We are analyzing https://link.springer.com/article/10.1007/s00259-018-4171-4.

Title:
FDG PET/CT for assessing tumour response to immunotherapy | European Journal of Nuclear Medicine and Molecular Imaging
Description:
This paper follows the immunotherapy symposium held during the European Association of Nuclear Medicine (EANM) 2017 Annual Congress. The biological basis of the immune checkpoint inhibitors and the drugs most frequently used for the treatment of solid tumours are reviewed. The issues of pseudoprogression (frequency, timeline), hyperprogression and immune-related side effects are discussed, as well as their implications for patient management. A review of the recent literature on the use of FDG PET for assessment of immunotherapy is presented, and recommendations are provided for assessing tumour response and reporting immune-related side effects with FDG PET based on published data and experts’ experience. Representative clinical cases are also discussed.
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Keywords {🔍}

response, pubmed, patients, pet, article, immunotherapy, google, scholar, immune, treatment, criteria, fdg, cancer, imaging, tumour, metabolic, cas, melanoma, lesions, petct, checkpoint, progression, central, inhibitors, pseudoprogression, immunerelated, assessment, cells, uptake, med, cell, nivolumab, disease, baseline, eortc, early, scan, evaluation, nucl, httpsdoiorgs, clinical, therapy, table, ipilimumab, treated, cycles, eur, hyperprogression, patient, lung,

Topics {✒️}

positron emission tomography immune-related side effects anti-pd-1/pd-l1 therapy 18f-fdg pet/ct imaging f-fdg pet/ct imaging pd1/pd-l1 binding inhibits article download pdf immune-related adverse effects anti-pd1/pd-l1 agents fused pet/ct image christophe le tourneau immune-related adverse events 18f-fdg pet/ct f-18 fdg pet/ct f-fdg-pet/ct f-fdg pet/ct fused pet/ct images anti-pd-1/pd-l1 reduces treg-mediated immunosuppression molecularly targeted therapies conventional contrast-enhanced ct tumor-infiltrating lymphocytes confers biopsy-proven melanoma residue small-cell lung cancer improved recurrence-free survival anti-pd-l1 agent pd1/pd-l1 inhibitors immune-related response criteria recurrent squamous-cell carcinoma immune-privileged tissue microenvironment low-grade left hilar pd1/pd-l1 axis pd1/pd-l1 expression small-bowel uptake due molecularly targeted therapy anti-pd-1 therapy pd-l1-selected patients eanm/earl harmonization strategies longer progression-free survival background tissue comparisons pd-l1-negative patients peter maccallum cancer block immunological checkpoints adjacent background activity privacy choices/manage cookies full access immune therapy activity pd-l1/2 pathway immune checkpoint inhibitors molecularly targeted agents

Questions {❓}

Can an immune checkpoint inhibitor (sometimes) make things worse?
Is it time to change our vision of tumor metabolism prior to immunotherapy?

Schema {🗺️}

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         description:This paper follows the immunotherapy symposium held during the European Association of Nuclear Medicine (EANM) 2017 Annual Congress. The biological basis of the immune checkpoint inhibitors and the drugs most frequently used for the treatment of solid tumours are reviewed. The issues of pseudoprogression (frequency, timeline), hyperprogression and immune-related side effects are discussed, as well as their implications for patient management. A review of the recent literature on the use of FDG PET for assessment of immunotherapy is presented, and recommendations are provided for assessing tumour response and reporting immune-related side effects with FDG PET based on published data and experts’ experience. Representative clinical cases are also discussed.
         datePublished:2018-10-05T00:00:00Z
         dateModified:2018-10-05T00:00:00Z
         pageStart:238
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            Immune checkpoint inhibitors
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            Hyperprogression
            Immune-related side effects
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            Imaging / Radiology
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            Cardiology
            Oncology
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      headline:FDG PET/CT for assessing tumour response to immunotherapy
      description:This paper follows the immunotherapy symposium held during the European Association of Nuclear Medicine (EANM) 2017 Annual Congress. The biological basis of the immune checkpoint inhibitors and the drugs most frequently used for the treatment of solid tumours are reviewed. The issues of pseudoprogression (frequency, timeline), hyperprogression and immune-related side effects are discussed, as well as their implications for patient management. A review of the recent literature on the use of FDG PET for assessment of immunotherapy is presented, and recommendations are provided for assessing tumour response and reporting immune-related side effects with FDG PET based on published data and experts’ experience. Representative clinical cases are also discussed.
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      dateModified:2018-10-05T00:00:00Z
      pageStart:238
      pageEnd:250
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         Immune checkpoint inhibitors
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         Hyperprogression
         Immune-related side effects
         Therapy response
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         Imaging / Radiology
         Orthopedics
         Cardiology
         Oncology
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PostalAddress:
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      name:Normandie University, Caen, France
      name:INSERM 1086 ANTICIPE, Normandie University, Caen, France
      name:EANM Oncology Committee, Vienna, Austria
      name:Centre for Molecular Imaging, Department of Cancer Imaging, Peter MacCallum Cancer, Melbourne, Australia
      name:Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
      name:Department of Medical Oncology, Institut Curie, Paris & Saint-Cloud, France
      name:INSERM U900 Research Unit, Saint-Cloud, France
      name:Princess Margaret Cancer Centre, Department of Medical Oncology, University of Toronto, Toronto, Canada
      name:EANM Oncology Committee, Vienna, Austria
      name:Nuclear Medicine, Policlinico S. Orsola, Università di Bologna, Bologna, Italy
      name:EANM Oncology Committee, Vienna, Austria
      name:Nuclear Medicine Department, Humanitas Clinical and Research Hospital, Rozzano, Italy

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