We are analyzing https://link.springer.com/article/10.1007/s00268-008-9552-6.

Title:
Preoperative Neutrophil-to-Lymphocyte Ratio as a Prognostic Predictor after Curative Resection for Hepatocellular Carcinoma | World Journal of Surgery
Description:
This study was designed to evaluate the impact of an elevated preoperative neutrophil-to-lymphocyte ratio (NLR) on outcome after curative resection for hepatocellular carcinoma (HCC). Patients undergoing resection for HCC from January 1994 to May 2007 were identified from the hepatobiliary database. Demographics, laboratory analyses, and histopathology data were analyzed. A total of 96 patients were identified with a median age at diagnosis of 65 (range, 15–85) years. The 1-, 3-, and 5-year overall survival rates were 80%, 58%, and 52%, respectively. Although the presence of microvascular invasion, NLR ≥5, and R1 resection margin were adverse predictors of overall survival, there were no independent predictors identified on multivariate analysis. The 1-, 3-, and 5-year disease-free survival rates were 74%, 63%, and 57%, respectively. Preoperative tumor biopsy, NLR ≥ 5, multiple liver tumors, microvascular invasion, and R1 resection margin were all predictors of poorer disease-free survival. Multivariate analysis showed that a NLR ≥ 5 and R1 resection margin were independent predictors of poorer disease-free survival. The median disease-free survival of those with a NLR ≥ 5 was 8 months compared with 18 months for those with a NLR < 5. Preoperative NLR ≥ 5 was an adverse predictor of disease-free and overall survival.
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article, pubmed, google, scholar, cas, carcinoma, resection, hepatocellular, cancer, liver, surg, survival, colorectal, patients, ratio, preoperative, prognostic, curative, analysis, oncol, toogood, nlr, hepatic, factors, recurrence, predictor, malik, lodge, prasad, diseasefree, metastases, privacy, cookies, content, journal, neutrophiltolymphocyte, study, outcome, results, predictors, access, ann, data, publish, search, surgery, gomez, multivariate, tumor, neutrophil,

Topics {✒️}

month download article/chapter poorer disease-free survival median disease-free survival multiple liver tumors tumour t-lymphocyte infiltration nitric oxide-dependent mechanism predicting long-term mortality cea-loaded dendritic cells serum c-reactive protein colorectal liver metastases microvascular invasion article world journal full article pdf prognostic factor disease-free long-term survival preoperative tumor biopsy el-assal systemic inflammatory response privacy choices/manage cookies c-reactive protein adverse predictor related subjects inhibit dna repair preserved liver function mcmillan dc metastatic colorectal cancer human gastric carcinoma acute-phase response percutaneous coronary intervention martinez-de-oliveira de vries ij stop preoperative biopsy colorectal cancer risk european economic area early death due underlying viral hepatitis form important compartments dth skin tests prognostic predictor hepatocellular carcinoma published hepatocellular carcinoma treated early hepatocellular carcinoma large hepatocellular carcinoma hepatocellular carcinoma greater small hepatocellular carcinoma check access instant access de boer aj conditions privacy policy

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Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow?

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         description:This study was designed to evaluate the impact of an elevated preoperative neutrophil-to-lymphocyte ratio (NLR) on outcome after curative resection for hepatocellular carcinoma (HCC). Patients undergoing resection for HCC from January 1994 to May 2007 were identified from the hepatobiliary database. Demographics, laboratory analyses, and histopathology data were analyzed. A total of 96 patients were identified with a median age at diagnosis of 65 (range, 15–85) years. The 1-, 3-, and 5-year overall survival rates were 80%, 58%, and 52%, respectively. Although the presence of microvascular invasion, NLR ≥5, and R1 resection margin were adverse predictors of overall survival, there were no independent predictors identified on multivariate analysis. The 1-, 3-, and 5-year disease-free survival rates were 74%, 63%, and 57%, respectively. Preoperative tumor biopsy, NLR ≥ 5, multiple liver tumors, microvascular invasion, and R1 resection margin were all predictors of poorer disease-free survival. Multivariate analysis showed that a NLR ≥ 5 and R1 resection margin were independent predictors of poorer disease-free survival. The median disease-free survival of those with a NLR ≥ 5 was 8 months compared with 18 months for those with a NLR < 5. Preoperative NLR ≥ 5 was an adverse predictor of disease-free and overall survival.
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            Cardiac Surgery
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         Cardiac Surgery
         General Surgery
         Thoracic Surgery
         Vascular Surgery
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