year PFS was 66 versus 53%; p = 0.08). Median disease-specific survival was not reached with BR versus 166 months with DRC (p = 0.51). The time-to-event endpoints and depth of response were independent of the MYD88 mutation status. Grade ≥ 3 adverse events of both regimens were comparable. A trend for longer PFS was observed with BR although the regimens have comparable toxicities. The activity of BR and DRC appears to be unaffected by patients’ MYD88 mutation status.
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Keywords {🔍}

article, pubmed, macroglobulinemia, google, scholar, cas, rituximab, research, patients, waldenstroms, treon, versus, bendamustine, waldenstrom, received, institution, study, drc, treatment, lymphoma, oncol, data, myd, therapy, celgene, cyclophosphamide, ansell, kyle, kapoor, phase, castillo, clin, gertz, mayo, funding, kumar, morra, patterson, hunter, ibrutinib, usa, privacy, cookies, content, information, hematology, dexamethasone, waldenström, paludo, lacy,

Topics {✒️}

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Questions {❓}

Jimenez R, Zhang B, Joffe S, Nilsson M, Rivera L, Mutchler J, Lathan C, Paulk ME, Prigerson HG (2013) Clinical trial participation among ethnic/racial minority and majority patients with advanced cancer: what factors most influence enrollment?

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      description:The treatment approaches for Waldenstrom macroglobulinemia (WM) are largely based upon information from single-arm phase II trials, without comparative data. We compared the efficacy of two commonly used regimens in routine practice (bendamustine-rituximab (BR) and dexamethasone, rituximab plus cyclophosphamide (DRC)) and evaluated their activity with respect to the patients’ MYD88L265P mutation status. Of 160 consecutive patients, 60 received BR (43 with relapsed/refractory WM) and 100 received DRC (50 had relapsed/refractory WM). In the treatment-naïve setting, overall response rate (ORR) was 93% with BR versus 96% with DRC (p = 0.55). Two-year progression-free survival (PFS) with BR and DRC was 88 and 61%, respectively (p = 0.07). In salvage setting, ORR was 95% with BR versus 87% with DRC, p = 0.45; median PFS with BR was 58 versus 32 months with DRC (2-year PFS was 66 versus 53%; p = 0.08). Median disease-specific survival was not reached with BR versus 166 months with DRC (p = 0.51). The time-to-event endpoints and depth of response were independent of the MYD88 mutation status. Grade ≥ 3 adverse events of both regimens were comparable. A trend for longer PFS was observed with BR although the regimens have comparable toxicities. The activity of BR and DRC appears to be unaffected by patients’ MYD88 mutation status.
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      email:[email protected]
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      name:Department of Internal Medicine, Mayo Clinic, Rochester, USA
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      name:Division of Hematology, Mayo Clinic, Rochester, USA
      name:Division of Hematology, Mayo Clinic, Jacksonville, USA
      name:Division of Hematopathology, Mayo Clinic, Rochester, USA
      name:Division of Hematology, Mayo Clinic, Rochester, USA
      name:Division of Hematology, Mayo Clinic, Scottsdale, USA
      name:Division of Hematology, Mayo Clinic, Rochester, USA
      name:Division of Hematology, Mayo Clinic, Rochester, USA
      name:Division of Hematology, Mayo Clinic, Rochester, USA
      name:Division of Hematology, Mayo Clinic, Rochester, USA
      name:Division of Hematology, Mayo Clinic, Rochester, USA
      name:Division of Hematology, Mayo Clinic, Rochester, USA
      name:Division of Hematology, Mayo Clinic, Rochester, USA
      name:Division of Hematology, Mayo Clinic, Rochester, USA
      name:Division of Hematology, Mayo Clinic, Rochester, USA
      name:Division of Hematology, Mayo Clinic, Rochester, USA
      name:Division of Hematology, Mayo Clinic, Rochester, USA
      name:Division of Hematology, Mayo Clinic, Rochester, USA
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