We are analyzing https://link.springer.com/article/10.1007/s00262-019-02427-4.

Title:
Role of regulatory T cells and checkpoint inhibition in hepatocellular carcinoma | Cancer Immunology, Immunotherapy
Description:
Immune checkpoint inhibition suggests promising progress for the treatment of advanced hepatocellular carcinoma (HCC). However, the underlying cellular mechanisms remain unclear because liver cancer cells apparently do not upregulate inhibitory checkpoint molecules. Here, we analysed whether regulatory T cells (Tregs) can alternatively trigger checkpoint inhibition pathways in HCC. Using flow cytometry we analysed expression of checkpoint molecules (PD-1, PD-L1, CTLA-4, GITR, Tim-3) on peripheral CD4+CD25+Foxp3+ Tregs and their secretion of inhibitory mediators (IL-10, IL-35, TGF-beta, galectin-9) in 116 individuals (50 patients with HCC, 41 non-tumour bearing liver disease controls, 25 healthy controls). Functional activity of Tregs on T effector cells (IFN-gamma production, cytotoxicity) was characterized in vitro using a lectin-dependent cellular cytotoxicity (LDCC) assay against checkpoint inhibitor-negative P815 target cells. Unlike liver patients without malignancy and healthy controls, the frequency of checkpoint inhibitor-positive Tregs inversely correlated to age of patients with HCC (PD-L1, p = 0.0080; CTLA-4, p = 0.0029) and corresponded to enhanced numbers of Tregs producing IL-10 and IL-35 (p < 0.05 each). Tregs inhibited IFN-gamma secretion and cytotoxicity of CD8+ T cells when added to LDCC against P815 cells. Treg-induced inhibition of IFN-gamma secretion could be partially blocked by neutralizing PD-1 and PD-L1 antibodies specifically in HCC patients. In HCC peripheral Tregs upregulate checkpoint inhibitors and contribute to systemic immune dysfunction and antitumoural activity by several inhibitory pathways, presumably facilitating tumour development at young age. Blocking PD-L1/PD-1 interactions in vitro selectively interfered with inhibitory Treg -T effector cell interactions in the patients with HCC and resulted in improved antitumoural activity also against checkpoint inhibitor-negative tumour cells.
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google, scholar, pubmed, cas, hepatocellular, carcinoma, cells, cancer, cell, checkpoint, regulatory, patients, article, immune, hepatol, central, hcc, pdl, immunotherapy, langhans, liver, clin, immunol, tregs, bonn, inhibition, rev, res, data, research, spengler, access, blockade, privacy, cookies, content, nischalke, krämer, expression, activity, cytotoxicity, tumour, tumor, nat, sci, information, publish, search, role, bettina,

Topics {✒️}

anna maria eis-hübinger peripheral cd4+cd25+foxp3+ tregs blocking pd-l1/pd-1 interactions month download article/chapter lectin-dependent cellular cytotoxicity branched-chain amino acids impaired t-cell functionality myeloid-derived suppressor cells pd-l1 expression serve ifn-gamma production pd-l1 antibodies specifically turning tumor-infiltrating tregs tim-3-galectin-9 pathway involves gonzalez-carmona cd4 + cd25 + regulatory article cancer immunology immune checkpoint blockade eva-maria schumacher ifn-gamma secretion partner site cologne-bonn pd-l1 blockade immune checkpoint inhibition pd-l1/l2 abstract number thu-492 german research foundation cell degranulation access privacy choices/manage cookies blood sample collection t-cell apoptosis tregs producing il-10 related subjects pd-1 immunoinhibitory receptor pd-l1 + mdscs tumour lymphocytic infiltrate combination checkpoint modulators full article pdf effector cell interactions cell line authentication systemic immune dysfunction host immune system murine p815 cells human immune system advanced hepatocellular carcinoma facilitating tumour development impaired immune function ethics declarations conflict german center regulatory cell subsets tumor-infiltrating cd8+ zhejiang univ sci

Schema {🗺️}

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      description:Immune checkpoint inhibition suggests promising progress for the treatment of advanced hepatocellular carcinoma (HCC). However, the underlying cellular mechanisms remain unclear because liver cancer cells apparently do not upregulate inhibitory checkpoint molecules. Here, we analysed whether regulatory T cells (Tregs) can alternatively trigger checkpoint inhibition pathways in HCC. Using flow cytometry we analysed expression of checkpoint molecules (PD-1, PD-L1, CTLA-4, GITR, Tim-3) on peripheral CD4+CD25+Foxp3+ Tregs and their secretion of inhibitory mediators (IL-10, IL-35, TGF-beta, galectin-9) in 116 individuals (50 patients with HCC, 41 non-tumour bearing liver disease controls, 25 healthy controls). Functional activity of Tregs on T effector cells (IFN-gamma production, cytotoxicity) was characterized in vitro using a lectin-dependent cellular cytotoxicity (LDCC) assay against checkpoint inhibitor-negative P815 target cells. Unlike liver patients without malignancy and healthy controls, the frequency of checkpoint inhibitor-positive Tregs inversely correlated to age of patients with HCC (PD-L1, p = 0.0080; CTLA-4, p = 0.0029) and corresponded to enhanced numbers of Tregs producing IL-10 and IL-35 (p < 0.05 each). Tregs inhibited IFN-gamma secretion and cytotoxicity of CD8+ T cells when added to LDCC against P815 cells. Treg-induced inhibition of IFN-gamma secretion could be partially blocked by neutralizing PD-1 and PD-L1 antibodies specifically in HCC patients. In HCC peripheral Tregs upregulate checkpoint inhibitors and contribute to systemic immune dysfunction and antitumoural activity by several inhibitory pathways, presumably facilitating tumour development at young age. Blocking PD-L1/PD-1 interactions in vitro selectively interfered with inhibitory Treg -T effector cell interactions in the patients with HCC and resulted in improved antitumoural activity also against checkpoint inhibitor-negative tumour cells.
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            name:German Center for Infection Research (DZIF), Partner Site Cologne-Bonn
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      name:German Center for Infection Research (DZIF), Partner Site Cologne-Bonn, Bonn, Germany
      name:Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany
      name:Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany
      name:Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany
      name:German Center for Infection Research (DZIF), Partner Site Cologne-Bonn, Bonn, Germany
      name:Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany
      name:German Center for Infection Research (DZIF), Partner Site Cologne-Bonn, Bonn, Germany
      name:Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany
      name:Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany
      name:Department of Experimental Pathology, University Hospital of Bonn (UKB), Bonn, Germany
      name:Institute of Virology, University Hospital of Bonn (UKB), Bonn, Germany
      name:Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany
      name:Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany
      name:Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany
      name:Department I of Internal Medicine, University Hospital of Bonn (UKB), Bonn, Germany
      name:German Center for Infection Research (DZIF), Partner Site Cologne-Bonn, Bonn, Germany
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