We are analyzing https://link.springer.com/article/10.1007/s00262-008-0459-8.

Title:
Toll-like receptors expressed in tumor cells: targets for therapy | Cancer Immunology, Immunotherapy
Description:
Toll-like receptors (TLRs), mainly expressing in human immune related cells and epithelial cells, play an essential role in the host defense against microbes by recognizing conserved bacterial molecules. Recently, the expression or up-regulation of TLRs has been detected in many tumor cell lines or tumors, especially epithelial derived cancers. Although the TLR profile varies on different tumor cells, the current evidences indicate that the expression of TLRs is functionally associated with tumor progression. TLR expression may promote malignant transformation of epithelial cells. Engagement of TLRs increases tumor growth and tumor immune escape, and induces apoptosis resistance and chemoresistance in some tumor cells. These findings demonstrate that TLR is a promising target for the development of anticancer drugs and make TLR agonists or antagonists the potential agents for tumor therapy.
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Keywords {🔍}

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Topics {✒️}

month download article/chapter tlr-mediated cytokine/chemokine production deoxycytidyl-phosphate-deoxyguanosine dc poorly-differentiated gastric adenocarcinomas dendritic cell-based immunotherapy single-stranded rna viruses cell wall skeleton article cancer immunology ifn-beta promoter full article pdf hepatocyte growth factor privacy choices/manage cookies tumor immune escape guangdong key laboratory human dendritic cells article yu tumor cell lines female reproductive tract bacterial cpg oligodeoxynucleotides human cancer cells single-stranded rna melanoma cell lines dependent signaling pathways promote malignant transformation lps gene product myd88-independent toll innate immune response toll/il-1 receptor domain double-stranded rna chronic lymphocytic leukemia microbial dna induces induces apoptosis resistance inducing immunosuppressive cytokines defective lps signaling epithelial derived cancers receptor 4-mediated signaling prostate cancer risk receptor signaling pathway mediating immune response european economic area therapy review published zhou xx species-specific recognition el-omar em janeway ca jr leucine-rich repeat human intestinal epithelium muller-hermelink hk 174del polymorphism influences ileal pouch mucosa

Questions {❓}

Salaun B, Lebecque S, Matikainen S, Rimoldi D, Romero P (2007) Toll-like receptor 3 expressed by melanoma cells as a target for therapy?

Schema {🗺️}

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