We are analyzing https://link.springer.com/article/10.1007/s00262-007-0286-3.

Title:
Density of DC-LAMP+ mature dendritic cells in combination with activated T lymphocytes infiltrating primary cutaneous melanoma is a strong independent prognostic factor | Cancer Immunology, Immunotherapy
Description:
As the most potent antigen presenting cells, dendritic cells (DCs) play key roles in the immune response against tumors. Their density in the tumor tissue has been associated with prognosis in patients with various cancers. However, few studies have been aimed at the presence and maturation state of DCs in cutaneous melanoma, with regard to their potential clinical correlates. In this study, the density of DCs expressing CD1a and the maturation marker DC-LAMP was determined by immunohistochemistry in primary tumor samples from 82 patients with cutaneous malignant melanoma. Intratumoral and peritumoral cell densities were analyzed in relation to tumor thickness and the subsequent development of metastases, as well as to patients’ survival. CD1a+ DCs were found both infiltrating melanoma cell nests and in the surrounding stroma, while DC-LAMP+ mature DCs were generally confined to the peritumoral areas, associated with lymphocytic infiltrates. DC density values significantly correlated with the number of activated (CD25+ or OX40+) T lymphocytes (p < 0.001). The degree of infiltration by CD1a+ and DC-LAMP+ DCs showed strong inverse correlation with the thickness of melanomas (p < 0.001). High peritumoral density of mature DCs was associated with significantly longer survival (p = 0.0195), while density of CD1a+ cells had a prognostic impact of borderline significance (p = 0.0610). Moreover, combination of high peritumoral CD1a+ or DC-LAMP+ cell density with high number of CD25+ or OX40+ lymphocytes identified patient subgroups with more favorable survival compared to other subgroups. A multivariate survival analysis involving DC and activated T-cell densities alone and in combinations, as well as traditional prognostic factors, identified high DC-LAMP+ cell/high OX40+ cell density and Breslow index as independent predictors of good prognosis. These results suggest that the presence of CD1a+ DCs primarily depends on the thickness of melanomas, without direct relationship with the patients’ survival. On the other hand, the density of mature DCs, especially in association with that of activated T cells, proved of prognostic importance, suggesting that these parameters could be considered as signs of a functional immune response associated with better outcome of the disease.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

cells, dendritic, google, scholar, pubmed, article, cas, cancer, cell, melanoma, human, immunol, density, mature, factor, dclamp, prognostic, dcs, tumor, clin, cutaneous, carcinoma, res, activated, patients, maturation, invest, lymphocytes, prognosis, cda, survival, access, expression, institute, privacy, cookies, content, primary, ladányi, antigen, immune, peritumoral, immunity, immature, oncology, national, budapest, hungary, publish, search,

Topics {✒️}

month download article/chapter dc-lamp+ cell density dendritic cells/langerhans cells maturation marker dc-lamp dc-lamp+ mature dcs activated t-cell densities melanoma-antigen-specific anergy inflammatory cell infiltrates human breast carcinomas dermal dendritic cells article cancer immunology hla-dr expression full article pdf mature dendritic cells hepatocyte growth factor related subjects breast carcinoma tissue cutaneous langerhans cells cell immunohistochemistry access dendritic cell origins t-cell activation renal cell carcinoma tumor-infiltrating lymphocytes gabrilovich di dendritic cell infiltration recruiting dendritic cells myeloid dendritic cells privacy choices/manage cookies intratumoral dendritic cells immature dendritic cells de gruijl td dendritic cell maturation tolerogenic dendritic cells human tumors inhibits high peritumoral density skin dendritic cells peritumoral cell densities high peritumoral cd1a+ antitumor immune responses stimulates tumor cells lyse tumor cells article ladányi dcs expressing cd1a significantly longer survival defective antigen presentation dc-lamp primary cutaneous melanomas ζ-chain expression primary tumor samples triggering antigen spreading

Questions {❓}

Lutz M, Schuler G (2002) Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Density of DC-LAMP+ mature dendritic cells in combination with activated T lymphocytes infiltrating primary cutaneous melanoma is a strong independent prognostic factor
         description:As the most potent antigen presenting cells, dendritic cells (DCs) play key roles in the immune response against tumors. Their density in the tumor tissue has been associated with prognosis in patients with various cancers. However, few studies have been aimed at the presence and maturation state of DCs in cutaneous melanoma, with regard to their potential clinical correlates. In this study, the density of DCs expressing CD1a and the maturation marker DC-LAMP was determined by immunohistochemistry in primary tumor samples from 82 patients with cutaneous malignant melanoma. Intratumoral and peritumoral cell densities were analyzed in relation to tumor thickness and the subsequent development of metastases, as well as to patients’ survival. CD1a+ DCs were found both infiltrating melanoma cell nests and in the surrounding stroma, while DC-LAMP+ mature DCs were generally confined to the peritumoral areas, associated with lymphocytic infiltrates. DC density values significantly correlated with the number of activated (CD25+ or OX40+) T lymphocytes (p < 0.001). The degree of infiltration by CD1a+ and DC-LAMP+ DCs showed strong inverse correlation with the thickness of melanomas (p < 0.001). High peritumoral density of mature DCs was associated with significantly longer survival (p = 0.0195), while density of CD1a+ cells had a prognostic impact of borderline significance (p = 0.0610). Moreover, combination of high peritumoral CD1a+ or DC-LAMP+ cell density with high number of CD25+ or OX40+ lymphocytes identified patient subgroups with more favorable survival compared to other subgroups. A multivariate survival analysis involving DC and activated T-cell densities alone and in combinations, as well as traditional prognostic factors, identified high DC-LAMP+ cell/high OX40+ cell density and Breslow index as independent predictors of good prognosis. These results suggest that the presence of CD1a+ DCs primarily depends on the thickness of melanomas, without direct relationship with the patients’ survival. On the other hand, the density of mature DCs, especially in association with that of activated T cells, proved of prognostic importance, suggesting that these parameters could be considered as signs of a functional immune response associated with better outcome of the disease.
         datePublished:2007-02-06T00:00:00Z
         dateModified:2007-02-06T00:00:00Z
         pageStart:1459
         pageEnd:1469
         sameAs:https://doi.org/10.1007/s00262-007-0286-3
         keywords:
            Melanoma
            Metastasis
            Dendritic cell
            Activated T cell
            Immunohistochemistry
            Oncology
            Immunology
            Cancer Research
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-007-0286-3/MediaObjects/262_2007_286_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-007-0286-3/MediaObjects/262_2007_286_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-007-0286-3/MediaObjects/262_2007_286_Fig3_HTML.gif
         isPartOf:
            name:Cancer Immunology, Immunotherapy
            issn:
               1432-0851
               0340-7004
            volumeNumber:56
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Andrea Ladányi
               affiliation:
                     name:National Institute of Oncology
                     address:
                        name:Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Judit Kiss
               affiliation:
                     name:National Institute of Oncology
                     address:
                        name:Department of Dermatology, National Institute of Oncology, Budapest, Hungary
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Beáta Somlai
               affiliation:
                     name:Semmelweis University
                     address:
                        name:Institute of Dermato-Venerology, Semmelweis University, Budapest, Hungary
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Katalin Gilde
               affiliation:
                     name:National Institute of Oncology
                     address:
                        name:Department of Dermatology, National Institute of Oncology, Budapest, Hungary
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zsuzsanna Fejős
               affiliation:
                     name:National Institute of Oncology
                     address:
                        name:Department of Dermatology, National Institute of Oncology, Budapest, Hungary
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anita Mohos
               affiliation:
                     name:1st Institute of Pathology, Semmelweis University
                     address:
                        name:1st Institute of Pathology, Semmelweis University, Budapest, Hungary
                        type:PostalAddress
                     type:Organization
               type:Person
               name:István Gaudi
               affiliation:
                     name:National Institute of Oncology
                     address:
                        name:National Cancer Registry, National Institute of Oncology, Budapest, Hungary
                        type:PostalAddress
                     type:Organization
               type:Person
               name:József Tímár
               affiliation:
                     name:National Institute of Oncology
                     address:
                        name:Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Density of DC-LAMP+ mature dendritic cells in combination with activated T lymphocytes infiltrating primary cutaneous melanoma is a strong independent prognostic factor
      description:As the most potent antigen presenting cells, dendritic cells (DCs) play key roles in the immune response against tumors. Their density in the tumor tissue has been associated with prognosis in patients with various cancers. However, few studies have been aimed at the presence and maturation state of DCs in cutaneous melanoma, with regard to their potential clinical correlates. In this study, the density of DCs expressing CD1a and the maturation marker DC-LAMP was determined by immunohistochemistry in primary tumor samples from 82 patients with cutaneous malignant melanoma. Intratumoral and peritumoral cell densities were analyzed in relation to tumor thickness and the subsequent development of metastases, as well as to patients’ survival. CD1a+ DCs were found both infiltrating melanoma cell nests and in the surrounding stroma, while DC-LAMP+ mature DCs were generally confined to the peritumoral areas, associated with lymphocytic infiltrates. DC density values significantly correlated with the number of activated (CD25+ or OX40+) T lymphocytes (p < 0.001). The degree of infiltration by CD1a+ and DC-LAMP+ DCs showed strong inverse correlation with the thickness of melanomas (p < 0.001). High peritumoral density of mature DCs was associated with significantly longer survival (p = 0.0195), while density of CD1a+ cells had a prognostic impact of borderline significance (p = 0.0610). Moreover, combination of high peritumoral CD1a+ or DC-LAMP+ cell density with high number of CD25+ or OX40+ lymphocytes identified patient subgroups with more favorable survival compared to other subgroups. A multivariate survival analysis involving DC and activated T-cell densities alone and in combinations, as well as traditional prognostic factors, identified high DC-LAMP+ cell/high OX40+ cell density and Breslow index as independent predictors of good prognosis. These results suggest that the presence of CD1a+ DCs primarily depends on the thickness of melanomas, without direct relationship with the patients’ survival. On the other hand, the density of mature DCs, especially in association with that of activated T cells, proved of prognostic importance, suggesting that these parameters could be considered as signs of a functional immune response associated with better outcome of the disease.
      datePublished:2007-02-06T00:00:00Z
      dateModified:2007-02-06T00:00:00Z
      pageStart:1459
      pageEnd:1469
      sameAs:https://doi.org/10.1007/s00262-007-0286-3
      keywords:
         Melanoma
         Metastasis
         Dendritic cell
         Activated T cell
         Immunohistochemistry
         Oncology
         Immunology
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-007-0286-3/MediaObjects/262_2007_286_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-007-0286-3/MediaObjects/262_2007_286_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00262-007-0286-3/MediaObjects/262_2007_286_Fig3_HTML.gif
      isPartOf:
         name:Cancer Immunology, Immunotherapy
         issn:
            1432-0851
            0340-7004
         volumeNumber:56
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Andrea Ladányi
            affiliation:
                  name:National Institute of Oncology
                  address:
                     name:Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Judit Kiss
            affiliation:
                  name:National Institute of Oncology
                  address:
                     name:Department of Dermatology, National Institute of Oncology, Budapest, Hungary
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Beáta Somlai
            affiliation:
                  name:Semmelweis University
                  address:
                     name:Institute of Dermato-Venerology, Semmelweis University, Budapest, Hungary
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Katalin Gilde
            affiliation:
                  name:National Institute of Oncology
                  address:
                     name:Department of Dermatology, National Institute of Oncology, Budapest, Hungary
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zsuzsanna Fejős
            affiliation:
                  name:National Institute of Oncology
                  address:
                     name:Department of Dermatology, National Institute of Oncology, Budapest, Hungary
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anita Mohos
            affiliation:
                  name:1st Institute of Pathology, Semmelweis University
                  address:
                     name:1st Institute of Pathology, Semmelweis University, Budapest, Hungary
                     type:PostalAddress
                  type:Organization
            type:Person
            name:István Gaudi
            affiliation:
                  name:National Institute of Oncology
                  address:
                     name:National Cancer Registry, National Institute of Oncology, Budapest, Hungary
                     type:PostalAddress
                  type:Organization
            type:Person
            name:József Tímár
            affiliation:
                  name:National Institute of Oncology
                  address:
                     name:Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cancer Immunology, Immunotherapy
      issn:
         1432-0851
         0340-7004
      volumeNumber:56
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:National Institute of Oncology
      address:
         name:Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
         type:PostalAddress
      name:National Institute of Oncology
      address:
         name:Department of Dermatology, National Institute of Oncology, Budapest, Hungary
         type:PostalAddress
      name:Semmelweis University
      address:
         name:Institute of Dermato-Venerology, Semmelweis University, Budapest, Hungary
         type:PostalAddress
      name:National Institute of Oncology
      address:
         name:Department of Dermatology, National Institute of Oncology, Budapest, Hungary
         type:PostalAddress
      name:National Institute of Oncology
      address:
         name:Department of Dermatology, National Institute of Oncology, Budapest, Hungary
         type:PostalAddress
      name:1st Institute of Pathology, Semmelweis University
      address:
         name:1st Institute of Pathology, Semmelweis University, Budapest, Hungary
         type:PostalAddress
      name:National Institute of Oncology
      address:
         name:National Cancer Registry, National Institute of Oncology, Budapest, Hungary
         type:PostalAddress
      name:National Institute of Oncology
      address:
         name:Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Andrea Ladányi
      affiliation:
            name:National Institute of Oncology
            address:
               name:Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Judit Kiss
      affiliation:
            name:National Institute of Oncology
            address:
               name:Department of Dermatology, National Institute of Oncology, Budapest, Hungary
               type:PostalAddress
            type:Organization
      name:Beáta Somlai
      affiliation:
            name:Semmelweis University
            address:
               name:Institute of Dermato-Venerology, Semmelweis University, Budapest, Hungary
               type:PostalAddress
            type:Organization
      name:Katalin Gilde
      affiliation:
            name:National Institute of Oncology
            address:
               name:Department of Dermatology, National Institute of Oncology, Budapest, Hungary
               type:PostalAddress
            type:Organization
      name:Zsuzsanna Fejős
      affiliation:
            name:National Institute of Oncology
            address:
               name:Department of Dermatology, National Institute of Oncology, Budapest, Hungary
               type:PostalAddress
            type:Organization
      name:Anita Mohos
      affiliation:
            name:1st Institute of Pathology, Semmelweis University
            address:
               name:1st Institute of Pathology, Semmelweis University, Budapest, Hungary
               type:PostalAddress
            type:Organization
      name:István Gaudi
      affiliation:
            name:National Institute of Oncology
            address:
               name:National Cancer Registry, National Institute of Oncology, Budapest, Hungary
               type:PostalAddress
            type:Organization
      name:József Tímár
      affiliation:
            name:National Institute of Oncology
            address:
               name:Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
      name:Department of Dermatology, National Institute of Oncology, Budapest, Hungary
      name:Institute of Dermato-Venerology, Semmelweis University, Budapest, Hungary
      name:Department of Dermatology, National Institute of Oncology, Budapest, Hungary
      name:Department of Dermatology, National Institute of Oncology, Budapest, Hungary
      name:1st Institute of Pathology, Semmelweis University, Budapest, Hungary
      name:National Cancer Registry, National Institute of Oncology, Budapest, Hungary
      name:Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(160)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.1s.

LINK . SPRINGER . COM {}