We are analyzing https://link.springer.com/article/10.1007/s00262-017-1972-4.

Title:
FOXO3, estrogen receptor alpha, and androgen receptor impact tumor growth rate and infiltration of dendritic cell subsets differentially between male and female mice | Cancer Immunology, Immunotherapy
Description:
Tumors evade immune recognition and destruction in many ways including the creation of an immune-suppressive tumor microenvironment (TME). Dendritic cells (DC) that infiltrate the TME are tolerogenic, and suppress effector T cells and anti-tumor activity. Previous reports demonstrated that a key regulator of tolerance in DC is the transcription factor FOXO3. Gender disparity has been studied in cancer in relation to incidence, aggressiveness, and prognosis. Few studies have touched on the importance in relation to impact on the immune system. In the current study, we show that there are significant differences in tumor growth between males and females. Additionally, frequencies and the function of FOXO3 expressed by DC subsets that infiltrate tumors vary between genders. Our results show for the first time that DC FOXO3 expression and function is altered in females. In vitro results indicate that these differences may be the result of exposure to estrogen. These differences may be critical considerations for the enhancement of immunotherapy for cancer.
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Keywords {🔍}

pubmed, article, google, scholar, cas, cells, cancer, receptor, central, dendritic, estrogen, androgen, cell, tumor, differences, immunol, function, immune, content, research, foxo, mice, expression, chen, lai, privacy, cookies, immunotherapy, alpha, access, chang, publish, search, thompson, larson, watkins, microenvironment, gender, system, responses, sex, chuang, authors, data, information, log, journal, immunology, impact, growth,

Topics {✒️}

b7-h1-dependent sex-related differences month download article/chapter article cancer immunology sexual dimorphism sex steroid-producing enzymes enhance anti-tumor immunity immune-suppressive tumor microenvironment myeloid-derived suppressor cell tolerogenic dendritic cells transcription factor foxo3 acute wound healing chronic autoimmune/inflammatory diseases androgen receptor expression sex-based differences human breast cancer th1/th2 cytokine production estrogen receptor alpha full article pdf dendritic cells aromatase expression increases androgen receptor influences privacy choices/manage cookies bone marrow precursors estrogen preferentially promotes dc foxo3 expression straub rh anti-tumor activity stroma-mediated expression loyola university chicago sex-specific control article thompson dendritic cell endometrial carcinoma microenvironment related subjects infectious diseases-common lipogenic liver tumors th2-mediated inflammations adaptive immune systems normal immune system national cancer institute cell immune responses myeloid cells european economic area previous reports demonstrated infiltrate tumors vary body defense system lai jj impaired host defense de kluyver rl double-edged sword

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