We are analyzing https://link.springer.com/article/10.1007/s00262-008-0516-3.

Title:
Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment | Cancer Immunology, Immunotherapy
Description:
Inflammatory cells can both suppress and stimulate tumor growth, and the influence of inflammatory cells on clinical outcome has been the focus of many studies. The purpose of this study was to evaluate the effectiveness of the neutrophil to lymphocyte ratio (NLR), a measure of the systemic inflammatory response, as an additional discriminative biomarker in epithelial ovarian cancer and to determine whether it predicts survival and recurrence. We studied 192 patients with epithelial ovarian cancer, 173 with benign ovarian tumors, 229 with benign gynecologic disease, and 405 healthy controls. Serum CA125 levels and leukocyte counts according to subtypes were recorded prior to treatment in all study subjects. In epithelial ovarian cancer, the diagnostic usefulness of NLR, in combination with CA125, was evaluated. The correlation between NLR and overall and disease-free survival was analyzed using both univariate and multivariate analyses adjusting for the known prognostic factors (age, stage, cell type, and grade). Preoperative NLR in ovarian cancer subjects (mean 6.02) was significantly higher than that in benign ovarian tumor subjects (mean 2.57), benign gynecologic disease subjects (mean 2.55), and healthy controls (mean 1.98) (P < 0.001). The sensitivity and specificity of NLR in detecting ovarian cancer was 66.1% (95% CI, 59.52–72.68%) and 82.7% (95% CI, 79.02–86.38%), respectively (cutoff value: 2.60). In early stage ovarian cancer, CA125 was not elevated in 19 out of 49 patients. Seven (36.8%) of these 19 patients were NLR positive. On Cox multivariate analysis, NLR positive, stage III/IV, and older age were independent poor prognostic factors, and being NLR positive was the most powerful predictive variable (Hazard Ratio = 8.42 [95% CI: 1.09–64.84], P = 0.041). Our findings provide evidence for the association between NLR and epithelial ovarian cancer. Preoperative NLR, in combination with CA125, may represent a simple and cost-effective method of identifying ovarian cancers, and an elevated NLR may predict an adverse outcome in ovarian cancer.
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Keywords {🔍}

cancer, article, google, scholar, pubmed, cas, ovarian, kim, nlr, ratio, lymphocyte, epithelial, survival, markers, inflammation, research, inflammatory, patients, prognostic, neutrophil, tumor, benign, subjects, van, privacy, cookies, content, hoon, serum, cell, access, res, publish, search, immunotherapy, elevated, cells, study, levels, factors, stage, preoperative, tumour, factor, nature, korea, analysis, data, information, log,

Topics {✒️}

lipid peroxidation-derived dna-lesions month download article/chapter cmb-yuhan research grant bast rc jr serum c-reactive protein article cancer immunology sung hoon kim nitric oxide-dependent mechanism jae hoon kim full article pdf privacy choices/manage cookies prognostic factor hye won hur conejo-garcia jr tumour growth ovarian cancer subjects inhibit dna repair tissue histamine levels benign gynecologic disease related subjects sang wun kim epithelial ovarian cancer benign ovarian tumors detecting ovarian cancer pro-inflammatory activity van marck ea preoperative serum cea article cho leukocyte counts identifying ovarian cancers stimulate tumor growth systemic inflammatory response european economic area multivariate analyses adjusting findings provide evidence cost-effective method pollard jw interleukin-2-based immunotherapy bone marrow eosinophilia form important compartments yonsei university college metastatic breast cancer pre-treatment neutrophil van laere sj prognostic factors lymphocyte counts–rapid conditions privacy policy tumour recurrence stage iii/iv serum ca125 levels

Questions {❓}

Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow?

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         headline:Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment
         description:Inflammatory cells can both suppress and stimulate tumor growth, and the influence of inflammatory cells on clinical outcome has been the focus of many studies. The purpose of this study was to evaluate the effectiveness of the neutrophil to lymphocyte ratio (NLR), a measure of the systemic inflammatory response, as an additional discriminative biomarker in epithelial ovarian cancer and to determine whether it predicts survival and recurrence. We studied 192 patients with epithelial ovarian cancer, 173 with benign ovarian tumors, 229 with benign gynecologic disease, and 405 healthy controls. Serum CA125 levels and leukocyte counts according to subtypes were recorded prior to treatment in all study subjects. In epithelial ovarian cancer, the diagnostic usefulness of NLR, in combination with CA125, was evaluated. The correlation between NLR and overall and disease-free survival was analyzed using both univariate and multivariate analyses adjusting for the known prognostic factors (age, stage, cell type, and grade). Preoperative NLR in ovarian cancer subjects (mean 6.02) was significantly higher than that in benign ovarian tumor subjects (mean 2.57), benign gynecologic disease subjects (mean 2.55), and healthy controls (mean 1.98) (P < 0.001). The sensitivity and specificity of NLR in detecting ovarian cancer was 66.1% (95% CI, 59.52–72.68%) and 82.7% (95% CI, 79.02–86.38%), respectively (cutoff value: 2.60). In early stage ovarian cancer, CA125 was not elevated in 19 out of 49 patients. Seven (36.8%) of these 19 patients were NLR positive. On Cox multivariate analysis, NLR positive, stage III/IV, and older age were independent poor prognostic factors, and being NLR positive was the most powerful predictive variable (Hazard Ratio = 8.42 [95% CI: 1.09–64.84], P = 0.041). Our findings provide evidence for the association between NLR and epithelial ovarian cancer. Preoperative NLR, in combination with CA125, may represent a simple and cost-effective method of identifying ovarian cancers, and an elevated NLR may predict an adverse outcome in ovarian cancer.
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            Leukocyte differential count
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            Diagnostic marker
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      headline:Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment
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