We are analyzing https://link.springer.com/article/10.1007/s00262-014-1607-y.

Title:
Successful treatment with Ipilimumab and Interleukin-2 in two patients with metastatic melanoma and systemic autoimmune disease | Cancer Immunology, Immunotherapy
Description:
Two patients were treated with immunotherapy for metastatic malignant melanoma (MM) despite suffering from systemic autoimmune disease, i.e., ulcerative colitis (UC) and Behcets disease (BD), respectively. Both patients benefitted from the treatment. The patient with UC achieved partial remission of all measurable parameters after treatment with Ipilimumab, while the patient with BD achieved a complete remission of MM after treatment with Interleukin-2 (IL-2) and Interferon-α (IFN-α). Moreover, no aggravation of symptoms related to the autoimmune diseases was seen during treatment, in contrast, clinical indications of improvement were observed. These two cases illustrate that the presence of autoimmune disease does not necessarily predict increased autoimmune toxicity in connection with immunotherapy. They also raise the question of whether autoimmune disease should continue to be an absolute exclusion criterion for treatment of MM with immunotherapy. Consequently, given the poor prognosis of refractory MM, immunotherapies need to be taken into consideration even in cases of autoimmune comorbidity due to the potential long-term benefit that these therapies offer to MM patients.
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Keywords {🔍}

article, pubmed, google, scholar, cas, melanoma, cancer, treatment, patients, disease, immunotherapy, autoimmune, interleukin, ipilimumab, metastatic, herlev, central, behcets, access, clin, therapy, immunol, copenhagen, privacy, cookies, content, nat, rev, schadendorf, cells, department, hospital, university, denmark, publish, search, systemic, pedersen, andersen, peter, inge, marie, svane, ulcerative, colitis, diseases, regulatory, oncol, hauschild, data,

Topics {✒️}

type-ii-interferon-mediated signalling month download article/chapter article cancer immunology inge marie svane t-cell transfer immunotherapy anti-ctla-4 therapy potential long-term benefit functional cd4 + cd25high regulatory systemic autoimmune disease cancer immune therapy stage iv melanoma—safety interferon alpha-2a therapy full article pdf autoimmune diseases phase ii trials tumour immunotherapy cancer consensus statement metastatic malignant melanoma immune regulatory antibodies autoimmune comorbidity due privacy choices/manage cookies therapies offer van bodegraven aa distant metastatic disease article pedersen melan-a-specific interferon-gamma-producing european economic area absolute exclusion criterion hodi fs rare side effects cell-extrinsic regulator infectious diseases autoimmune toxicity autoimmune disease conditions privacy policy cancer therapy active ulcerative colitis article log de boer nk ctla4 check access sherry rm instant access cancer immunotherapy accepting optional cookies durable complete responses updated british society gastroenterology reporting guidelines regulatory cell function

Questions {❓}

Wolchok JD, Yang AS, Weber JS (2010) Immune regulatory antibodies: are they the next advance?

Schema {🗺️}

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         headline:Successful treatment with Ipilimumab and Interleukin-2 in two patients with metastatic melanoma and systemic autoimmune disease
         description: Two patients were treated with immunotherapy for metastatic malignant melanoma (MM) despite suffering from systemic autoimmune disease, i.e., ulcerative colitis (UC) and Behcets disease (BD), respectively. Both patients benefitted from the treatment. The patient with UC achieved partial remission of all measurable parameters after treatment with Ipilimumab, while the patient with BD achieved a complete remission of MM after treatment with Interleukin-2 (IL-2) and Interferon-α (IFN-α). Moreover, no aggravation of symptoms related to the autoimmune diseases was seen during treatment, in contrast, clinical indications of improvement were observed. These two cases illustrate that the presence of autoimmune disease does not necessarily predict increased autoimmune toxicity in connection with immunotherapy. They also raise the question of whether autoimmune disease should continue to be an absolute exclusion criterion for treatment of MM with immunotherapy. Consequently, given the poor prognosis of refractory MM, immunotherapies need to be taken into consideration even in cases of autoimmune comorbidity due to the potential long-term benefit that these therapies offer to MM patients.
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            Immune therapy
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            Cancer Research
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      headline:Successful treatment with Ipilimumab and Interleukin-2 in two patients with metastatic melanoma and systemic autoimmune disease
      description: Two patients were treated with immunotherapy for metastatic malignant melanoma (MM) despite suffering from systemic autoimmune disease, i.e., ulcerative colitis (UC) and Behcets disease (BD), respectively. Both patients benefitted from the treatment. The patient with UC achieved partial remission of all measurable parameters after treatment with Ipilimumab, while the patient with BD achieved a complete remission of MM after treatment with Interleukin-2 (IL-2) and Interferon-α (IFN-α). Moreover, no aggravation of symptoms related to the autoimmune diseases was seen during treatment, in contrast, clinical indications of improvement were observed. These two cases illustrate that the presence of autoimmune disease does not necessarily predict increased autoimmune toxicity in connection with immunotherapy. They also raise the question of whether autoimmune disease should continue to be an absolute exclusion criterion for treatment of MM with immunotherapy. Consequently, given the poor prognosis of refractory MM, immunotherapies need to be taken into consideration even in cases of autoimmune comorbidity due to the potential long-term benefit that these therapies offer to MM patients.
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         Immune therapy
         Systemic autoimmune disease
         Ipilimumab
         Interleukin-2
         Oncology
         Immunology
         Cancer Research
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