We are analyzing https://link.springer.com/article/10.1007/s00262-013-1506-7.

Title:
Type I interferons induced by radiation therapy mediate recruitment and effector function of CD8+ T cells | Cancer Immunology, Immunotherapy
Description:
The need for an intact immune system for cancer radiation therapy to be effective suggests that radiation not only acts directly on the tumor but also indirectly, through the activation of host immune components. Recent studies demonstrated that endogenous type I interferons (type I IFNs) play a role in radiation-mediated anti-tumor immunity by enhancing the ability of dendritic cells to cross-prime CD8+ T cells. However, it is still unclear to what extent endogenous type I IFNs contribute to the recruitment and function of CD8+ T cells. Little is also known about the effects of type I IFNs on myeloid cells. In the current study, we demonstrate that type I and type II IFNs (IFN-γ) are both required for the increased production of CXCL10 (IP-10) chemokine by myeloid cells within the tumor after radiation treatment. Radiation-induced intratumoral IP-10 levels in turn correlate with tumor-infiltrating CD8+ T cell numbers. Moreover, type I IFNs promote potent tumor-reactive CD8+ T cells by directly affecting the phenotype, effector molecule production, and enhancing cytolytic activity. Using a unique inducible expression system to increase local levels of IFN-α exogenously, we show here that the capacity of radiation therapy to result in tumor control can be enhanced. Our preclinical approach to study the effects of local increase in IFN-α levels can be used to further optimize the combination therapy strategy in terms of dosing and scheduling, which may lead to better clinical outcome.
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Topics {✒️}

radiation-mediated anti-tumor immunity month download article/chapter radiation-induced ifn-gamma production distinct ifn-gamma-dependent mechanisms hypoxia-inducible factor-1alpha long-term tumour dormancy dimerizer-regulated gene expression ifn-resistant melanoma cells small-cell lung cancer favoring t-cell infiltration inducing ifnγ-mediated cxcl10 cd4+cd25+foxp3+ regulatory interferon-alpha/beta revisited article cancer immunology decreased tumour growth ifn-alpha induces transcription cd8{alpha} + dendritic cells full article pdf related subjects tumor-immune microenvironment human endothelial cells privacy choices/manage cookies cancer radiation therapy ifn-gamma mediates ifn-gamma priming tumor-infiltrating cd8+ ifn-α levels local radiation therapy ifn-α exogenously interferon-dependent innate effector molecule production b16 melanoma combination therapy strategy cross-prime cd8+ murine colon tumor intact immune system stereotactic body radiotherapy cells access european economic area recent studies demonstrated radiotherapy enhances cxcr3highcd8+ metastatic spinal lesions fontaine-brouty-boye regulating sting trafficking thoughtful discussions pertinent increase local levels lung cancer 56 conditions privacy policy sorensen ew tumor microenvironment

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