We are analyzing https://link.springer.com/article/10.1007/s00262-004-0540-x.

Title:
Escape from immunotherapy: possible mechanisms that influence tumor regression/progression | Cancer Immunology, Immunotherapy
Description:
Tumor escape is one major obstacle that has to be addressed prior to designing and delivering successful immunotherapy. There is compelling evidence to support the notion that immunogenic tumors, in murine models and cancer patients, can be rejected by the immune system under optimum conditions for activating adaptive and nonadaptive antitumor immune responses. Despite this capability, a large number of tumors continue to grow and evade recognition and/or destruction by the immune system. The limited success in current immunotherapeutic strategies may be due to a variety of reasons: failure of effector cells to compete with the growing tumor burden, production of humoral factors by tumors that locally block cytotoxicity, antigen/MHC loss, T-cell dysfunction, production of suppressor T cells—to name but a few causes for therapeutic ineffectiveness for the particular malignancy being treated. To optimize immunotherapy strategies, correction of immune-activating signals, eradication of inhibitory factors, and the evasion from newly developed immunoresistant tumor phenotypes need to be simultaneously considered.
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Keywords {🔍}

google, scholar, pubmed, cas, cancer, article, tumor, cells, immunol, immunotherapy, cell, expression, patients, immune, tumors, human, melanoma, class, med, escape, res, antigen, vaccines, van, rees, cambridge, garrido, exp, ali, responses, loss, immunother, hla, antigens, immunity, clin, mechanisms, tcell, activation, nat, ligand, growth, evasion, stern, eds, university, breast, mechanism, chen, downregulation,

Topics {✒️}

formalin-fixed paraffin-embedded primary h-2kbdb double-knockout mice month download article/chapter transforming growth factor-beta antigen-specific t-cell responses signal-transducing zeta chains transforming growth factor t-cell immunotherapy revives t-cell receptor complex herpes simplex virus tumor-derived macrophages suppresses tumor-infiltrating t-cells p1a-encoded tumor antigen article cancer immunology lymphocyte-tumor cell interaction small-cell lung cancer glucocorticoid-induced tnf receptor influence tumor regression/progression cellular flice-inhibitory protein cell-mediated tumor immunity late-stage ovarian cancer antigen-specific adaptive immunity antigen-specific ctl response tumor-induced escape mechanisms subcutaneous tumor growth inhibits tumor-specific ifn-gamma-dependent suppression full article pdf fas-mediated apoptosis ctl-defined cancer vaccines article forms part host infiltrating cells tumor-derived macrophages transduce cytokine genes privacy choices/manage cookies tumor regression induced t-cell dysfunction cell activation induced dendritic cell maturation �tumor escape” phenotypes van duivenvoorde lm cd4+cd25+ suppressor lymphocytes tumor-bearing mice intracellular fas ligand dendritic cell approaches t-cell tolerance dendritic cell infilteration tnf receptor superfamily human tumor tissues gp70 tumor antigen

Questions {❓}

Abken H, Hombach A, Heuser C, Kronfeld K, Seliger B (2002) Tuning tumor-specific T-cell activation: a matter of costimulation?
Antony PA, Restifo NP (2002) Do CD4+ CD25+ immunoregulatory T cells hinder tumor immunotherapy?
Levey DL, Srivastava PK (1996) Alterations in T cells of cancer-bearers: whence specificity?
Mellor AL, Munn DH (1999) Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?

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