We are analyzing https://link.springer.com/article/10.1007/s00268-009-0070-y.

Title:
Overexpression and Interactions of Interleukin-10, Transforming Growth Factor β, and Vascular Endothelial Growth Factor in Esophageal Squamous Cell Carcinoma | World Journal of Surgery
Description:
Sharing the role of immune suppression, interleukin-10 (IL-10), transforming growth factor β (TGF-β), and vascular endothelial growth factor (VEGF) are critical genes in several aspects of tumorigenesis. To elucidate the role of these cytokines in esophageal squamous cell carcinoma (ESCC), their relative mRNA expression in tumoral tissue compared with corresponding tumor-free tissue was evaluated. A total of 49 patients with histologically confirmed ESCC were included in the study prior to any therapeutic interventions. Quantitative analysis of the mRNA expression was performed by real-time reverse transcription-polymerase chain reaction and the clinicopathologic associations were assessed. The mRNA of IL-10, VEGF, and TGF-β was frequently overexpressed in 53.2%, 44.9%, and 37.5% of ESCC patients, respectively. TGF-β was significantly co-expressed with IL-10 and with VEGF. Although VEGF was not independently associated with increased tumor size (p = 0.065), concomitant overexpression of VEGF with TGF-β was significantly correlated with increased size of the tumor (p < 0.05). Overexpression of IL-10, TGF-β, and VEGF plays an important role in ESCC and consequently leads to the frequent event of immune evasion in ESCC. TGF-β is concomitantly overexpressed with IL-10 and with VEGF in ESCC. A stimulatory signal from TGF-β to VEGF is necessary for VEGF to promote tumor progression.
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Keywords {🔍}

google, scholar, article, pubmed, cas, growth, factor, cancer, transforming, cell, vegf, expression, endothelial, esophageal, vascular, carcinoma, tgfβ, cells, human, tgfbeta, interleukin, squamous, immune, tumor, res, research, mohammad, mrna, role, escc, access, beta, iran, factorbeta, mashhad, privacy, cookies, content, journal, overexpression, reza, int, rev, immunol, analysis, data, publish, search, world, surgery,

Topics {✒️}

mohammad taghi rajabi-mashhadi transforming growth factor-beta transforming growth factor anti-tumour activity mohammad naser forghani month download article/chapter quantitative real-time pcr mohammad reza abbaszadegan tumor-induced immune suppression esophageal carcinoma human esophageal cancer related subjects immunology research center injury endothelial cells mhc class unfavorable prognostic factor promote tumor progression full article pdf tumor-free tissue article world journal privacy choices/manage cookies hossein naseh tumoral tissue compared esophageal cancer avicenna research institute check access instant access dendritic cell induction endothelial cells human melanoma cells mesenchymal stem cells vegf-targeted therapy tumor growth increased tumor size tgf-beta1 expression tgf-beta stimulation tumor–host interaction tumor-infiltrating lymphocytes important immune mediators bahram memar lymph node metastasis cell proliferation messenger rna expression true immunoregulatory cytokine european economic area isolated perfused microvessels emerging immunotherapeutic targets synthetic peptide homologous elevates nitric oxide relative mrna expression

Questions {❓}

Wakkach A, Cottrez F, Groux H (2000) Can interleukin-10 be used as a true immunoregulatory cytokine?

Schema {🗺️}

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         description:Sharing the role of immune suppression, interleukin-10 (IL-10), transforming growth factor β (TGF-β), and vascular endothelial growth factor (VEGF) are critical genes in several aspects of tumorigenesis. To elucidate the role of these cytokines in esophageal squamous cell carcinoma (ESCC), their relative mRNA expression in tumoral tissue compared with corresponding tumor-free tissue was evaluated. A total of 49 patients with histologically confirmed ESCC were included in the study prior to any therapeutic interventions. Quantitative analysis of the mRNA expression was performed by real-time reverse transcription-polymerase chain reaction and the clinicopathologic associations were assessed. The mRNA of IL-10, VEGF, and TGF-β was frequently overexpressed in 53.2%, 44.9%, and 37.5% of ESCC patients, respectively. TGF-β was significantly co-expressed with IL-10 and with VEGF. Although VEGF was not independently associated with increased tumor size (p = 0.065), concomitant overexpression of VEGF with TGF-β was significantly correlated with increased size of the tumor (p < 0.05). Overexpression of IL-10, TGF-β, and VEGF plays an important role in ESCC and consequently leads to the frequent event of immune evasion in ESCC. TGF-β is concomitantly overexpressed with IL-10 and with VEGF in ESCC. A stimulatory signal from TGF-β to VEGF is necessary for VEGF to promote tumor progression.
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         Cardiac Surgery
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