We are analyzing https://link.springer.com/article/10.1007/s00259-005-1767-2.

Title:
Brain FDG PET study of normal aging in Japanese: effect of atrophy correction | European Journal of Nuclear Medicine and Molecular Imaging
Description:
Purpose The aim of this study was to investigate the effects of atrophy correction on the results of 18F-fluorodeoxyglucose positron emission tomography (FDG PET) in the context of normal aging. Methods Before the human study was performed, a Hoffman 3D brain phantom experiment was carried out in order to validate a newly developed correction method for partial volume effects (PVEs). Brain FDG PET was then performed in 139 healthy Japanese volunteers (71 men, 68 women; age 24–81 years). PET images were corrected for PVEs using grey matter volume, which was segmented from co-registered magnetic resonance images and convoluted with the spatial resolution of the PET scanner. We investigated the correlation between advancing age and relative regional FDG activity, which was normalised to the global activity before and after PVE correction using Statistical Parametric Mapping 99. Results The PET image, when corrected for PVEs, provided more homogeneous tracer distribution in the whole phantom than in the original PET image. The human PET study of both sexes revealed significant negative correlations between age and relative FDG activity in the bilateral perisylvian and medial frontal areas before PVE correction. However, these negative correlations were largely resolved after PVE correction. Conclusion Correction for PVEs was effective in our FDG PET study. The reduction in FDG uptake with advancing age that was detected by FDG PET without PVE correction could be accounted for largely by an age-related cerebral volume loss in the bilateral perisylvian and medial frontal areas.
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Keywords {🔍}

google, scholar, aging, brain, pet, normal, article, human, correction, fdg, tomography, cerebral, glucose, study, effects, positron, emission, regional, volume, disease, metabolism, age, metabolic, imaging, atrophy, healthy, alzheimers, blood, flow, function, method, access, neurol, nucl, privacy, cookies, content, journal, research, effect, matsuda, partial, volunteers, mapping, frontal, cereb, metab, med, res, medical,

Topics {✒️}

month download article/chapter statistical parametric mapping voxel-based morphometric study mri-based correction high-resolution digital pet positron emission tomography human frontal cortex—developmental partial volume averaging partial volume effects partial-volume effects molecular imaging aims magnetic resonance imaging article european journal voxel-based morphometry privacy choices/manage cookies full article pdf glucose utilization rates grey matter volume computed tomography assessments cerebral glucose metabolism quantitative synaptic alterations european economic area [18f]fluorodeoxyglucose method gray matter loss fdg-pet studies brain spet abnormalities brain fdg pet mr-based method original pet image human pet study fdg pet study margolin ra aging human cortex multicenter fdg pet human brain morphometry aging human brain relative fdg activity posterior cingulate cortex brain gray matter brain perfusion spect mini-mental state medial frontal areas frontal lobe degeneration frontal metabolism demonstrated healthy volunteers determined homogeneous tracer distribution cerebrovascular risk factors planar stereotaxic atlas exaggerated aging process test-retest reproducibility

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Changes in brain morphology in Alzheimer disease and normal aging: is Alzheimer disease an exaggerated aging process?

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